{"id":97771,"date":"2024-08-13T16:42:28","date_gmt":"2024-08-13T09:42:28","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=97771"},"modified":"2025-07-24T13:30:37","modified_gmt":"2025-07-24T06:30:37","slug":"sofuled-90mg-400mg","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/sofuled-90mg-400mg\/","title":{"rendered":"Sofuled 90mg\/400mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, <\/b>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Sofuled 90mg\/400mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty TNHH BRV Healthcare, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 QL\u0110B-710-18.<\/b><\/p>\n

Sofuled 90mg\/400mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n

Th\u00e0nh ph\u1ea7n<\/h3>\n

Vi\u00ean u\u1ed1ng Sofuled 90mg\/400mg<\/b> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n\n\n\n\n\n\n
Th\u00e0nh ph\u1ea7n<\/td>\nH\u00e0m l\u01b0\u1ee3ng<\/td>\n<\/tr>\n
Ledipasvir<\/td>\n90mg<\/td>\n<\/tr>\n
Sofosbuvir<\/td>\n400mg<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c<\/td>\nV\u1eeba \u0111\u1ee7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/p>\n

Tr\u00ecnh b\u00e0y<\/h3>\n

S\u0110K: QL\u0110B-710-18.<\/p>\n

Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd 28 vi\u00ean.<\/p>\n

Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam.<\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Sofuled 90mg\/400mg<\/h2>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n\n\n\n\n\n
Th\u00e0nh ph\u1ea7n<\/td>\nC\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/td>\n<\/tr>\n
Ledipasvir<\/td>\nC\u00f3 t\u00e1c \u0111\u1ed9ng ch\u00ednh l\u00e0 \u1ee9c ch\u1ebf protein NS5V c\u00f3 tr\u00ean virus vi\u00eam gan C. Trong khi \u0111\u00f3, Protein n\u00e0y r\u1ea5t c\u1ea7n v\u1edbi s\u1ef1 sao ch\u00e9p c\u1ee7a virus.<\/td>\n<\/tr>\n
Sofosbuvir<\/td>\n\u0110\u1ed1i v\u1edbi Sofosbuvir, ch\u1ea5t n\u00e0y \u1ee9c ch\u1ebf polymerase ARN ph\u1ee5 thu\u1ed9c v\u00e0o NS5B tr\u00ean virus. Khi v\u00e0o c\u01a1 th\u1ec3, ch\u1ea5t n\u00e0y s\u1ebd \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 uridin triphosphat, ch\u1ea5t n\u00e0y t\u00edch h\u1ee3p v\u00e0o ARN c\u1ee7a virus v\u00e0 l\u00e0m k\u1ebft th\u00fac chu\u1ed7i.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n\n\n\n\n\n
Th\u00e0nh ph\u1ea7n<\/td>\nD\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/td>\n<\/tr>\n
Ledipasvir<\/td>\nGi\u00e1 tr\u1ecb n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trung b\u00ecnh c\u1ee7a Ledipasvir \u1edf huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 4-4,5 ti\u1ebfng.<\/p>\n

Thu\u1ed1c g\u1eafn l\u00ean protein huy\u1ebft, l\u01b0\u1ee3ng g\u1eafn k\u1ebft chi\u1ebfm 99,8% li\u1ec1u.<\/p>\n

Ledipasvir c\u00f3 b\u1ecb oxy h\u00f3a, t\u1ea1o ch\u1ea5t chuy\u1ec3n h\u00f3a M19.<\/p>\n

Kho\u1ea3ng 70% d\u1ea1ng g\u1ed1c v\u00e0 2,2% ch\u1ea5t M19 th\u1ea3i qua ph\u00e2n. Th\u1eddi gian b\u00e1n h\u1ee7y c\u1ee7a Ledipasvir kho\u1ea3ng 47 ti\u1ebfng.<\/td>\n<\/tr>\n

Sofosbuvir<\/td>\nSofosbuvir c\u0169ng \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh, sau g\u1ea7n 0,8-1 ti\u1ebfng s\u1ebd cho Cmax trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n

Kho\u1ea3ng 61-65% thu\u1ed1c Sofosbuvir g\u1eafn l\u00ean protein huy\u1ebft.<\/p>\n

Sofosbuvir \u0111\u1ebfn gan s\u1ebd \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 nucleoside triphosphat mang ho\u1ea1t t\u00ednh. S\u1ef1 chuy\u1ec3n h\u00f3a c\u00f3 li\u00ean quan t\u1edbi th\u1ee7y ph\u00e2n v\u00e0 phosphoryl h\u00f3a.<\/p>\n

Thu\u1ed1c ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u, ngo\u00e0i ra c\u00f2n theo ph\u00e2n v\u00e0 kh\u00ed th\u1edf. Th\u1eddi gian b\u00e1n h\u1ee7y c\u1ee7a Sofosbuvir l\u00e0 0,5 ti\u1ebfng.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Thu\u1ed1c Sofuled 90mg\/400mg ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n

D\u00f9ng cho c\u00e1c b\u1ec7nh nh\u00e2n t\u1eeb 12 tu\u1ed5i b\u1ecb vi\u00eam gan C th\u1ec3 m\u1ea1n thu\u1ed9c genotype 1, 3, 4,5 v\u00e0 6.<\/p>\n

\"Thu\u1ed1c<\/a>
Thu\u1ed1c Sofuled 90mg\/400mg \u0111i\u1ec1u tr\u1ecb vi\u00eam gan C<\/figcaption><\/figure>\n

Li\u1ec1u d\u00f9ng thu\u1ed1c Sofuled 90mg\/400mg<\/h2>\n

U\u1ed1ng m\u1ed7i ng\u00e0y 1 vi\u00ean thu\u1ed1c v\u00e0o b\u1eefa \u0103n hay c\u00e1ch b\u1eefa \u0103n.<\/p>\n

Th\u1eddi gian d\u00f9ng thu\u1ed1c t\u00f9y thu\u1ed9c v\u00e0o t\u00ecnh tr\u1ea1ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh. Th\u01b0\u1eddng l\u00e0 12 tu\u1ea7n, tr\u1eeb tr\u01b0\u1eddng h\u1ee3p b\u1ecb nhi\u1ec5m HCV genotype 1 \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb nh\u01b0ng c\u00f3 x\u01a1 gan l\u00e0 24 tu\u1ea7n.<\/p>\n

Tr\u1ebb < 12 tu\u1ed5i: T\u00ednh an to\u00e0n c\u0169ng nh\u01b0 hi\u1ec7u qu\u1ea3 c\u1ee7a Sofuled tr\u00ean c\u00e1c b\u00e9 ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u.<\/p>\n

Ng\u01b0\u1eddi l\u1edbn tu\u1ed5i, suy gan, th\u1eadn \u0111\u1ec1u kh\u00f4ng c\u1ea7n ph\u1ea3i ch\u1ec9nh s\u1eeda li\u1ec1u u\u1ed1ng.<\/p>\n

Kh\u00f4ng s\u1eed d\u1ee5ng Sofuled 90mg\/400mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n

B\u1ecb d\u1ecb \u1ee9ng Sofosbuvir, Ledipasvir ho\u1eb7c t\u00e1 d\u01b0\u1ee3c c\u1ee7a Sofuled.<\/p>\n

Kh\u00f4ng n\u00ean k\u1ebft h\u1ee3p c\u00f9ng Rosuvastatin hay c\u00e1c thu\u1ed1c c\u1ea3m \u1ee9ng P-gp.<\/p>\n

N\u1ebfu nh\u01b0 ph\u1ed1i h\u1ee3p v\u1edbi Ribavirin, c\u1ea7n ch\u00fa \u00fd \u0111\u1ebfn c\u1ea3 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ri\u00eang c\u1ee7a Ribavirin.<\/p>\n

L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Sofuled 90mg\/400mg<\/h2>\n

Th\u1eadn tr\u1ecdng<\/h3>\n

Kh\u00f4ng d\u00f9ng thu\u1ed1c kh\u00e1c c\u00f3 ch\u1ee9a ch\u1ea5t Sofosbuvir.<\/p>\n

\u0110\u00e3 c\u00f3 ghi nh\u1eadn v\u1ec1 tri\u1ec7u ch\u1ee9ng ch\u1eb9n tim ho\u1eb7c ch\u1eadm nh\u1ecbp n\u1eb7ng do thu\u1ed1c.<\/p>\n

Kh\u00f4ng ph\u1ea3i thay \u0111\u1ed5i li\u1ec1u tr\u00ean b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn, gan.<\/p>\n

D\u00f9ng c\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf HMG-CoA reductase c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng b\u1ec7nh c\u01a1 hay c\u01a1 v\u00e2n b\u1ecb ti\u00eau.<\/p>\n

N\u1ebfu nhi\u1ec5m c\u1ea3 vi\u00eam gan B v\u00e0 C, b\u1ec7nh nh\u00e2n \u0111\u00f3 ph\u1ea3i \u0111\u01b0\u1ee3c theo d\u00f5i v\u00e0 h\u01b0\u1edbng d\u1eabn tr\u1ecb li\u1ec7u ri\u00eang.<\/p>\n

Tr\u1ebb < 12 tu\u1ed5i kh\u00f4ng n\u00ean d\u00f9ng Sofuled do ch\u01b0a c\u00f3 th\u00f4ng tin v\u1ec1 an to\u00e0n v\u00e0 c\u1ea3 hi\u1ec7u qu\u1ea3.<\/p>\n

Kh\u00f4ng n\u00ean d\u00f9ng c\u00f9ng nh\u1eefng thu\u1ed1c c\u1ea3m \u1ee9ng m\u1ea1nh v\u1edbi P-glycoprotein do gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c kh\u00e1ng virus vi\u00eam gan C.<\/p>\n

Ngo\u00e0i ra, t\u00ednh an to\u00e0n tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb x\u01a1 gan m\u1ea5t b\u00f9 c\u0169ng ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1.<\/p>\n

T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n

R\u1ea5t hay g\u1eb7p nh\u01b0 m\u1ec7t m\u1ecfi v\u00e0 nh\u1ee9c \u0111\u1ea7u.<\/p>\n

Hay g\u1eb7p n\u1ed5i ban.<\/p>\n

T\u01b0\u01a1ng t\u00e1c<\/h3>\n\n\n\n\n\n\n\n\n\n\n
Thu\u1ed1c<\/td>\nT\u01b0\u01a1ng t\u00e1c<\/td>\n<\/tr>\n
Thu\u1ed1c khi\u1ebfn acid d\u1ea1 d\u00e0y gi\u1ea3m<\/td>\nC\u00f3 th\u1ec3 g\u00e2y gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u1ee7a Ledipasvir<\/td>\n<\/tr>\n
Digoxin<\/td>\nKhi\u1ebfn l\u01b0\u1ee3ng Digoxin huy\u1ebft t\u0103ng<\/td>\n<\/tr>\n
C\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh, kh\u00e1ng sinh, Ritonavir\/Tipranavir, St.John\u2019s wort<\/td>\nC\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u00e1c ho\u1ea1t ch\u1ea5t c\u1ee7a Sofuled<\/td>\n<\/tr>\n
Ch\u1ea5t ch\u1ed1ng lo\u1ea1n nh\u1ecbp<\/td>\nG\u00e2y ra t\u00ecnh tr\u1ea1ng ch\u1eadm nh\u1ecbp n\u1eb7ng<\/td>\n<\/tr>\n
Tenofovir<\/td>\nG\u00e2y t\u0103ng n\u1ed3ng \u0111\u1ed9 Tenofovir<\/td>\n<\/tr>\n
C\u00e1c thu\u1ed1c HCV<\/td>\nT\u0103ng n\u1ed3ng \u0111\u1ed9 2 ho\u1ea1t ch\u1ea5t c\u1ee7a Sofuled<\/td>\n<\/tr>\n
Rosuvastatin<\/td>\nL\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 l\u01b0\u1ee3ng Rosuvastatin<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

L\u01b0u \u00fd khi d\u00f9ng cho m\u1eb9 mang thai v\u00e0 cho con b\u00fa<\/h3>\n

M\u1eb9 c\u00f3 thai hay cho con b\u00fa c\u1ea7n ph\u1ea3i \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc k\u1ef9 khi k\u00ea \u0111\u01a1n Sofuled.<\/p>\n

L\u01b0u \u00fd s\u1eed d\u1ee5ng khi \u0111ang l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n

D\u1eef li\u1ec7u \u1ea3nh h\u01b0\u1edfng c\u1ee7a Sofuled tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n c\u1ea7n t\u1ec9nh t\u00e1o trong c\u00f4ng vi\u1ec7c v\u1eabn ch\u01b0a c\u00f3.<\/p>\n

Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n

Khi qu\u00e1 li\u1ec1u, ph\u1ea3i theo d\u00f5i ng\u01b0\u1eddi b\u1ec7nh, qua s\u00e1t tri\u1ec7u ch\u1ee9ng v\u00e0 \u0111\u01b0a ra bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 v\u00e0 n\u00e2ng \u0111\u1ee1 chung.<\/p>\n

Thu\u1ed1c Sofuled 90mg\/400mg gi\u00e1 bao nhi\u00eau? mua \u1edf \u0111\u00e2u?<\/h2>\n

Thu\u1ed1c Sofuled 90mg\/400mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 thu\u1ed1c Sofuled 90mg\/400mg<\/b> c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n

K\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:<\/p>\n