{"id":95803,"date":"2024-07-31T12:27:55","date_gmt":"2024-07-31T05:27:55","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=95803"},"modified":"2025-07-24T13:30:58","modified_gmt":"2025-07-24T06:30:58","slug":"viropil","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/viropil\/","title":{"rendered":"Viropil"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, <\/b>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Viropil<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Emcure Pharmaceuticals LTD – \u1ea4n \u0110\u1ed9, s\u1ea3n ph\u1ea9m \u0111\u00e3 \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh r\u1ed9ng r\u00e3i \u1edf Vi\u1ec7t Nam.<\/b><\/p>\n

Thu\u1ed1c Viropil l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n

Th\u00e0nh ph\u1ea7n<\/h3>\n

Trong vi\u00ean u\u1ed1ng Viropil<\/b> bao g\u1ed3m c\u00e1c th\u00e0nh ph\u1ea7n nh\u01b0:<\/p>\n\n\n\n\n\n\n\n
Th\u00e0nh ph\u1ea7n<\/td>\nH\u00e0m l\u01b0\u1ee3ng<\/td>\n<\/tr>\n
Lamivudin<\/td>\n300mg<\/td>\n<\/tr>\n
Dolutegravir (\u1edf d\u1ea1ng Dolutegravir natri)<\/td>\n50mg<\/td>\n<\/tr>\n
Tenofovir Disoproxil Fumarate<\/td>\n300mg<\/td>\n<\/tr>\n
C\u00e1c ph\u1ee5 li\u1ec7u<\/td>\nV\u1eeba \u0111\u1ee7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim.<\/p>\n

Tr\u00ecnh b\u00e0y<\/h3>\n

S\u0110K: \u0110ang c\u1eadp nh\u1eadt.<\/p>\n

Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd x 30 vi\u00ean.<\/p>\n

Xu\u1ea5t x\u1ee9: \u1ea4n \u0110\u1ed9.<\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Viropil<\/h2>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n\n\n\n\n\n
Th\u00e0nh ph\u1ea7n<\/td>\nC\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/td>\n<\/tr>\n
Lamivudin v\u00e0 Tenofovir Disoproxil Fumarate<\/td>\nLamivudin l\u00e0 ho\u1ea1t ch\u1ea5t t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi dideoxynucleoside. Tenofovir Disoproxil Fumarate s\u1ebd \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh Tenofovir, ch\u1ea5t n\u00e0y t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi nucleotide c\u1ee7a adenosine monophosphat.<\/p>\n

Hai ho\u1ea1t ch\u1ea5t Lamivudin v\u00e0 Tenofovir s\u1ebd tr\u1ea3i qua qu\u00e1 tr\u00ecnh phosphoryl h\u00f3a th\u00e0nh Tenofovir diphosphat v\u00e0 Lamivudin triphosphat nh\u1edd t\u00e1c \u0111\u1ed9ng c\u1ee7a enzyme. Hai ch\u1ea5t chuy\u1ec3n h\u00f3a s\u1ebd \u1ee9c ch\u1ebf c\u1ea1nh tranh v\u1edbi ho\u1ea1t \u0111\u1ed9ng phi\u00ean m\u00e3 ng\u01b0\u1ee3c HIV-1, l\u00e0m cho chu\u1ed7i ADN k\u1ebft th\u00fac. C\u1ea3 hai ho\u1ea1t ch\u1ea5t \u0111\u1ec1u c\u00f3 th\u1ec3 ch\u1ed1ng l\u1ea1i HIV-2, HIV-1 v\u00e0 virus g\u00e2y vi\u00eam gan B.<\/td>\n<\/tr>\n

Dolutegravir<\/td>\nThu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf integrase c\u1ee7a HIV th\u00f4ng qua vi\u1ec7c g\u1eafn k\u1ebft tr\u1ef1c ti\u1ebfp l\u00ean n\u01a1i integrase ho\u1ea1t \u0111\u1ed9ng v\u00e0 \u0111\u1ed3ng th\u1eddi kh\u00f4ng cho b\u01b0\u1edbc chuy\u1ec3n c\u1ee7a qu\u00e1 tr\u00ecnh t\u00edch h\u1ee3p ADN di\u1ec5n ra. Do \u0111\u00f3 ng\u0103n ch\u1eb7n \u0111\u01b0\u1ee3c chu k\u1ef3 sao ch\u00e9p HIV.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n\n\n\n\n\n\n
Th\u00e0nh ph\u1ea7n<\/td>\nD\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/td>\n<\/tr>\n
Lamivudin<\/td>\nThu\u1ed1c s\u1ebd \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u1edbi sinh kh\u1ea3 d\u1ee5ng t\u1eeb 80-85%. U\u1ed1ng thu\u1ed1c khi \u0111ang \u0103n c\u00f3 th\u1ec3 k\u00e9o d\u00e0i tmax v\u00e0 gi\u1ea3m kho\u1ea3ng 47% Cmax. Tuy nhi\u00ean kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng v\u1edbi m\u1ee9c \u0111\u1ed9 h\u1ea5p thu thu\u1ed1c.<\/p>\n

Vd c\u1ee7a thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 1,3l\/kg. Ch\u1ec9 c\u00f3 d\u01b0\u1edbi 36% thu\u1ed1c g\u1eafn v\u00e0o protein huy\u1ebft.<\/p>\n

Thu\u1ed1c b\u1ecb chuy\u1ec3n h\u00f3a \u00edt v\u00e0 ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c th\u1ea3i ra ngo\u00e0i \u1edf d\u1ea1ng ban \u0111\u1ea7u. Th\u1eddi gian b\u00e1n h\u1ee7y t\u1eeb 5-7 gi\u1edd, c\u00f2n v\u1edbi Lamivudine triphosphate l\u00e0 22 gi\u1edd.<\/td>\n<\/tr>\n

Dolutegravir<\/td>\nSau khi u\u1ed1ng, Dolutegravir \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u1edbi tmax l\u00e0 2-3 ti\u1ebfng. U\u1ed1ng thu\u1ed1c v\u00e0o b\u1eefa \u0103n c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u1ed1c \u0111\u1ed9 nh\u01b0ng t\u0103ng m\u1ee9c \u0111\u1ed9 h\u1ea5p thu.<\/p>\n

Tr\u00ean 99% thu\u1ed1c g\u1eafn protein v\u00e0 c\u00f3 gi\u00e1 tr\u1ecb Vd t\u1eeb 17-20L.<\/p>\n

Thu\u1ed1c b\u1ecb glucuronid h\u00f3a nh\u1edd s\u1ef1 t\u00e1c \u0111\u1ed9ng c\u1ee7a UGT1A1 v\u00e0 1 ph\u1ea7n nh\u1edd CYP3A4.<\/p>\n

Th\u1eddi gian b\u00e1n th\u1ea3i cu\u1ed1i x\u1ea5p x\u1ec9 14 ti\u1ebfng, \u0111\u1ed9 thanh th\u1ea3i kho\u1ea3ng 1L\/h.<\/td>\n<\/tr>\n

Tenofovir Disoproxil Fumarate<\/td>\nThu\u1ed1c n\u00e0y sau khi u\u1ed1ng s\u1ebd \u0111\u01b0\u1ee3c chuy\u1ec3n \u0111\u1ed5i nhanh th\u00e0nh Tenofovir. Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a ch\u1ea5t n\u00e0y d\u1ef1a v\u00e0o ti\u1ec1n ch\u1ea5t ban \u0111\u1ea7u l\u00e0 25%. Gi\u00e1 tr\u1ecb AUC, Cmax s\u1ebd t\u0103ng l\u00ean khi u\u1ed1ng c\u00f9ng v\u1edbi b\u1eefa \u0103n gi\u00e0u ch\u1ea5t b\u00e9o.<\/p>\n

Vd c\u1ee7a thu\u1ed1c kho\u1ea3ng 800ml\/kg. M\u1ee9c \u0111\u1ed9 g\u1eafn protein r\u1ea5t th\u1ea5p.<\/p>\n

Tenofovir s\u1ebd \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i th\u00f4ng qua th\u1eadn, trong \u0111\u00f3 70-80% thu\u1ed1c l\u00e0 d\u1ea1ng g\u1ed1c. N\u1eeda \u0111\u1eddi b\u00e1n th\u1ea3i cu\u1ed1i c\u1ee7a thu\u1ed1c l\u00e0 12-18 gi\u1edd.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Thu\u1ed1c Viropil ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n

Thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho c\u00e1c b\u1ec7nh nh\u00e2n t\u1eeb 12 tu\u1ed5i \u0111ang b\u1ecb nhi\u1ec5m HIV-1.<\/p>\n

\"Thu\u1ed1c<\/a>
Thu\u1ed1c Viropil \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m HIV-1<\/figcaption><\/figure>\n

Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng thu\u1ed1c Viropil<\/h2>\n

Th\u00f4ng th\u01b0\u1eddng d\u00f9ng 1 vi\u00ean n\u00e9n\/ng\u00e0y.<\/p>\n

Kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 c\u00e2n n\u1eb7ng < 40kg.<\/p>\n

Kh\u00f4ng d\u00f9ng thu\u1ed1c n\u1ebfu b\u1ecb suy th\u1eadn v\u1eeba \u0111\u1ebfn n\u1eb7ng.<\/p>\n

Theo d\u00f5i c\u1ea9n th\u1eadn c\u00e1c ph\u1ea3n \u1ee9ng n\u1ebfu b\u1ec7nh nh\u00e2n suy gan t\u1eeb tr\u01b0\u1edbc.<\/p>\n

Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Viropil trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n

B\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn Lamivudin, Tenofovir, Dolutegravir hay nh\u1eefng t\u00e1 d\u01b0\u1ee3c kh\u00e1c c\u1ee7a thu\u1ed1c.<\/p>\n

D\u00f9ng c\u00f9ng v\u1edbi Dofetilide.<\/p>\n

L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Viropil<\/h2>\n

Th\u1eadn tr\u1ecdng<\/h3>\n

Kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t t\u00ednh v\u1edbi Viropil.<\/p>\n

M\u1eb7c d\u00f9 d\u00f9ng thu\u1ed1c nh\u01b0ng b\u1ec7nh nh\u00e2n v\u1eabn ph\u1ea3i d\u00f9ng nh\u1eefng bi\u1ec7n ph\u00e1p \u0111\u1ec3 ng\u0103n ng\u1eeba l\u00e2y nhi\u1ec5m HIV.<\/p>\n

B\u1ec7nh nh\u00e2n suy gan n\u1eb7ng ch\u1ec9 n\u00ean c\u00e2n nh\u1eafc d\u00f9ng thu\u1ed1c n\u1ebfu l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i.<\/p>\n

Ng\u01b0ng d\u00f9ng thu\u1ed1c n\u1ebfu b\u1ec7nh nh\u00e2n nhi\u1ec5m c\u1ea3 HBV v\u00e0 HIV.<\/p>\n

Nhi\u1ec1u ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn do thu\u1ed1c g\u00e2y ra \u0111\u00e3 \u0111\u01b0\u1ee3c th\u00f4ng b\u00e1o nh\u01b0 n\u1ed5i ban, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng c\u1ee7a c\u01a1 quan,… N\u1ebfu c\u00f3 d\u1ea5u hi\u1ec7u c\u1ee7a qu\u00e1 m\u1eabn, b\u1ec7nh nh\u00e2n c\u1ea7n ph\u1ea3i ng\u01b0ng thu\u1ed1c.<\/p>\n

Tr\u00e1nh s\u1eed d\u1ee5ng c\u00f9ng thu\u1ed1c g\u00e2y \u0111\u1ed9c th\u1eadn, n\u1ebfu kh\u00f4ng th\u1ec3 tr\u00e1nh, c\u1ea7n ph\u1ea3i theo d\u00f5i ch\u1ee9c n\u0103ng c\u1ee7a th\u1eadn th\u01b0\u1eddng xuy\u00ean.<\/p>\n

Nhi\u1ec5m toan lactic l\u00e0 bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng v\u1edbi t\u00ednh m\u1ea1ng khi d\u00f9ng thu\u1ed1c n\u00e0y.<\/p>\n

N\u1ebfu c\u00f3 d\u1ea5u hi\u1ec7u vi\u00eam t\u1ee5y, b\u1ec7nh nh\u00e2n n\u00ean ng\u01b0ng d\u00f9ng Viropil ngay.<\/p>\n

Ng\u01b0\u1eddi l\u1edbn tu\u1ed5i c\u00f3 nguy c\u01a1 suy th\u1eadn kh\u00e1 cao n\u00ean c\u1ea7n \u0111\u01b0\u1ee3c ch\u00fa \u00fd khi k\u00ea \u0111\u01a1n thu\u1ed1c.<\/p>\n

T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n\n\n\n\n\n\n\n\n\n
T\u1ea7n su\u1ea5t<\/td>\nPh\u1ea3n \u1ee9ng<\/td>\n<\/tr>\n
R\u1ea5t ph\u1ed5 bi\u1ebfn<\/td>\nGi\u1ea3m ti\u1ec3u c\u1ea7u, b\u1ea1ch c\u1ea7u trung t\u00ednh, ch\u00f3ng m\u1eb7t. \u1ec8a ch\u1ea3y, \u00f3i m\u1eeda,…<\/td>\n<\/tr>\n
Ph\u1ed5 bi\u1ebfn<\/td>\nM\u1ea5t ng\u1ee7, nh\u1ee9c \u0111\u1ea7u, ho, \u0111\u1ea7y h\u01a1i, r\u1ee5ng t\u00f3c, r\u1ed1i lo\u1ea1n c\u01a1, s\u1ed1t, m\u1ec7t m\u1ecfi,…<\/td>\n<\/tr>\n
Kh\u00f4ng ph\u1ed5 bi\u1ebfn<\/td>\nT\u0103ng enzyme gan<\/td>\n<\/tr>\n
Hi\u1ebfm<\/td>\nT\u0103ng amylase huy\u1ebft, nhi\u1ec5m toan lactic, vi\u00eam gan, suy th\u1eadn, t\u0103ng creatinin huy\u1ebft thanh,…<\/td>\n<\/tr>\n
R\u1ea5t hi\u1ebfm<\/td>\nSuy nh\u01b0\u1ee3c, \u1ed1ng th\u1eadn ho\u1ea1i t\u1eed th\u1ec3 c\u1ea5p t\u00ednh, kh\u00f3 th\u1edf, b\u1ea5t s\u1ea3n h\u1ed3ng c\u1ea7u \u0111\u01a1n thu\u1ea7n.<\/td>\n<\/tr>\n
Kh\u00f4ng r\u00f5<\/td>\nT\u1ee5t kali huy\u1ebft, gan nhi\u1ec5m m\u1ee1, vi\u00eam th\u1eadn, ti\u00eau c\u01a1 v\u00e2n, ho\u1ea1i t\u1eed x\u01b0\u01a1ng, nhuy\u1ec5n x\u01b0\u01a1ng,…<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

T\u01b0\u01a1ng t\u00e1c<\/h3>\n\n\n\n\n\n\n\n\n\n
Thu\u1ed1c<\/td>\nT\u01b0\u01a1ng t\u00e1c<\/td>\n<\/tr>\n
Didanosine<\/td>\nKh\u00f4ng n\u00ean k\u1ebft h\u1ee3p<\/td>\n<\/tr>\n
Ch\u1ea5t \u1ee9c ch\u1ebf protease<\/td>\nC\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn gi\u00e1 tr\u1ecb d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc l\u1eabn nhau khi d\u00f9ng chung. C\u1ea7n theo d\u00f5i c\u1ea3 ch\u1ee9c n\u0103ng c\u1ee7a th\u1eadn n\u1ebfu k\u1ebft h\u1ee3p<\/td>\n<\/tr>\n
Entecavir<\/td>\nKh\u00f4ng x\u1ea3y ra t\u01b0\u01a1ng t\u00e1c<\/td>\n<\/tr>\n
Adefovir dipivoxil<\/td>\nTr\u00e1nh d\u00f9ng k\u1ebft h\u1ee3p v\u1edbi Virogil<\/td>\n<\/tr>\n
Thu\u1ed1c c\u1ea3m \u1ee9ng nh\u1eefng enzyme nh\u01b0 CYP3A4, UGT1A3, BCRP, UGT1A9,…<\/td>\nC\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c \u0111\u1ed9ng c\u1ee7a Dulotegravir<\/td>\n<\/tr>\n
Thu\u1ed1c \u1ee9c ch\u1ebf nh\u1eefng enzyme CYP3A4, UGT1A3, BCRP, UGT1A9,…<\/td>\nT\u0103ng ch\u1ec9 s\u1ed1 h\u00e0m l\u01b0\u1ee3ng Dulotegravir \u1edf huy\u1ebft t\u01b0\u01a1ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

L\u01b0u \u00fd khi d\u00f9ng cho b\u00e0 b\u1ea7u v\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n

C\u00e2n nh\u1eafc k\u1ef9 khi quy\u1ebft \u0111\u1ecbnh s\u1eed d\u1ee5ng Viropil cho m\u1eb9 b\u1ea7u, ng\u01b0\u1eddi \u0111ang nu\u00f4i con b\u00fa.<\/p>\n

L\u01b0u \u00fd s\u1eed d\u1ee5ng khi \u0111ang l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n

B\u1ec7nh nh\u00e2n n\u00ean l\u01b0u \u00fd v\u00ec thu\u1ed1c c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ch\u00f3ng m\u1eb7t.<\/p>\n

Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n

Khi d\u00f9ng qu\u00e1 li\u1ec1u \u0111\u01b0\u1ee3c ch\u1ec9 d\u1eabn, b\u1ec7nh nh\u00e2n ph\u1ea3i theo d\u00f5i c\u00e1c ph\u1ea3n \u1ee9ng l\u1ea1 v\u00e0 \u0111i b\u00e1o cho b\u00e1c s\u0129 ngay khi xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u n\u00e0y.<\/p>\n

Thu\u1ed1c Viropil gi\u00e1 bao nhi\u00eau? mua \u1edf \u0111\u00e2u?<\/h2>\n

Thu\u1ed1c Viropil ch\u00ednh h\u00e3ng <\/b>hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.<\/p>\n

K\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:<\/p>\n