\n| T\u00e1 d\u01b0\u1ee3c<\/td>\n | V\u1eeba \u0111\u1ee7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n D\u1ea1ng b\u00e0o ch\u1ebf: B\u1ed9t pha ti\u00eam.<\/p>\n Tr\u00ecnh b\u00e0y<\/h3>\nS\u0110K: VD-35038-21.<\/p>\n Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 l\u1ecd.<\/p>\n Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam.<\/p>\n T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Cefopefast 2000<\/h2>\nC\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\nCefoperazone l\u00e0 1 thu\u1ed1c kh\u00e1ng sinh n\u1eb1m trong nh\u00f3m cephalosporin. N\u00f3 c\u00f3 th\u1ec3 di\u1ec7t khu\u1ea9n b\u1eb1ng c\u00e1ch g\u1eafn l\u00ean tr\u00ean t\u1ebf b\u00e0o c\u1ee7a vi khu\u1ea9n, t\u1eeb \u0111\u00f3 khi\u1ebfn s\u1ef1 t\u1ed5ng h\u1ee3p c\u1ee7a th\u00e0nh t\u1ebf b\u00e0o vi khu\u1ea9n b\u1ecb ng\u0103n ch\u1eb7n, \u0111\u1ed3ng th\u1eddi t\u0103ng ph\u00e2n chia d\u1eabn \u0111\u1ebfn ch\u1ebft c\u00e1c t\u1ebf b\u00e0o.<\/p>\n Cefoperazone mang hi\u1ec7u qu\u1ea3 t\u01b0\u01a1ng t\u1ef1 v\u1edbi Ceftazidim, tuy nhi\u00ean hi\u1ec7u qu\u1ea3 \u1edf Enterobacteriaceae hay Pseudomonas aeruginosa b\u1ecb y\u1ebfu h\u01a1n. Ngo\u00e0i ra thu\u1ed1c t\u01b0\u01a1ng \u0111\u1ed1i b\u1ec1n v\u1edbi beta-lactamase.<\/p>\n S\u1ef1 kh\u00e1ng thu\u1ed1c Cefoperazone theo 3 con \u0111\u01b0\u1eddng ch\u00ednh: C\u01a1 ch\u1ebf 1: Khi\u1ebfn h\u1ea5p thu thu\u1ed1c gi\u1ea3m xu\u1ed1ng, ho\u1eb7c l\u00e0m t\u0103ng c\u01b0\u1eddng s\u1ef1 thanh th\u1ea3i t\u1ea1i 1 s\u1ed1 ch\u1ee7ng gram \u00e2m. C\u01a1 ch\u1ebf 2: L\u00e0m thay \u0111\u1ed5i \u0111\u00edch PBP, hay xu\u1ea5t hi\u1ec7n t\u1ea1i ch\u1ee7ng gram d\u01b0\u01a1ng. C\u01a1 ch\u1ebf 3: S\u1ea3n sinh beta-lactamase ph\u1ed5 r\u1ed9ng hay c\u00f3 s\u1ef1 bi\u1ec3u hi\u1ec7n qu\u00e1 m\u1ee9c nh\u1eefng beta-lactamase x\u00e1c \u0111\u1ecbnh nhi\u1ec5m s\u1eafc th\u1ec3 \u1edf khu\u1ea9n gram \u00e2m.<\/p>\n \u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\nH\u1ea5p thu: Thu\u1ed1c kh\u00f4ng \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0o c\u01a1 th\u1ec3 khi s\u1eed d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng, do \u0111\u00f3 ph\u1ea3i d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng ti\u00eam.<\/p>\n Ph\u00e2n b\u1ed1: Thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o kh\u1eafp d\u1ecbch v\u00e0 m\u00f4 c\u1ee7a c\u01a1 th\u1ec3. Vd c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh kho\u1ea3ng 10-13 l\/kg, c\u00f2n tr\u00ean tr\u1ebb s\u01a1 sinh l\u00e0 0,5 l\/kg. Thu\u1ed1c v\u00e0o d\u1ecbch n\u00e3o t\u1ee7y r\u1ea5t k\u00e9m, tuy nhi\u00ean n\u1ebfu m\u00e0ng n\u00e3o c\u00f3 t\u00ecnh tr\u1ea1ng vi\u00eam th\u00ec l\u01b0\u1ee3ng thu\u1ed1c v\u00e0o d\u1ecbch n\u00e3o t\u1ee7y s\u1ebd nhi\u1ec1u h\u01a1n. Thu\u1ed1c c\u00f2n v\u00e0o trong s\u1eefa m\u1eb9, nhau thai.<\/p>\n Chuy\u1ec3n h\u00f3a: Thu\u1ed1c n\u1ebfu ti\u00eam b\u1eafp li\u1ec1u 1g hay 2g s\u1ebd cho Cmax l\u00e0 65 v\u00e0 97 mcg\/ml sau 1-2 ti\u1ebfng ti\u00eam. Khi d\u00f9ng ti\u00eam t\u0129nh m\u1ea1ch, Cmax nhi\u1ec1u h\u01a1n ti\u00eam b\u1eafp 2-3 l\u1ea7n, gi\u00e1 tr\u1ecb n\u00e0y \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 15-20 ph\u00fat. Th\u1eddi gian b\u00e1n h\u1ee7y \u1edf huy\u1ebft t\u01b0\u01a1ng l\u00e0 2 ti\u1ebfng. Kho\u1ea3ng 82-93% l\u01b0\u1ee3ng thu\u1ed1c g\u1eafn v\u1edbi protein.<\/p>\n Th\u1ea3i tr\u1eeb: Thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i b\u1edfi m\u1eadt l\u00e0 ch\u1ee7 y\u1ebfu, ngo\u00e0i ra c\u00f2n \u0111\u01b0\u1ee3c th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u. Sau 12-24 ti\u1ebfng, 30% li\u1ec1u l\u01b0\u1ee3ng khi th\u1ea3i tr\u1eeb \u0111ang \u1edf d\u1ea1ng g\u1ed1c.<\/p>\n Thu\u1ed1c Cefopefast 2000 ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\nThu\u1ed1c ch\u1ec9 \u0111\u1ecbnh tr\u00ean nhi\u1ec1u lo\u1ea1i b\u1ec7nh nhi\u1ec5m khu\u1ea9n nh\u01b0 nhi\u1ec5m khu\u1ea9n m\u00e1u, da-m\u00f4 m\u1ec1m, th\u1eadn-ti\u1ebft ni\u1ec7u, \u0111\u01b0\u1eddng m\u1eadt, h\u00f4 h\u1ea5p tr\u00ean-d\u01b0\u1edbi, x\u01b0\u01a1ng kh\u1edbp. Ngo\u00e0i ra c\u00f2n tr\u1ecb nhi\u1ec5m khu\u1ea9n s\u1ea3n ph\u1ee5 khoa, v\u00f9ng ch\u1eadu, ph\u00fac m\u1ea1c, nhi\u1ec5m khu\u1ea9n \u1ed5 b\u1ee5ng v\u00e0 b\u1ec7nh l\u1eadu.<\/p>\n Ch\u00fa \u00fd kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y nh\u1eb1m tr\u1ecb nhi\u1ec5m khu\u1ea9n gram d\u01b0\u01a1ng c\u00f3 th\u1ec3 ch\u1eefa \u0111\u01b0\u1ee3c b\u1eb1ng c\u00e1c cephalosporin th\u1ebf h\u1ec7 1 hay penicillin.<\/p>\n Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng thu\u1ed1c Cefopefast 2000<\/h2>\nLi\u1ec1u d\u00f9ng<\/h3>\nNg\u01b0\u1eddi l\u1edbn:<\/p>\n \n- N\u1ebfu b\u1ecb nh\u1eb9 \u0111\u1ebfn v\u1eeba th\u00ec c\u1ee9 12 ti\u1ebfng ti\u00eam cho b\u1ec7nh nh\u00e2n 1 li\u1ec1u 1-2g.<\/li>\n
- N\u1ebfu b\u1ecb n\u1eb7ng th\u00ec d\u00f9ng 12g trong 24 gi\u1edd, chia th\u00e0nh 2-4 l\u1ea7n s\u1eed d\u1ee5ng.<\/li>\n
- B\u1ec7nh nh\u00e2n c\u00f3 t\u00ecnh tr\u1ea1ng t\u1eafc m\u1eadt, b\u1ecb b\u1ec7nh gan kh\u00f4ng ti\u00eam h\u01a1n 4g thu\u1ed1c trong 24 ti\u1ebfng.<\/li>\n
- Ng\u01b0\u1eddi b\u1ecb suy gan v\u00e0 th\u1eadn d\u00f9ng 2g m\u1ed7i 24 ti\u1ebfng.<\/li>\n<\/ul>\n
Tr\u1ebb em: M\u1eb7c d\u00f9 ch\u01b0a r\u00f5 an to\u00e0n tr\u00ean tr\u1ebb nh\u1ecf < 12 tu\u1ed5i, tuy nhi\u00ean v\u1eabn c\u00f3 khuy\u1ebfn c\u00e1o d\u00f9ng tr\u00ean tr\u1ebb em v\u1edbi li\u1ec1u 25-100mg\/kg m\u1ed7i 12 ti\u1ebfng, tr\u1ebb s\u01a1 sinh d\u00f9ng 50mg\/kg m\u1ed7i 12 ti\u1ebfng, tr\u1ebb nh\u1ecf s\u1eed d\u1ee5ng 25-50mg\/kg m\u1ed7i 6-12 ti\u1ebfng. Kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng h\u01a1n 6g m\u1ed7i ng\u00e0y.<\/p>\n C\u00e1ch d\u00f9ng<\/h3>\nC\u00f3 th\u1ec3 d\u00f9ng ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch gi\u00e1n \u0111o\u1ea1n, li\u00ean t\u1ee5c ho\u1eb7c ti\u00eam b\u1eafp s\u00e2u.<\/p>\n Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Cefopefast 2000 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\nC\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ecb qu\u00e1 m\u1eabn Cefoperazone, t\u00e1 d\u01b0\u1ee3c hay nh\u1eefng thu\u1ed1c kh\u00e1c trong c\u00f9ng nh\u00f3m cephalosporin.<\/p>\n |