Th\u00e0nh ph\u1ea7n<\/span><\/h3>\nThu\u1ed1c <\/span>Colchicine Stella 1mg<\/b> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n\n- Colchicine 1mg<\/span><\/li>\n
- T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/span><\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/span><\/p>\nTr\u00ecnh b\u00e0y<\/span><\/h3>\nS\u0110K: 893115193124<\/span><\/p>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 v\u1ec9 x 10 vi\u00ean<\/span><\/p>\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/span><\/p>\nT\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Colchicine Stella 1mg<\/span><\/h2>\nC\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/span><\/h3>\nColchicine li\u00ean k\u1ebft v\u1edbi protein tubulin, ng\u0103n c\u1ea3n s\u1ef1 h\u00ecnh th\u00e0nh vi \u1ed1ng, l\u00e0 c\u1ea5u tr\u00fac quan tr\u1ecdng cho nhi\u1ec1u ch\u1ee9c n\u0103ng t\u1ebf b\u00e0o li\u00ean quan \u0111\u1ebfn vi\u00eam.<\/span><\/p>\nVi\u1ec7c ph\u00e1 v\u1ee1 vi \u1ed1ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn:<\/span><\/p>\n\n- V\u1eadn chuy\u1ec3n c\u00e1c c\u01a1 quan n\u1ed9i b\u00e0o v\u00e0 t\u00fai tinh<\/span><\/li>\n
- B\u00e0i ti\u1ebft cytokine v\u00e0 chemokine<\/span><\/li>\n
- Di c\u01b0, ph\u00e2n chia v\u00e0 \u0111i\u1ec1u h\u00f2a ho\u1ea1t \u0111\u1ed9ng di truy\u1ec1n c\u1ee7a t\u1ebf b\u00e0o<\/span><\/li>\n<\/ul>\n
Colchicine l\u00e0m gi\u1ea3m bi\u1ec3u hi\u1ec7n L-selectin tr\u00ean b\u1ea1ch c\u1ea7u trung t\u00ednh, do \u0111\u00f3 l\u00e0m gi\u1ea3m s\u1ef1 k\u1ebft d\u00ednh gi\u1eefa b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 n\u1ed9i m\u00f4.<\/span><\/p>\nColchicine c\u0169ng thay \u0111\u1ed5i s\u1ef1 ph\u00e2n b\u1ed1 E-selectin tr\u00ean t\u1ebf b\u00e0o n\u1ed9i m\u00f4, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng di chuy\u1ec3n c\u1ee7a b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0o c\u00e1c m\u00f4 b\u1ecb vi\u00eam.\u00a0<\/span><\/p>\nColchicine l\u00e0m gi\u1ea3m s\u1ef1 k\u00edch ho\u1ea1t \u0111\u1ea1i th\u1ef1c b\u00e0o do TNF-\u03b1 g\u00e2y ra v\u00e0 l\u00e0m gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng th\u1ee5 th\u1ec3 TNF-\u03b1 tr\u00ean m\u1ed9t s\u1ed1 t\u1ebf b\u00e0o.<\/span><\/p>\n\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\nH\u1ea5p thu:<\/span><\/p>\n\n- H\u1ea5p thu Colchicine nhanh qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a<\/span><\/li>\n
- Sinh kh\u1ea3 d\u1ee5ng: 45% (dao \u0111\u1ed9ng 24-88%)<\/span><\/li>\n
- Cmax: 2,5 ng\/mL (1-4,4 ng\/mL) sau 1-2 gi\u1edd (0,5-3 gi\u1edd)<\/span><\/li>\n
- D\u00f9ng v\u1edbi th\u1ee9c \u0103n gi\u1ea3m 15% m\u1ee9c \u0111\u1ed9 h\u1ea5p thu<\/span><\/li>\n<\/ul>\n
Ph\u00e2n b\u1ed1:<\/span><\/p>\n\n- Vd: 5-8 L\/kg<\/span><\/li>\n
- Colchicine ph\u00e2n b\u1ed1 \u0111\u01b0\u1ee3c v\u00e0o nhau thai v\u00e0 s\u1eefa m\u1eb9<\/span><\/li>\n
- T\u1eadp trung ch\u1ee7 y\u1ebfu \u1edf gan, th\u1eadn, m\u1eadt<\/span><\/li>\n
- L\u01b0\u1ee3ng nh\u1ecf \u1edf tim, ph\u1ed5i, ru\u1ed9t, d\u1ea1 d\u00e0y<\/span><\/li>\n<\/ul>\n
\n- Th\u1ea5p \u0111\u1ebfn trung b\u00ecnh (39%)<\/span><\/li>\n
- Ch\u1ee7 y\u1ebfu li\u00ean k\u1ebft v\u1edbi albumin<\/span><\/li>\n<\/ul>\n
Chuy\u1ec3n h\u00f3a:<\/span><\/p>\n\n- Chuy\u1ec3n h\u00f3a \u1edf gan<\/span><\/li>\n
- Ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh: 2-O-demethylcolchicine, 3-O-demethylcolchicine, colchiceine<\/span><\/li>\n<\/ul>\n
Th\u1ea3i tr\u1eeb:<\/span><\/p>\n\n- 40-65% qua n\u01b0\u1edbc ti\u1ec3u (d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c kh\u00f4ng \u0111\u1ed5i)<\/span><\/li>\n
- B\u00e0i ti\u1ebft qua m\u1eadt<\/span><\/li>\n
- T\u00bd:\u00a0 26,6-31,2 gi\u1edd (sau v\u00e0i li\u1ec1u 0,6mg x 2 l\u1ea7n\/ng\u00e0y)<\/span><\/li>\n<\/ul>\n
Thu\u1ed1c Colchicine Stella 1mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\nThu\u1ed1c Colchicine Stella 1mg<\/b> \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c \u0111\u1ee3t b\u00f9ng ph\u00e1t g\u00fat c\u1ea5p t\u00ednh <\/span>v\u00e0 ng\u0103n ng\u1eeba c\u00e1c \u0111\u1ee3t b\u00f9ng ph\u00e1t g\u00fat trong khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi allopurinol ho\u1eb7c c\u00e1c thu\u1ed1c l\u00e0m gi\u1ea3m axit uric<\/span><\/p>\n
Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a thu\u1ed1c Colchicine Stella 1mg<\/figcaption><\/figure>\nLi\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Colchicine 1mg Stella? Colchicine 1mg u\u1ed1ng l\u00fac n\u00e0o?\u00a0<\/span><\/h2>\n\n\n\n| \u0110\u1ed1i t\u01b0\u1ee3ng<\/span><\/td>\n | Li\u1ec1u d\u00f9ng<\/span><\/td>\n<\/tr>\n\n| Ng\u01b0\u1eddi l\u1edbn<\/span><\/td>\n | Ban \u0111\u1ea7u: 1mg<\/span><\/p>\n Sau m\u1ed7i 2-3 gi\u1edd: 0,5mg<\/span><\/p>\nT\u1ed1i \u0111a: 6mg\/ng\u00e0y<\/span><\/td>\n<\/tr>\n\n| K\u1ebft h\u1ee3p Allopurinol\/thu\u1ed1c g\u00e2y uric ni\u1ec7u<\/span><\/td>\n | 0.5mg x 2-3 l\u1ea7n\/ng\u00e0y<\/span><\/td>\n<\/tr>\n\n| Suy th\u1eadn nh\u1eb9\/v\u1eeba (10-50ml\/ph\u00fat)<\/span><\/td>\n | Gi\u1ea3m li\u1ec1u\/t\u0103ng kho\u1ea3ng c\u00e1ch<\/span><\/td>\n<\/tr>\n\n| Ng\u01b0\u1eddi cao tu\u1ed5i<\/span><\/td>\n | C\u1ea9n th\u1eadn<\/span><\/td>\n<\/tr>\n\n| Tr\u1ebb em<\/span><\/td>\n | Kh\u00f4ng khuy\u1ebfn c\u00e1o<\/span><\/td>\n<\/tr>\n\n| C\u00e1ch d\u00f9ng<\/span><\/td>\n | U\u1ed1ng khi \u0111au c\u1ea5p t\u00ednh, kh\u00f4ng l\u1eb7p l\u1ea1i trong 3 ng\u00e0y<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nKh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Colchicine Stella 1mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n\n- Suy th\u1eadn\/gan + thu\u1ed1c \u1ee9c ch\u1ebf P-glycoprotein\/CYP3A4 m\u1ea1nh<\/span><\/li>\n
- Ng\u01b0\u1eddi c\u00f3 c\u01a1 \u0111\u1ecba d\u1ecb \u1ee9ng kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c Colchicine Stella 1mg<\/span><\/li>\n
- Ph\u1ee5 n\u1eef \u0111ang trong thai k\u1ef3<\/span><\/li>\n
- Suy th\u1eadn n\u1eb7ng (CrCl < 10 ml\/ph\u00fat)<\/span><\/li>\n
- Th\u1ea9m t\u00e1ch m\u00e1u<\/span><\/li>\n<\/ul>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Colchicine Stella 1mg<\/span><\/h2>\nTh\u1eadn tr\u1ecdng<\/span><\/h3>\n\n- Ng\u01b0\u1eddi cao tu\u1ed5i, y\u1ebfu s\u1ee9c<\/span><\/li>\n
- Tim, gan, ti\u00eau h\u00f3a<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n m\u00e1u<\/span><\/li>\n
- Suy th\u1eadn nh\u1eb9\/v\u1eeba<\/span><\/li>\n
- Ch\u1ee9c n\u0103ng gan\/th\u1eadn b\u00ecnh th\u01b0\u1eddng (khi d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf P-glycoprotein\/CYP3A4)<\/span><\/li>\n
- Di truy\u1ec1n hi\u1ebfm g\u1eb7p\u00a0<\/span><\/li>\n
- Theo d\u00f5i \u0111\u00e1p \u1ee9ng c\u01a1 th\u1ec3 tr\u01b0\u1edbc khi l\u00e1i xe\/v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/span><\/li>\n<\/ul>\n
T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/span><\/h3>\nTh\u01b0\u1eddng g\u1eb7p<\/span><\/p>\n\n- K\u00edch \u1ee9ng d\u1ea1 d\u00e0y, \u00f3i m\u1eeda, qu\u1eb7n b\u1ee5ng<\/span><\/li>\n
- Ti\u00eau ch\u1ea3y d\u1eef d\u1ed9i, xu\u1ea5t huy\u1ebft \u0111\u01b0\u1eddng ti\u00eau h\u00f3a<\/span><\/li>\n
- Ph\u00e1t ban<\/span><\/li>\n
- Suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn (khi d\u00f9ng li\u1ec1u cao)<\/span><\/li>\n<\/ul>\n
\u00cdt g\u1eb7p: T\u1ed5n th\u01b0\u01a1ng d\u00e2y th\u1ea7n kinh ngo\u1ea1i bi\u00ean, r\u1ee5ng t\u00f3c, m\u1ea5t c\u00e2n b\u1eb1ng huy\u1ebft h\u1ecdc (khi s\u1eed d\u1ee5ng l\u00e2u d\u00e0i), s\u1ed1 l\u01b0\u1ee3ng tinh tr\u00f9ng (c\u00f3 th\u1ec3 ph\u1ee5c h\u1ed3i)<\/span><\/p>\nT\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/span><\/h3>\n\n\n\n| Thu\u1ed1c<\/span><\/td>\n | T\u01b0\u01a1ng t\u00e1c<\/span><\/td>\n<\/tr>\n\n| Kh\u00e1ng sinh (Clarithromycin, Erythromycin)<\/span><\/td>\n | T\u0103ng nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c<\/span><\/td>\n<\/tr>\n\n| \u1ee8c ch\u1ebf P-glycoprotein\/CYP3A4 m\u1ea1nh<\/span><\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/span><\/td>\n<\/tr>\n\n| Ciclosporin<\/span><\/td>\n | T\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh th\u1eadn, c\u01a1<\/span><\/td>\n<\/tr>\n\n| Vitamin B12<\/span><\/td>\n | Gi\u1ea3m h\u1ea5p thu<\/span><\/td>\n<\/tr>\n\n| Statin<\/span><\/td>\n | B\u1ec7nh c\u01a1 c\u1ea5p t\u00ednh<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nL\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef mang thai v\u00e0 ph\u1ee5 n\u1eef cho con b\u00fa<\/span><\/h3>\n\n- Ph\u1ee5 n\u1eef c\u00f3 thai: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh do nguy c\u01a1 ph\u00e1 h\u1ee7y nhi\u1ec5m s\u1eafc th\u1ec3 thai nhi.<\/span><\/li>\n
- Ph\u1ee5 n\u1eef cho con b\u00fa: Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng, Colchicin c\u00f3 th\u1ec3 \u0111i v\u00e0o s\u1eefa m\u1eb9.<\/span><\/li>\n<\/ul>\n
Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\nNguy c\u01a1:<\/span><\/p>\n\n- Li\u1ec1u g\u00e2y \u0111\u1ed9c: ~10mg<\/span><\/li>\n
- Li\u1ec1u g\u00e2y ch\u1ebft: ~65mg<\/span><\/li>\n<\/ul>\n
Tri\u1ec7u ch\u1ee9ng:<\/span><\/p>\n\n- N\u00f3ng r\u00e1t, \u0111au mi\u1ec7ng, h\u1ecdng<\/span><\/li>\n
- Bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y<\/span><\/li>\n
- M\u1ea5t n\u01b0\u1edbc, t\u1ee5t huy\u1ebft \u00e1p, s\u1ed1c<\/span><\/li>\n
- T\u1ed5n th\u01b0\u01a1ng \u0111a c\u01a1 quan (th\u1ea7n kinh, t\u1ee7y x\u01b0\u01a1ng, gan, c\u01a1, h\u00f4 h\u1ea5p, tim, th\u1eadn)<\/span><\/li>\n
- T\u1eed vong do m\u1ea5t ch\u1ee9c n\u0103ng h\u00f4 h\u1ea5p v\u00e0 tim m\u1ea1ch, nhi\u1ec5m khu\u1ea9n huy\u1ebft<\/span><\/li>\n
- R\u1ee5ng t\u00f3c, t\u0103ng b\u1ea1ch c\u1ea7u \u0111\u1ea3o ng\u01b0\u1ee3c, vi\u00eam mi\u1ec7ng (sau 10 ng\u00e0y)<\/span><\/li>\n<\/ul>\n
X\u1eed tr\u00ed:<\/span><\/p>\n\n- Theo d\u00f5i b\u1ec7nh nh\u00e2n sau khi qu\u00e1 li\u1ec1u<\/span><\/li>\n
- S\u1eed d\u1ee5ng than ho\u1ea1t t\u00ednh \u0111\u1ec3 h\u1ea5p th\u1ee5 \u0111\u1ed9c ch\u1ea5t trong d\u1ea1 d\u00e0y<\/span><\/li>\n
- Cung c\u1ea5p oxy<\/span><\/li>\n
- Duy tr\u00ec tu\u1ea7n ho\u00e0n, c\u00e2n b\u1eb1ng d\u1ecbch \u0111i\u1ec7n gi\u1ea3i<\/span><\/li>\n
- Ti\u00eam morphin sulphat 10mg (gi\u1ea3m co th\u1eaft b\u1ee5ng)<\/span><\/li>\n<\/ul>\n
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