Th\u00e0nh ph\u1ea7n<\/span><\/h3>\nThu\u1ed1c Ezecept 10\/10<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n\n- Atorvastatin 10 mg<\/span><\/li>\n
- Ezetimibe 10 mg<\/span><\/li>\n
- T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/span><\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/span><\/p>\nTr\u00ecnh b\u00e0y<\/span><\/h3>\nS\u0110K: 893110167023<\/span><\/p>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 3 v\u1ec9 x 10 vi\u00ean<\/span><\/p>\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/span><\/p>\nT\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Ezecept 10\/10<\/span><\/h2>\nC\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/span><\/h3>\nAtorvastatin:<\/span><\/p>\n\n- \u1ee8c ch\u1ebf c\u1ea1nh tranh HMG-CoA reductase, l\u00e0m gi\u1ea3m s\u1ea3n xu\u1ea5t cholesterol \u1edf gan.<\/span><\/li>\n
- Khi s\u1ed1 l\u01b0\u1ee3ng th\u1ee5 th\u1ec3 LDL tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o gan t\u0103ng l\u00ean, qu\u00e1 tr\u00ecnh thanh th\u1ea3i LDL-C t\u1eeb m\u00e1u c\u0169ng s\u1ebd \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng.<\/span><\/li>\n
- Gi\u1ea3m LDL-C, cholesterol to\u00e0n ph\u1ea7n (TC), apoB, VLDL-C v\u00e0 triglyceride (TGs).<\/span><\/li>\n
- T\u0103ng HDL-C.<\/span><\/li>\n
- Gi\u1ea3m LDL-C \u1edf b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n beta lipoprotein m\u00e1u.<\/span><\/li>\n<\/ul>\n
Ezetimibe:<\/span><\/p>\n\n- \u1ee8c ch\u1ebf m\u1ea1nh v\u00e0 ch\u1ecdn l\u1ecdc s\u1ef1 thu nh\u1eadn cholesterol t\u1eeb ru\u1ed9t<\/span><\/li>\n
- Gi\u1ea3m t\u1ed5ng l\u01b0\u1ee3ng cholesterol \u0111\u01b0\u1ee3c v\u1eadn chuy\u1ec3n \u0111\u1ebfn gan.<\/span><\/li>\n
- Th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p c\u00e1c th\u1ee5 th\u1ec3 LDL, l\u00e0m gi\u1ea3m LDL-C huy\u1ebft thanh.<\/span><\/li>\n<\/ul>\n
C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng chung:\u00a0<\/span><\/p>\n\n- Gi\u1ea3m s\u1ea3n xu\u1ea5t cholesterol (Atorvastatin).<\/span><\/li>\n
- Gi\u1ea3m h\u1ea5p thu cholesterol (Ezetimibe).<\/span><\/li>\n
- T\u0103ng lo\u1ea1i b\u1ecf cholesterol kh\u1ecfi m\u00e1u (Atorvastatin).<\/span><\/li>\n<\/ul>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n\n\n\n| \u0110\u1eb7c \u0111i\u1ec3m<\/span><\/td>\n | Atorvastatin<\/span><\/td>\n | Ezetimibe<\/span><\/td>\n<\/tr>\n\n| H\u1ea5p thu<\/span><\/td>\n | Nhanh, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh sau 1-2 gi\u1edd<\/span><\/td>\n | Nhanh, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh:\u00a0<\/span><\/p>\n\n- Ezetimibe sau 4-12 gi\u1edd<\/span><\/li>\n
- Ezetimibe-glucuronide sau 1-2 gi\u1edd<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Sinh kh\u1ea3 d\u1ee5ng<\/span><\/td>\n | Th\u1ea5p (14%)<\/span><\/td>\n | Trung b\u00ecnh<\/span><\/td>\n<\/tr>\n\n| Ph\u00e2n b\u1ed1<\/span><\/td>\n | G\u1eafn k\u1ebft cao v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (tr\u00ean 98%)<\/span><\/td>\n | G\u1eafn k\u1ebft cao v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (h\u01a1n 90%)<\/span><\/td>\n<\/tr>\n\n| Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1<\/span><\/td>\n | Kho\u1ea3ng 380 l\u00edt<\/span><\/td>\n | Kh\u00f4ng r\u00f5<\/span><\/td>\n<\/tr>\n\n| Chuy\u1ec3n h\u00f3a<\/span><\/td>\n | Chuy\u1ec3n h\u00f3a b\u1edfi CYP3A4<\/span><\/td>\n | Chuy\u1ec3n h\u00f3a nhanh th\u00e0nh ezetimibe-glucuronide<\/span><\/td>\n<\/tr>\n\n| B\u00e0i ti\u1ebft<\/span><\/td>\n | Qua m\u1eadt<\/span><\/td>\n | Ezetimibe: qua ph\u00e2n; Ezetimibe-glucuronide: qua n\u01b0\u1edbc ti\u1ec3u<\/span><\/td>\n<\/tr>\n\n| Th\u1eddi gian b\u00e1n h\u1ee7y<\/span><\/td>\n | Atorvastatin: 14 gi\u1edd; Ch\u1ea5t chuy\u1ec3n h\u00f3a: 20-30 gi\u1edd<\/span><\/td>\n | Kho\u1ea3ng 22 gi\u1edd<\/span><\/td>\n<\/tr>\n\n| \u1ea2nh h\u01b0\u1edfng c\u1ee7a th\u1ee9c \u0103n<\/span><\/td>\n | Kh\u00f4ng \u1ea3nh h\u01b0\u1edfng<\/span><\/td>\n | T\u0103ng Cmax c\u1ee7a ezetimibe 38%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nThu\u1ed1c Ezecept 10\/10 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\nB\u1ea3o v\u1ec7 tim m\u1ea1ch kh\u1ecfi c\u00e1c bi\u1ebfn ch\u1ee9ng: \u0111\u1ed9t qu\u1ef5, nh\u1ed3i m\u00e1u c\u01a1 tim, t\u1eed vong,…) v\u1edbi nh\u1eefng ng\u01b0\u1eddi t\u1eebng m\u1eafc b\u1ec7nh tim m\u1ea1ch.<\/span><\/p>\nGi\u00fap h\u1ea1 cholesterol m\u00e1u cho c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/span><\/p>\n\n- H\u1ed7 tr\u1ee3 \u0111i\u1ec1u ch\u1ec9nh ch\u1ebf \u0111\u1ed9 dinh d\u01b0\u1ee1ng:<\/span>\n
\n- Cholesterol m\u00e1u cao di truy\u1ec1n (d\u1ecb h\u1ee3p t\u1eed) ho\u1eb7c h\u1ed7n h\u1ee3p.<\/span>\n
\n- Kh\u00f4ng \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi statin \u0111\u01a1n tr\u1ecb<\/span><\/li>\n
- \u0110\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb t\u0103ng cholesterol m\u00e1u b\u1eb1ng Statin v\u00e0 Ezetimibe<\/span><\/li>\n<\/ul>\n<\/li>\n
- T\u0103ng LDL-C di truy\u1ec1n \u0111\u1ed3ng h\u1ee3p t\u1eed<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Ezecept 10\/10<\/span><\/h2>\n\n- Cholesterol m\u00e1u cao nguy\u00ean ph\u00e1t v\u00e0\/ho\u1eb7c b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch v\u00e0nh:<\/span>\n
\n- Li\u1ec1u th\u01b0\u1eddng d\u00f9ng: 1 vi\u00ean\/l\u1ea7n\/ng\u00e0y.<\/span><\/li>\n
- C\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u t\u1eeb 10\/10 mg\/ng\u00e0y \u0111\u1ebfn 80\/10 mg\/ng\u00e0y.<\/span><\/li>\n<\/ul>\n<\/li>\n
- T\u0103ng LDL-C di truy\u1ec1n \u0111\u1ed3ng h\u1ee3p t\u1eed:<\/span>\n
\n- Li\u1ec1u d\u00f9ng: 10\/10mg\/ng\u00e0y \u0111\u1ebfn 80\/10 mg\/ng\u00e0y.<\/span><\/li>\n
- C\u00f3 th\u1ec3 ph\u1ed1i h\u1ee3p Ezecept 10\/10 v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lipid m\u00e1u kh\u00e1c<\/span><\/li>\n<\/ul>\n<\/li>\n
- U\u1ed1ng Ezecept 10\/10 c\u00e1ch xa thu\u1ed1c t\u00e1ch acid m\u1eadt \u00edt nh\u1ea5t 2 gi\u1edd tr\u01b0\u1edbc ho\u1eb7c 4 gi\u1edd sau.<\/span><\/li>\n
- H\u1ea1n ch\u1ebf li\u1ec1u Ezecept 10\/10 \u1edf m\u1ee9c 20mg\/ng\u00e0y khi k\u1ebft h\u1ee3p v\u1edbi Elbasvir\/Grazoprevir.<\/span><\/li>\n
- Li\u1ec1u d\u00f9ng Ezecept th\u00f4ng th\u01b0\u1eddng v\u1eabn \u00e1p d\u1ee5ng cho ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 ng\u01b0\u1eddi suy th\u1eadn.<\/span><\/li>\n
- C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng Ezecept 10\/10 cho ng\u01b0\u1eddi suy gan.<\/span><\/li>\n
- Kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o th\u1eddi gian \u0103n khi s\u1eed d\u1ee5ng Ezecept 10\/10.<\/span><\/li>\n<\/ul>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Ezecept 10\/10 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n\n- Mang thai.<\/span><\/li>\n
- Cho con b\u00fa<\/span><\/li>\n
- Kh\u00f4ng dung n\u1ea1p v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a Ezecept 10\/10<\/strong><\/span><\/li>\n
- C\u00f3 kh\u1ea3 n\u0103ng mang thai m\u00e0 kh\u00f4ng s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3<\/span><\/li>\n
- T\u0103ng transaminase huy\u1ebft thanh kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n<\/span><\/li>\n
- \u0110i\u1ec1u tr\u1ecb vi\u00eam gan C b\u1eb1ng glecaprevir\/pibrentasvir<\/span><\/li>\n<\/ul>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Ezecept 10\/10<\/span><\/h2>\nNguy c\u01a1 ho\u1ea1i t\u1eed c\u01a1 do thu\u1ed1c:<\/span><\/p>\n\n- Nguy c\u01a1 cao h\u01a1n khi d\u00f9ng Ezecept 10\/10 v\u1edbi m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c kh\u00e1c.<\/span><\/li>\n
- B\u00e1o cho b\u00e1c s\u0129 bi\u1ebft ngay n\u1ebfu b\u1ea1n g\u1eb7p b\u1ea5t k\u1ef3 d\u1ea5u hi\u1ec7u n\u00e0o sau \u0111au nh\u1ee9c c\u01a1 b\u1eafp ho\u1eb7c m\u1ec1m y\u1ebfu c\u01a1.<\/span><\/li>\n
- C\u1ea7n ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c n\u1ebfu:<\/span>\n
\n- K\u1ebft qu\u1ea3 creatine phosphokinase t\u0103ng cao.<\/span><\/li>\n
- C\u00f3 d\u1ea5u hi\u1ec7u t\u1ed5n th\u01b0\u01a1ng c\u01a1.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
Th\u1eadn tr\u1ecdng:<\/span><\/p>\n\n- S\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng \u1edf \u0111\u1ed1i t\u01b0\u1ee3ng c\u00f3 nguy c\u01a1 ti\u00eau c\u01a1 v\u00e2n.<\/span><\/li>\n
- Fusidic acid kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng v\u1edbi thu\u1ed1c Ezecept 10\/10<\/span><\/li>\n
- C\u1ea7n theo d\u00f5i c\u1ea9n th\u1eadn khi s\u1eed d\u1ee5ng Daptomycin c\u00f9ng v\u1edbi thu\u1ed1c Ezecept 10\/10<\/span><\/li>\n
- Theo d\u00f5i ch\u1ee9c n\u0103ng gan th\u01b0\u1eddng xuy\u00ean khi d\u00f9ng thu\u1ed1c\u00a0<\/span><\/li>\n
- Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng cho b\u1ec7nh nh\u00e2n suy gan trung b\u00ecnh ho\u1eb7c n\u1eb7ng.<\/span><\/li>\n
- C\u1ea9n th\u1eadn khi d\u00f9ng v\u1edbi ciclosporin, warfarin, ho\u1eb7c fluindione.<\/span><\/li>\n
- C\u1ea7n theo d\u00f5i l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u \u1edf ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 ti\u1ec3u \u0111\u01b0\u1eddng.<\/span><\/li>\n<\/ul>\n
T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/span><\/h3>\nTh\u01b0\u1eddng g\u1eb7p<\/span><\/p>\n\n- \u0110\u1ea1i ti\u1ec7n l\u1ecfng<\/span><\/li>\n
- Nh\u1ee9c m\u1ecfi c\u01a1<\/span><\/li>\n<\/ul>\n
T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/span><\/h3>\nAtorvastatin:<\/span><\/p>\n\n- T\u0103ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng:<\/span>\n
\n- Khi s\u1eed d\u1ee5ng chung v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh: nguy c\u01a1 t\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5, bao g\u1ed3m b\u1ec7nh c\u01a1.<\/span><\/li>\n
- Khi s\u1eed d\u1ee5ng chung v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf OATP1B1: t\u0103ng sinh kh\u1ea3 d\u1ee5ng.<\/span><\/li>\n<\/ul>\n<\/li>\n
- Gi\u1ea3m n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng:<\/span>\n
\n- Khi s\u1eed d\u1ee5ng chung v\u1edbi c\u00e1c ch\u1ea5t g\u00e2y c\u1ea3m \u1ee9ng CYP3A4.<\/span><\/li>\n<\/ul>\n<\/li>\n
- T\u0103ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c:<\/span>\n
\n- Digoxin<\/span><\/li>\n
- Norethindrone<\/span><\/li>\n
- Ethinyl estradiol<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
Ezetimibe:<\/span><\/p>\n\n- \u00cdt \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9:<\/span>\n
\n- C\u00e1c statin kh\u00e1c<\/span><\/li>\n
- D\u1eabn xu\u1ea5t axit fibric<\/span><\/li>\n
- Digoxin<\/span><\/li>\n
- Glipizide<\/span><\/li>\n
- Warfarin<\/span><\/li>\n
- Thu\u1ed1c tr\u00e1nh thai ba pha<\/span><\/li>\n<\/ul>\n<\/li>\n
- T\u0103ng sinh kh\u1ea3 d\u1ee5ng:<\/span>\n
\n- Gemfibrozil<\/span><\/li>\n
- Fenofibrate (\u00fd ngh\u0129a l\u00e2m s\u00e0ng kh\u00f4ng \u0111\u00e1ng k\u1ec3)<\/span><\/li>\n<\/ul>\n<\/li>\n
- Gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng:<\/span>\n
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