Th\u00e0nh ph\u1ea7n<\/span><\/h3>\nThu\u1ed1c Vytostad 10\/20<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n\n- Ezetimibe 10 mg<\/span><\/li>\n
- Simvastatin 20 mg<\/span><\/li>\n
- T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean\u00a0<\/span><\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/span><\/p>\nTr\u00ecnh b\u00e0y<\/span><\/h3>\nS\u0110K: 893110225423<\/span><\/p>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 30 vi\u00ean<\/span><\/p>\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam\u00a0<\/span><\/p>\nT\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Vytostad 10\/20<\/span><\/h2>\nC\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/span><\/h3>\nEzetimibe:<\/span><\/p>\n\n- Ezetimibe t\u00e1c \u0111\u1ed9ng ch\u1ecdn l\u1ecdc v\u00e0o ru\u1ed9t non, h\u1ea1n ch\u1ebf s\u1ef1 h\u1ea5p thu cholesterol v\u00e0 phytosterol.<\/span><\/li>\n
- M\u1ee5c ti\u00eau ch\u00ednh l\u00e0 protein NPC1L1, gi\u00fap v\u1eadn chuy\u1ec3n cholesterol v\u00e0o t\u1ebf b\u00e0o ru\u1ed9t.<\/span><\/li>\n
- Ezetimibe ho\u1ea1t \u0111\u1ed9ng \u1edf r\u00eca b\u00e0n ch\u1ea3i c\u1ee7a ru\u1ed9t non v\u00e0 ng\u0103n ch\u1eb7n protein NPC1L1.<\/span><\/li>\n<\/ul>\n
Simvastatin<\/span><\/p>\n\n- Simvastatin l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t \u0111\u01b0\u1ee3c chuy\u1ec3n \u0111\u1ed5i th\u00e0nh beta, delta-dihydroxy acid c\u00f3 ho\u1ea1t t\u00ednh.<\/span><\/li>\n
- H\u1ee3p ch\u1ea5t n\u00e0y g\u1eafn v\u00e0o enzyme HMG-CoA reductase v\u00e0 ng\u0103n ch\u1eb7n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a enzyme n\u00e0y, d\u1eabn \u0111\u1ebfn gi\u1ea3m s\u1ea3n xu\u1ea5t cholesterol<\/span><\/li>\n
- Simvastatin ho\u1ea1t \u0111\u1ed9ng ch\u1ee7 y\u1ebfu \u1edf gan, n\u01a1i n\u1ed3ng \u0111\u1ed9 cholesterol th\u1ea5p s\u1ebd k\u00edch th\u00edch:<\/span>\n
\n- H\u1ea5p thu LDL (lipoprotein m\u1eadt \u0111\u1ed9 th\u1ea5p)<\/span><\/li>\n
- \u1ee8c ch\u1ebf t\u1ed5ng h\u1ee3p VLDL (lipoprotein m\u1eadt \u0111\u1ed9 r\u1ea5t th\u1ea5p)<\/span><\/li>\n<\/ul>\n<\/li>\n
- Hi\u1ec7u qu\u1ea3:<\/span>\n
\n- Gi\u1ea3m LDL v\u00e0 VLDL trong huy\u1ebft t\u01b0\u01a1ng<\/span><\/li>\n
- Duy tr\u00ec l\u01b0\u1ee3ng mevalonate c\u1ea7n thi\u1ebft cho c\u01a1 th\u1ec3<\/span><\/li>\n
- An to\u00e0n, kh\u00f4ng g\u00e2y t\u00edch t\u1ee5 sterol \u0111\u1ed9c h\u1ea1i\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\nH\u1ea5p thu:<\/span><\/p>\n\n- Simvastatin:<\/span>\n
\n- Cmax \u0111\u1ea1t sau 1,3 \u0111\u1ebfn 2,4 gi\u1edd.<\/span><\/li>\n
- T\u00ednh tuy\u1ebfn t\u00ednh c\u1ee7a AUC khi t\u0103ng li\u1ec1u l\u00ean t\u1edbi 120 mg.<\/span><\/li>\n<\/ul>\n<\/li>\n
- Ezetimibe:<\/span>\n
\n- Cmax \u0111\u1ea1t sau 4 \u0111\u1ebfn 12 gi\u1edd.<\/span><\/li>\n
- Cmax t\u0103ng 38% khi \u0103n nhi\u1ec1u ch\u1ea5t b\u00e9o.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
Ph\u00e2n b\u1ed1:<\/span><\/p>\n\n- Simvastatin:<\/span>\n
\n- Simvastatin ph\u1ea3i \u0111\u01b0\u1ee3c gan x\u1eed l\u00fd tr\u01b0\u1edbc khi \u0111i v\u00e0o m\u00e1u.<\/span><\/li>\n
- N\u1ed3ng \u0111\u1ed9 \u1edf gan cao h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi c\u00e1c m\u00f4 kh\u00f4ng ph\u1ea3i m\u1ee5c ti\u00eau.<\/span><\/li>\n
- Sinh kh\u1ea3 d\u1ee5ng to\u00e0n th\u00e2n th\u1ea5p.<\/span><\/li>\n<\/ul>\n<\/li>\n
- Ezetimibe:<\/span>\n
\n- Ezetimibe v\u00e0 ph\u1ee9c h\u1ee3p ezetimibe-glucuronide li\u00ean k\u1ebft v\u1edbi protein h\u01a1n 90%.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
Chuy\u1ec3n h\u00f3a:<\/span><\/p>\n\n- Simvastatin:<\/span>\n
\n- Chuy\u1ec3n h\u00f3a th\u00e0nh d\u1ea1ng \u03b2-hydroxyaxit c\u00f3 ho\u1ea1t t\u00ednh.<\/span><\/li>\n
- Chuy\u1ec3n h\u00f3a oxy h\u00f3a \u1edf gan ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n qua trung gian CYP3A4 v\u00e0 CYP3A5.<\/span><\/li>\n<\/ul>\n<\/li>\n
- Ezetimibe:<\/span>\n
\n- Chuy\u1ec3n h\u00f3a nhanh ch\u00f3ng th\u00e0nh ezetimibe-glucuronide.<\/span><\/li>\n
- CYP450 chuy\u1ec3n h\u00f3a ezetimibe, nh\u01b0ng n\u00f3 c\u00f3 \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1c.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
Th\u1ea3i tr\u1eeb:<\/span><\/p>\n\n- Simvastatin:<\/span>\n
\n- B\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u (13%) v\u00e0 ph\u00e2n (60%).<\/span><\/li>\n
- N\u1eeda \u0111\u1eddi: 4,85 gi\u1edd.<\/span><\/li>\n<\/ul>\n<\/li>\n
- Ezetimibe:<\/span>\n
\n- Qua ph\u00e2n: Ezetimibe<\/span><\/li>\n
- Qua n\u01b0\u1edbc ti\u1ec3u: Ezetimibe-glucuronide<\/span><\/li>\n
- T\u00bd t\u01b0\u01a1ng t\u1ef1 nhau: 22 gi\u1edd.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
Thu\u1ed1c Vytostad 10\/20 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\nThu\u1ed1c Vytostad 10\/20<\/strong> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u0103ng lipid m\u00e1u nguy\u00ean ph\u00e1t (d\u1ecb h\u1ee3p t\u1eed c\u00f3 t\u00ednh ch\u1ea5t gia \u0111\u00ecnh v\u00e0 kh\u00f4ng c\u00f3 t\u00ednh ch\u1ea5t gia \u0111\u00ecnh), t\u0103ng lipid m\u00e1u h\u1ed7n h\u1ee3p v\u00e0 t\u0103ng cholesterol m\u00e1u gia \u0111\u00ecnh \u0111\u1ed3ng h\u1ee3p t\u1eed.<\/span><\/p>\nLi\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Vytostad 10\/20<\/span><\/h2>\nLi\u1ec1u b\u00ecnh th\u01b0\u1eddng:<\/span><\/p>\n\n- U\u1ed1ng v\u00e0o bu\u1ed5i t\u1ed1i 1 vi\u00ean Vytostad<\/strong> 10\/20\/ng\u00e0y.<\/span><\/li>\n
- Kh\u1edfi \u0111i\u1ec3m t\u1eeb 10\/10 mg \u0111\u1ebfn 10\/40 mg\/ng\u00e0y.<\/span><\/li>\n
- X\u00e9t nghi\u1ec7m l\u1ea1i l\u01b0\u1ee3ng m\u1ee1 m\u00e1u sau 14 ng\u00e0y v\u00e0 thay \u0111\u1ed5i li\u1ec1u l\u01b0\u1ee3ng n\u1ebfu c\u1ea7n<\/span><\/li>\n<\/ul>\n
Ch\u1ec9 d\u00f9ng li\u1ec1u 10\/80 mg trong tr\u01b0\u1eddng h\u1ee3p c\u1ee5 th\u1ec3:<\/span><\/p>\n\n- Nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 d\u00f9ng li\u1ec1u n\u00e0y m\u1ea1n t\u00ednh (1 n\u0103m) m\u00e0 kh\u00f4ng c\u00f3 \u0111\u1ed9c t\u00ednh tr\u00ean c\u01a1.<\/span><\/li>\n
- T\u0103ng guy c\u01a1 m\u1eafc b\u1ec7nh c\u01a1 khi thay \u0111\u1ed5i li\u1ec1u t\u1eeb 10\/40 mg l\u00ean 10\/80 mg<\/span><\/li>\n<\/ul>\n
D\u00f9ng chung v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c:<\/span><\/p>\n\n- T\u1ed1i \u0111a 1 vi\u00ean Vytostad 10\/10\/ng\u00e0y: Dronedarone, Verapamil, Diltiazem<\/span><\/li>\n
- T\u1ed1i \u0111a 1 vi\u00ean Vytostad 10\/20\/ng\u00e0y: Amlodipin, Amiodarone, Ranolazine<\/span><\/li>\n
- C\u00e1ch xa th\u1eddi \u0111i\u1ec3m u\u1ed1ng thu\u1ed1c Vytostad 10\/20 v\u1edbi th\u1eddi \u0111i\u1ec3m s\u1eed d\u1ee5ng thu\u1ed1c h\u1ea5p th\u1ee5 acid m\u1eadt \u00edt nh\u1ea5t 2 gi\u1edd tr\u01b0\u1edbc ho\u1eb7c 4 gi\u1edd sau.<\/span><\/li>\n<\/ul>\n
Ng\u01b0\u1eddi c\u00f3 m\u1ee1 m\u00e1u cao di truy\u1ec1n th\u1ec3 \u0111\u1ed3ng h\u1ee3p t\u1eed<\/span><\/p>\n\n- Li\u1ec1u khuy\u00ean d\u00f9ng: 10\/40 mg\/ng\u00e0y v\u00e0o bu\u1ed5i t\u1ed1i.<\/span><\/li>\n
- Ph\u1ed1i h\u1ee3p gi\u1ea3m cholesterol v\u1edbi c\u00e1c bi\u1ec7n ph\u00e1p kh\u00e1c<\/span><\/li>\n<\/ul>\n
Ng\u01b0\u1eddi c\u00f3 b\u1ec7nh th\u1eadn m\u00e3n t\u00ednh\/suy th\u1eadn<\/span><\/p>\n\n- Li\u1ec1u t\u1ed1i \u0111a 1 vi\u00ean\/ng\u00e0y.<\/span><\/li>\n
- C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng li\u1ec1u l\u01b0\u1ee3ng l\u1edbn h\u01a1n<\/span><\/li>\n<\/ul>\n
Ng\u01b0\u1eddi gi\u00e0: D\u00f9ng 1 vi\u00ean Vytostad 10\/20\/ng\u00e0y.<\/span><\/p>\nKh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Vytostad 10\/20 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n\n- B\u1ec7nh gan th\u1ec3 ho\u1ea1t \u0111\u1ed9ng<\/span><\/li>\n
- D\u00f9ng song song v\u1edbi c\u00e1c thu\u1ed1c:\u00a0<\/span>\n
\n- Danazol<\/span><\/li>\n
- Gemfibrozil<\/span><\/li>\n
- \u1ee8c ch\u1ebf m\u1ea1nh CYP3A4<\/span><\/li>\n
- Cyclosporin<\/span><\/li>\n<\/ul>\n<\/li>\n
- N\u1eef gi\u1edbi c\u00f3 th\u1ec3 mang thai ho\u1eb7c \u0111ang mang thai\u00a0<\/span><\/li>\n
- D\u1ecb \u1ee9ng v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c Vytostad 10\/20<\/span><\/li>\n
- Men gan cao li\u00ean t\u1ee5c kh\u00f4ng r\u00f5 l\u00fd do<\/span><\/li>\n
- M\u1eb9 \u0111ang cho tr\u1ebb b\u00fa<\/span><\/li>\n<\/ul>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Vytostad 10\/20<\/span><\/h2>\nTh\u1eadn tr\u1ecdng<\/span><\/h3>\n\n- Kh\u1ea3 n\u0103ng m\u1eafc b\u1ec7nh c\u01a1:<\/span>\n
\n- Th\u00f4ng b\u00e1o l\u1eadp t\u1ee9c n\u1ebfu xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u nh\u01b0 \u0111au nh\u1ee9c c\u01a1 b\u1eafp, c\u0103ng c\u1ee9ng c\u01a1 ho\u1eb7c suy gi\u1ea3m s\u1ee9c m\u1ea1nh c\u01a1 b\u1eafp<\/span><\/li>\n
- Kh\u00e1m \u0111\u1ecbnh k\u1ef3 n\u1ed3ng \u0111\u1ed9 creatine kinase (CK)<\/span><\/li>\n
- D\u1eebng s\u1eed d\u1ee5ng Vytostad 10\/20 n\u1ebfu CPK t\u0103ng ho\u1eb7c nghi ng\u1edd c\u00f3 v\u1ea5n \u0111\u1ec1 v\u1ec1 c\u01a1 b\u1eafp<\/span><\/li>\n<\/ul>\n<\/li>\n
- Gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn nhanh ch\u00f3ng: T\u1ea1m th\u1eddi d\u1eebng Vytostad 10\/20<\/span><\/li>\n
- V\u1ea5n \u0111\u1ec1 v\u1ec1 gan:\u00a0<\/span>\n
\n- Ki\u1ec3m tra s\u1ee9c kh\u1ecfe gan tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng<\/span><\/li>\n
- Ng\u01b0ng d\u00f9ng thu\u1ed1c n\u1ebfu ch\u1ee9c n\u0103ng gan b\u1ecb \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng<\/span><\/li>\n
- Th\u1eadn tr\u1ecdng ng\u01b0\u1eddi c\u00f3 th\u00f3i quen u\u1ed1ng r\u01b0\u1ee3u bia ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh l\u00fd v\u1ec1 gan<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/span><\/h3>\nH\u1ec7 tim m\u1ea1ch:<\/span><\/p>\n\n- Gi\u1ea3m PLT, thi\u1ebfu m\u00e1u<\/span><\/li>\n<\/ul>\n
H\u1ec7 h\u00f4 h\u1ea5p:<\/span><\/p>\n\n- S\u1ed1c ph\u1ea3n v\u1ec7<\/span><\/li>\n<\/ul>\n
H\u1ec7 ti\u00eau h\u00f3a:<\/span><\/p>\n\n- M\u1ea5t c\u1ea3m gi\u00e1c mu\u1ed1n \u0103n<\/span><\/li>\n
- \u0110au d\u1ea1 d\u00e0y, kh\u00f3 ch\u1ecbu v\u00f9ng b\u1ee5ng, \u0111au ph\u1ea7n tr\u00ean b\u1ee5ng, kh\u00f3 ti\u00eau h\u00f3a, ch\u01b0\u1edbng b\u1ee5ng, bu\u1ed3n n\u00f4n, \u00f3i m\u1eeda, \u0111i ngo\u00e0i l\u1ecfng, mi\u1ec7ng kh\u00f4, tr\u00e0o ng\u01b0\u1ee3c axit<\/span><\/li>\n
- B\u00ed \u0111\u1ea1i ti\u1ec7n, vi\u00eam t\u1ee5y, vi\u00eam d\u1ea1 d\u00e0y<\/span><\/li>\n<\/ul>\n