{"id":59875,"date":"2023-11-30T09:54:57","date_gmt":"2023-11-30T02:54:57","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=59875"},"modified":"2025-07-24T13:44:01","modified_gmt":"2025-07-24T06:44:01","slug":"maxxflame-c","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/maxxflame-c\/","title":{"rendered":"Maxxflame-C"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Maxxflame-C<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Ampharco U.S.A, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-25620-16<\/b>.<\/span><\/p>\n

Maxxflame-C l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n

Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n

Thu\u1ed1c Maxxflame-C<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n trong m\u1ed7i vi\u00ean nang c\u1ee9ng:<\/span><\/p>\n

200mg ho\u1ea1t ch\u1ea5t Celecoxib<\/span><\/p>\n

T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean bao g\u1ed3m: Lactose monohydrat, povidon, natri laurylsulfat, natri croscarmellose, magnesi stearat.<\/span><\/p>\n

D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang c\u1ee9ng<\/span><\/p>\n

Tr\u00ecnh b\u00e0y<\/span><\/h3>\n

S\u0110K: VD-25620-16<\/span><\/p>\n

Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 t\u00fai nh\u00f4m ch\u1ee9a 10 v\u1ec9 x 10 vi\u00ean<\/span><\/p>\n

Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/span><\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Maxxflame-C<\/span><\/h2>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\n

Celecoxid<\/strong> l\u00e0 thu\u1ed1c kh\u00e1ng vi\u00eam nh\u00f3m Nsaid (kh\u00f4ng steroid), \u1ee9c ch\u1ebf cyclooxygenase-2 (COX-2) ch\u1ecdn l\u1ecdc, c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m nguy c\u01a1 g\u00e2y xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a h\u01a1n so v\u1edbi c\u00e1c thu\u1ed1c c\u00f9ng nh\u00f3m kh\u00e1c. Kh\u00f4ng gi\u1ed1ng nh\u01b0 h\u1ea7u h\u1ebft c\u00e1c NSAID \u1ee9c ch\u1ebf c\u1ea3 hai lo\u1ea1i cyclooxygenase (COX-1 v\u00e0 COX-2), celecoxib l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc kh\u00f4ng c\u1ea1nh tranh c\u1ee7a enzyme cyclooxygenase-2 (COX-2). S\u1ef1 \u1ee9c ch\u1ebf enzyme n\u00e0y l\u00e0m gi\u1ea3m qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a bao g\u1ed3m prostaglandin E2 ( PGE2 ), prostacyclin ( PGI2 ), Thromboxane ( TXA2 ), prostaglandin D2 ( PGD2 ) v\u00e0 prostaglandin F2 ( PGF2). Celecoxib \u00edt g\u00e2y nguy c\u01a1 lo\u00e9t h\u01a1n c\u00e1c NSAID kh\u00e1c do t\u00e1c d\u1ee5ng c\u1ee7a n\u00f3 \u0111\u1ed1i v\u1edbi qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p prostaglandin \u1edf ni\u00eam m\u1ea1c d\u1ea1 d\u00e0y gi\u1ea3m. Ngo\u00e0i ra, celecoxib \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf enzyme carbonic anhydrase 2 v\u00e0 3, t\u0103ng c\u01b0\u1eddng h\u01a1n n\u1eefa t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0. Celecoxib c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, n\u00ean c\u00f3 th\u1ec3 l\u00e0m t\u0103ng c\u00e1c nguy c\u01a1 x\u1ea3y ra c\u00e1c bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i do \u1ee9c ch\u1ebf COX-2 l\u00e0 do t\u00e1c d\u1ee5ng co m\u1ea1ch c\u1ee7a Thromboxane A2, d\u1eabn \u0111\u1ebfn t\u0103ng c\u01b0\u1eddng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, t\u00ecnh tr\u1ea1ng n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t khi t\u00e1c d\u1ee5ng c\u1ee7a prostacyclin , m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, b\u1ecb \u1ee9c ch\u1ebf th\u00f4ng qua s\u1ef1 \u1ee9c ch\u1ebf COX-2.<\/span><\/p>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n

H\u1ea5p th\u1ee5: Celecoxib \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. Khi d\u00f9ng m\u1ed9t li\u1ec1u u\u1ed1ng duy nh\u1ea5t 200 mg cho \u0111\u1ed1i t\u01b0\u1ee3ng nghi\u00ean c\u1ee9u kh\u1ecfe m\u1ea1nh, n\u1ed3ng \u0111\u1ed9 celecoxib trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u1ec9nh trong v\u00f2ng 3 gi\u1edd.<\/span><\/p>\n

Ph\u00e2n b\u1ed1: Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 bi\u1ec3u ki\u1ebfn \u200b\u200bc\u1ee7a celecoxib \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh (Vss\/F) l\u00e0 kho\u1ea3ng 429L, \u0111i\u1ec1u n\u00e0y cho th\u1ea5y s\u1ef1 ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i v\u00e0o c\u00e1c m\u00f4 kh\u00e1c nhau. Celecoxib kh\u00f4ng li\u00ean k\u1ebft t\u1ed1t v\u1edbi h\u1ed3ng c\u1ea7u.\u00a0<\/span><\/p>\n

Chuy\u1ec3n h\u00f3a: Ph\u1ea7n l\u1edbn qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a celecoxib \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n qua trung gian cytochrome P450 2C9 \u1edf gan v\u1edbi m\u1ed9t ph\u1ea7n \u0111\u00f3ng g\u00f3p t\u1eeb CYP3A4 v\u00e0 CYP2C8 v\u00e0 c\u00f3 th\u1ec3 c\u00f3 \u0111\u00f3ng g\u00f3p t\u1eeb CYP2D6. N\u00f3 \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1eb1ng c\u00e1ch bi\u1ebfn \u0111\u1ed5i sinh h\u1ecdc th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a axit cacboxylic v\u00e0 glucuronide. Ba ch\u1ea5t chuy\u1ec3n h\u00f3a, r\u01b0\u1ee3u b\u1eadc m\u1ed9t, axit cacboxylic v\u00e0 li\u00ean h\u1ee3p glucuronide, \u0111\u00e3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong huy\u1ebft t\u01b0\u01a1ng ng\u01b0\u1eddi sau khi d\u00f9ng celecoxib.<\/span><\/p>\n

Th\u1ea3i tr\u1eeb: elecoxib \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua chuy\u1ec3n h\u00f3a \u1edf gan v\u1edbi m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf (<3%) thu\u1ed1c kh\u00f4ng chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong c\u1ea3 n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n. Kho\u1ea3ng 57% li\u1ec1u u\u1ed1ng celecoxib \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua ph\u00e2n v\u00e0 27% \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a. Ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh trong n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a axit cacboxylic (73%). L\u01b0\u1ee3ng glucuronide trong n\u01b0\u1edbc ti\u1ec3u \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 th\u1ea5p.<\/span><\/p>\n

Thu\u1ed1c Maxxflame-C \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n

Maxxflame-C \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p<\/span><\/p>\n