{"id":58261,"date":"2023-11-21T10:34:25","date_gmt":"2023-11-21T03:34:25","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&#038;p=58261"},"modified":"2025-07-24T13:44:13","modified_gmt":"2025-07-24T06:44:13","slug":"thuoc-xigduo-xr-10mg-1000mg","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/thuoc-xigduo-xr-10mg-1000mg\/","title":{"rendered":"Xigduo XR 10mg\/1000mg"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <a href=\"https:\/\/hmm88i.com\/drug\/thuoc-xigduo-xr-10mg-1000mg\/\">Xigduo XR 10mg\/1000mg<\/a> v\u1edbi th\u00e0nh ph\u1ea7n ch\u1ee9a Metforminv\u00e0 Dapagliflozin, l\u00e0 thu\u1ed1c ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng tu\u00fdp II, do AstraZeneca Pharmaceuticals LP s\u1ea3n xu\u1ea5t v\u00e0 ph\u00e2n ph\u1ed1i, v\u1edbi s\u1ed1 l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN3-216-19.\u00a0<\/b><\/p>\n<h2><span style=\"font-weight: 400;\">Xigduo XR 10mg\/1000mg l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n<p><span style=\"font-weight: 400;\"><strong>Thu\u1ed1c<\/strong> <strong>Xigduo XR 10mg\/1000mg<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Dapagliflozin (d\u01b0\u1edbi d\u1ea1ng dapagliflozin propanediol monohydrat): 10mg.<\/span><\/li>\n<li>Metformin (d\u01b0\u1edbi d\u1ea1ng metformin hydroclorid): 1000mg.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c: v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">D\u1ea1ng b\u00e0o ch\u1ebf: i\u00ean n\u00e9n bao phim ph\u00f3ng th\u00edch k\u00e9o d\u00e0i.\u00a0<\/span><\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p><span style=\"font-weight: 400;\">S\u0110K: VN3-216-19.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 4 v\u1ec9 x 7 vi\u00ean.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Xu\u1ea5t x\u1ee9: AstraZeneca Pharmaceuticals LP &#8211; Anh.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Xigduo XR 10mg\/1000mg c\u00f3 t\u00e1c d\u1ee5ng g\u00ec?\u00a0<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\n<p>Xigduo XR ph\u1ed1i h\u1ee3p 2 thu\u1ed1c ch\u1ed1ng t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft v\u1edbi c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng b\u1ed5 sung l\u00e0m c\u1ea3i thi\u1ec7n ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00fdp 2: Dapagliflozin, m\u1ed9t thu\u1ed1c \u1ee9c ch\u1ebf k\u00eanh \u0111\u1ed3ng v\u1eadn chuy\u1ec3n natri &#8211; glucose 2 (SGLT2), v\u00e0 metformin hydroclorid, m\u1ed9t thu\u1ed1c thu\u1ed1c thu\u1ed9c nh\u00f3m biguanid.<\/p>\n<p><em>Dapagliflozin<\/em><\/p>\n<p>K\u00eanh \u0111\u1ed3ng v\u1eadn chuy\u1ec3n natri &#8211; glucose 2 (SGLT2) hi\u1ec7n di\u1ec7n trong c\u00e1c \u1ed1ng th\u1eadn g\u1ea7n, ch\u1ecbu tr\u00e1ch nhi\u1ec7m cho ph\u1ea7n l\u1edbn s\u1ef1 t\u00e1i h\u1ea5p thu glucose \u0111\u01b0\u1ee3c l\u1ecdc t\u1eeb \u1ed1ng th\u1eadn. Dapagliflozin l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf SGLT2. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf SGLT2, dapagliflozin l\u00e0m gi\u1ea3m s\u1ef1 t\u00e1i h\u1ea5p thu glucose \u0111\u00e3 l\u1ecdc v\u00e0 l\u00e0m gi\u1ea3m ng\u01b0\u1ee1ng glucose \u1edf th\u1eadn v\u00e0 do \u0111\u00f3 l\u00e0m t\u0103ng b\u00e0i ti\u1ebft glucose qua n\u01b0\u1edbc ti\u1ec3u.<\/p>\n<p><em>Metformin hydroclorid<\/em><\/p>\n<p>Metformin c\u1ea3i thi\u1ec7n dung n\u1ea1p glucose \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00fdp 2, l\u00e0m gi\u1ea3m glucose huy\u1ebft t\u01b0\u01a1ng khi \u0111\u00f3i v\u00e0 sau b\u1eefa \u0103n. Metformin l\u00e0m gi\u1ea3m s\u1ea3n xu\u1ea5t glucose trong gan, l\u00e0m gi\u1ea3m s\u1ef1 h\u1ea5p thu \u0111\u01b0\u1eddng glucose \u1edf ru\u1ed9t v\u00e0 c\u1ea3i thi\u1ec7n s\u1ef1 nh\u1ea1y c\u1ea3m v\u1edbi insulin b\u1eb1ng c\u00e1ch t\u0103ng h\u1ea5p thu v\u00e0 s\u1eed d\u1ee5ng glucose \u1edf ngo\u1ea1i vi. Metformin kh\u00f4ng g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00fdp 2 ho\u1eb7c \u1edf nh\u1eefng ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh, ngo\u1ea1i tr\u1eeb nh\u1eefng tr\u01b0\u1eddng h\u1ee3p b\u1ea5t th\u01b0\u1eddng v\u00e0 kh\u00f4ng g\u00e2y t\u0103ng insulin huy\u1ebft. V\u1edbi li\u1ec7u ph\u00e1p metformin, s\u1ef1 ti\u1ebft insulin v\u1eabn kh\u00f4ng thay \u0111\u1ed5i trong khi m\u1ee9c insulin khi \u0111\u00f3i v\u00e0 \u0111\u00e1p \u1ee9ng insulin huy\u1ebft t\u01b0\u01a1ng trong m\u1ed9t ng\u00e0y th\u1ef1c s\u1ef1 c\u00f3 th\u1ec3 gi\u1ea3m.<\/p>\n<h3><span style=\"font-weight: 400;\">\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 50%; text-align: center;\">Metformin<\/td>\n<td style=\"width: 50%; text-align: center;\">Dapagliflozin<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50%;\">H\u1ea5p thu: Metformin h\u1ea5p thu ch\u1eadm v\u00e0 kh\u00f4ng ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, ch\u1ee7 y\u1ebfu l\u00e0 \u1edf ru\u1ed9t non. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 50 &#8211; 60% khi d\u00f9ng li\u1ec1u 500mg l\u00fac \u0111\u00f3i. N\u1ebfu u\u1ed1ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u1ed9 v\u00e0 t\u1ed1c \u0111\u1ed9 h\u1ea5p thu thu\u1ed1c. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a thu\u1ed1c \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 24 &#8211; 48 gi\u1edd.<\/p>\n<p>Ph\u00e2n b\u1ed1: Thu\u1ed1c ph\u00e2n b\u1ed1 nhanh v\u00e0 ch\u1ee7 y\u1ebfu v\u00e0o c\u00e1c m\u00f4 v\u00e0 d\u1ecbch ngo\u1ea1i b\u00e0o trong c\u01a1 th\u1ec3, m\u1ed9t ph\u1ea7n \u1edf h\u1ed3ng c\u1ea7u v\u00e0 c\u00e1c khoang m\u00f4 s\u00e2u. Metformin g\u1ea7n nh\u01b0 kh\u00f4ng li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 bi\u1ec3u ki\u1ebfn \u200b\u200bsau khi u\u1ed1ng m\u1ed9t li\u1ec1u metformin 850mg trung b\u00ecnh l\u00e0 654 \u00b1 358 L.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Metformin kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a b\u01b0\u1edbc m\u1ed9t qua gan v\u00e0 hi\u1ec7n t\u1ea1i ch\u01b0a c\u00f3 ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0o c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf ng\u01b0\u1eddi.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn v\u00e0 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft d\u01b0\u1edbi d\u1ea1ng li\u1ec1u d\u00f9ng kh\u00f4ng \u0111\u1ed5i qua n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c l\u00e0 kho\u1ea3ng 2 &#8211; 6 gi\u1edd. M\u1ed9t ph\u1ea7n nh\u1ecf metformin hydrochloride ti\u1ebft \u0111\u01b0\u1ee3c qua s\u1eefa m\u1eb9<\/td>\n<td style=\"width: 50%;\">H\u1ea5p thu: Dapagliflozin h\u1ea5p thu t\u1ed1t v\u00e0 nhanh sau khi u\u1ed1ng. N\u1ed3ng \u0111\u1ed9 dapagliflozin t\u1ed1i \u0111a trong huy\u1ebft t\u01b0\u01a1ng (Cmax) th\u01b0\u1eddng \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00f2ng 2 gi\u1edd sau khi u\u1ed1ng thu\u1ed1c l\u00fac \u0111\u00f3i<\/p>\n<p>Ph\u00e2n b\u1ed1: Dapagliflozin li\u00ean k\u1ebft v\u1edbi protein kho\u1ea3ng 91%. S\u1ef1 g\u1eafn k\u1ebft v\u1edbi protein kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng trong c\u00e1c t\u00ecnh tr\u1ea1ng b\u1ec7nh kh\u00e1c nhau (v\u00ed d\u1ee5 nh\u01b0 suy th\u1eadn ho\u1eb7c gan). Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 trung b\u00ecnh \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh c\u1ee7a dapagliflozin l\u00e0 118 l\u00edt.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Dapagliflozin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a m\u1ea1nh, ch\u1ee7 y\u1ebfu th\u00e0nh dapagliflozin 3-O-glucuronid l\u00e0 m\u1ed9t ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh<\/p>\n<p>Th\u1ea3i tr\u1eeb: N\u1eeda \u0111\u1eddi th\u1ea3i tr\u1eeb trung b\u00ecnh (t1\/2) c\u1ee7a dapagliflozin \u1edf ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh l\u00e0 12,9 gi\u1edd sau khi u\u1ed1ng m\u1ed9t li\u1ec1u dapagliflozin 10 mg<\/p>\n<p>Sau khi d\u00f9ng [C]-dapagliflozin 50 mg, 96% \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y, bao g\u1ed3m 75% trong n\u01b0\u1edbc ti\u1ec3u v\u00e0 21% trong ph\u00e2n. Trong ph\u00e2n, kho\u1ea3ng 15% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c kh\u00f4ng bi\u1ebfn \u0111\u1ed5i.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Xigduo XR 10mg\/1000mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n<p>Thu\u1ed1c Xigduo XR 10mg\/1000mg \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p c\u00f9ng v\u1edbi ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang v\u00e0 t\u1eadp luy\u1ec7n \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng m\u00e1u c\u1ee7a ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh b\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng typ 2.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Metformin v\u1eabn kh\u00f4ng ki\u1ec3m so\u00e1t t\u1ed1t \u0111\u01b0\u1eddng huy\u1ebft \u1edf li\u1ec1u t\u1ed1i \u0111a.<\/p>\n<p>K\u1ebft h\u1ee3p v\u1edbi thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng kh\u00e1c n\u1ebfu ng\u01b0\u1eddi b\u1ec7nh ch\u01b0a ki\u1ec3m so\u00e1t t\u1ed1t \u0111\u01b0\u1eddng huy\u1ebft b\u1eb1ng \u0111\u01a1n tr\u1ecb li\u1ec7u.<\/p>\n<h2><span style=\"font-weight: 400;\">Li\u1ec1u d\u00f9ng &#8211; c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Xigduo XR 10mg\/1000mg<\/span><\/h2>\n<h3>C\u00e1ch d\u00f9ng thu\u1ed1c Xigduo XR 10mg\/1000mg<\/h3>\n<p><span style=\"font-size: 14.4px;\">Th\u01b0\u1eddng \u0111\u01b0\u1ee3c u\u1ed1ng v\u00e0o bu\u1ed5i s\u00e1ng v\u00e0 u\u1ed1ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n. Khi u\u1ed1ng, ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n u\u1ed1ng c\u1ea3 vi\u00ean thu\u1ed1c c\u00f2n nguy\u00ean v\u1eb9n, kh\u00f4ng nhai hay b\u1ebb vi\u00ean..<\/span><\/p>\n<h3>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Xigduo XR 10mg\/1000mg<\/h3>\n<p>Ng\u01b0\u1eddi b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Xigduo XR 10mg\/1000mg c\u1ea7n s\u1eed d\u1ee5ng li\u1ec1u ph\u00f9 h\u1ee3p, c\u0103n c\u1ee9 v\u00e0o li\u1ec7u tr\u00ecnh m\u00e0 ng\u01b0\u1eddi b\u1ec7nh \u0111ang \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh s\u1eed d\u1ee5ng m\u1ed7i l\u1ea7n 1 vi\u00ean, m\u1ed7i ng\u00e0y d\u00f9ng m\u1ed9t l\u1ea7n v\u00e0o bu\u1ed5i s\u00e1ng, \u0111i\u1ec1u ch\u1ec9nh t\u0103ng li\u1ec1u t\u1eeb t\u1eeb \u0111\u1ec3 tr\u00e1nh t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Metformin tr\u00ean d\u1ea1 d\u00e0y-ru\u1ed9t.<\/p>\n<p>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Xigduo XR 10mg\/1000mg c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a v\u00e0o \u0111\u00e1p \u1ee9ng v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p nh\u01b0ng t\u1ed1i \u0111a m\u1ed7i ng\u00e0y ch\u1ec9 d\u00f9ng 10 mg Dapagliflozin v\u00e0 2000 mg Metformin HCl.<\/p>\n<p>Tr\u01b0\u1eddng h\u1ee3p ng\u01b0\u1eddi b\u1ec7nh \u0111ang d\u00f9ng Metformin XR gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i v\u00e0o bu\u1ed5i t\u1ed1i, c\u1ea7n b\u1ecf li\u1ec1u cu\u1ed1i c\u00f9ng tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Xigduo XR 10mg\/1000mg.<\/p>\n<h2><span style=\"font-weight: 400;\">Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Xigduo XR 10mg\/1000mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n<p>Ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi Metformin, Dapagliflozin ho\u1eb7c b\u1ea5t k\u00ec th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c n\u00e0o trong thu\u1ed1c.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh nhi\u1ec5m toan chuy\u1ec3n h\u00f3a c\u1ea5p, ti\u1ec1n h\u00f4n m\u00ea \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh b\u1ecb thay \u0111\u1ed5i ch\u1ee9c n\u0103ng th\u1eadn do m\u1ea5t n\u01b0\u1edbc, s\u1ed1c ho\u1eb7c nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng, ho\u1eb7c ng\u01b0\u1eddi b\u1ecb suy th\u1eadn v\u1edbi m\u1ee9c l\u1ecdc c\u1ea7u th\u1eadn d\u01b0\u1edbi 60mL\/ph\u00fat.<\/p>\n<p>Kh\u00f4ng d\u00f9ng v\u1edbi ng\u01b0\u1eddi b\u1ec7nh suy tim, nh\u1ed3i m\u00e1u c\u01a1 tim, suy h\u00f4 h\u1ea5p g\u00e2y thi\u1ebfu oxy m\u00f4, ng\u01b0\u1eddi b\u1ec7nh suy gan, nghi\u1ec7n r\u01b0\u1ee3u ho\u1eb7c ng\u1ed9 \u0111\u1ed9c r\u01b0\u1ee3u c\u1ea5p.<\/p>\n<h2><span style=\"font-weight: 400;\">L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Xigduo XR 10mg\/1000mg<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Th\u1eadn tr\u1ecdng<\/span><\/h3>\n<p><em>Nhi\u1ec5m toan acid<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 c\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m toan lactic do metformin \u0111\u01b0\u1ee3c ghi nh\u1eadn trong qu\u00e1 tr\u00ecnh l\u01b0u h\u00e0nh thu\u1ed1c, bao g\u1ed3m c\u00e1c ca t\u1eed vong. Nh\u1eefng tr\u01b0\u1eddng h\u1ee3p n\u00e0y c\u00f3 m\u1ed9t kh\u1edfi ph\u00e1t nh\u1eb9 nh\u00e0ng v\u00e0 k\u00e8m theo c\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00f4ng \u0111\u1eb7c hi\u1ec7u nh\u01b0 m\u1ec7t m\u1ecfi, \u0111au c\u01a1, \u0111au b\u1ee5ng, suy h\u00f4 h\u1ea5p, ho\u1eb7c t\u0103ng bu\u1ed3n ng\u1ee7. Tuy nhi\u00ean, h\u1ea1 th\u00e2n nhi\u1ec7t, h\u1ea1 huy\u1ebft \u00e1p v\u00e0 nh\u1ecbp tim ch\u1eadm \u0111\u00e3 x\u1ea3y ra v\u1edbi tri\u1ec7u ch\u1ee9ng nhi\u1ec5m toan n\u1eb7ng.<\/p>\n<p>Nhi\u1ec5m toan acid do metformin \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi n\u1ed3ng \u0111\u1ed9 lactat trong m\u00e1u t\u0103ng l\u00ean (&gt; 5 mmol\/l), nhi\u1ec5m toan v\u1edbi kho\u1ea3ng tr\u1ed1ng anion (kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng ceton ni\u1ec7u ho\u1eb7c ceton huy\u1ebft) v\u00e0 t\u0103ng t\u1ef7 l\u1ec7 lactat : pyruvat; n\u1ed3ng \u0111\u1ed9 metformin huy\u1ebft t\u01b0\u01a1ng th\u01b0\u1eddng &gt; 5 mcg\/ml. Metformin l\u00e0m gan ch\u1eadm h\u1ea5p thu lactat, t\u0103ng lactat trong m\u00e1u t\u1eeb \u0111\u00f3 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic, \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao.<\/p>\n<p>N\u1ebfu nghi ng\u1edd nhi\u1ec5m toan lactic do metformin, c\u1ea7n ngay l\u1eadp t\u1ee9c ti\u1ebfn h\u00e0nh c\u00e1c bi\u1ec7n ph\u00e1p y t\u1ebf h\u1ed7 tr\u1ee3 th\u00f4ng th\u01b0\u1eddng t\u1ea1i b\u1ec7nh vi\u1ec7n, c\u00f9ng v\u1edbi vi\u1ec7c ngay l\u1eadp t\u1ee9c ng\u01b0ng thu\u1ed1c Xigduo XR.<\/p>\n<p>\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Xigduo XR c\u00f3 ch\u1ea9n \u0111o\u00e1n ho\u1eb7c ch\u1eafc ch\u1eafn nghi ng\u1edd nhi\u1ec5m toan lactic, n\u00ean k\u1ecbp th\u1eddi l\u1ecdc m\u00e1u \u0111\u1ec3 c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng nhi\u1ec5m toan v\u00e0 lo\u1ea1i b\u1ecf metformin t\u00edch l\u0169y (metformin hydroclorid c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ea9m t\u00e1ch, v\u1edbi \u0111\u1ed9 thanh th\u1ea3i l\u00ean t\u1edbi 170 ml\/ph\u00fat trong \u0111i\u1ec1u ki\u1ec7n huy\u1ebft \u0111\u1ed9ng t\u1ed1t). Th\u1ea9m t\u00e1ch m\u00e1u th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn \u0111\u1ea3o ng\u01b0\u1ee3c c\u00e1c tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed3i ph\u1ee5c.<\/p>\n<p>H\u01b0\u1edbng d\u1eabn b\u1ec7nh nh\u00e2n v\u00e0 gia \u0111\u00ecnh c\u1ee7a h\u1ecd v\u1ec1 c\u00e1c d\u1ea5u hi\u1ec7u tri\u1ec7u ch\u1ee9ng nhi\u1ec5m toan lactic v\u00e0 n\u1ebfu x\u1ea3y ra c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y th\u00ec y\u00eau c\u1ea7u b\u1ec7nh nh\u00e2n ng\u01b0ng thu\u1ed1c v\u00e0 b\u00e1o c\u00e1o tri\u1ec7u ch\u1ee9ng v\u1edbi b\u00e1c s\u1ef9.<\/p>\n<p>\u0110\u1ed1i v\u1edbi m\u1ed7i y\u1ebfu t\u1ed1 nguy c\u01a1 \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 c\u00f3 th\u1ec3 x\u1ea3y ra nhi\u1ec5m toan lactic do metformin, khuy\u1ebfn c\u00e1o gi\u1ea3m y\u1ebfu t\u1ed1 nguy c\u01a1 v\u00e0 ki\u1ec3m so\u00e1t t\u00ecnh tr\u1ea1ng nhi\u1ec5m toan lactic do metformin nh\u01b0 sau:<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy th\u1eadn<\/em><\/p>\n<p>C\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m toan lactic do metformin ch\u1ee7 y\u1ebfu x\u1ea3y ra \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng. Nguy c\u01a1 t\u00edch l\u0169y metformin v\u00e0 nhi\u1ec5m toan lactic do metformin t\u0103ng l\u00ean c\u00f9ng v\u1edbi m\u1ee9c \u0111\u1ed9 suy th\u1eadn v\u00ec metformin \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua th\u1eadn. C\u00e1c khuy\u1ebfn c\u00e1o l\u00e2m s\u00e0ng d\u1ef1a tr\u00ean ch\u1ee9c n\u0103ng th\u1eadn c\u1ee7a b\u1ec7nh nh\u00e2n bao g\u1ed3m<\/p>\n<ul>\n<li>Tr\u01b0\u1edbc khi kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi Xigduo XR, \u0111o \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn \u01b0\u1edbc t\u00ednh (eGFR).<\/li>\n<li>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng thu\u1ed1c Xigduo XR \u1edf b\u1ec7nh nh\u00e2n c\u00f3 eGFR &lt; 60 ml\/ph\u00fat\/1,73m2.<\/li>\n<li>Ti\u1ebfn h\u00e0nh \u0111o \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn \u01b0\u1edbc t\u00ednh (eGFR) \u00edt nh\u1ea5t l\u00e0 m\u1ed9t l\u1ea7n m\u1ed7i n\u0103m \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng Xigduo XR. \u1ede b\u1ec7nh nh\u00e2n t\u0103ng nguy c\u01a1 ti\u1ebfn tri\u1ec3n suy th\u1eadn (v\u00ed d\u1ee5: B\u1ec7nh nh\u00e2n cao tu\u1ed5i), n\u00ean \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn th\u01b0\u1eddng xuy\u00ean h\u01a1n.<\/li>\n<\/ul>\n<p><em>T\u1ed5n th\u01b0\u01a1ng th\u1eadn c\u1ea5p t\u00ednh v\u00e0 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn<\/em><\/p>\n<p>Dapagliflozin g\u00e2y gi\u1ea3m th\u1ec3 t\u00edch n\u1ed9i m\u1ea1ch, v\u00e0 c\u00f3 th\u1ec3 g\u00e2y ra suy th\u1eadn. \u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o trong qu\u00e1 tr\u00ecnh l\u01b0u h\u00e0nh thu\u1ed1c v\u1ec1 t\u1ed5n th\u01b0\u01a1ng th\u1eadn c\u1ea5p t\u00ednh, m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u1ea7n ph\u1ea3i nh\u1eadp vi\u1ec7n v\u00e0 l\u1ecdc m\u00e1u, \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng dapagliflozin: M\u1ed9t s\u1ed1 b\u00e1o c\u00e1o li\u00ean quan \u0111\u1ebfn b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 65 tu\u1ed5i.<\/p>\n<p>Dapagliflozin l\u00e0m t\u0103ng creatinine huy\u1ebft thanh v\u00e0 l\u00e0m gi\u1ea3m eGFR. B\u1ec7nh nh\u00e2n cao tu\u1ed5i v\u00e0 b\u1ec7nh nh\u00e2n b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn c\u00f3 th\u1ec3 d\u1ec5 nh\u1ea1y c\u1ea3m v\u1edbi c\u00e1c thay \u0111\u1ed5i n\u00e0y h\u01a1n. C\u00e1c ph\u1ea3n \u1ee9ng ngo\u1ea1i \u00fd li\u00ean quan \u0111\u1ebfn ch\u1ee9c n\u0103ng th\u1eadn c\u00f3 th\u1ec3 x\u1ea3y ra sau khi b\u1eaft \u0111\u1ea7u s\u1eed d\u1ee5ng thu\u1ed1c Xigduo XR. N\u00ean \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c Xigduo XR v\u00e0 theo d\u00f5i \u0111\u1ecbnh k\u1ef3 sau \u0111\u00f3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng Xigduo XR \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 eGFR &lt; 60 ml\/ph\u00fat\/1,73m2.<\/p>\n<p><em>Nhi\u1ec5m khu\u1ea9n huy\u1ebft do nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u v\u00e0 vi\u00eam b\u1ec3 th\u1eadn<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o trong qu\u00e1 tr\u00ecnh l\u01b0u h\u00e0nh thu\u1ed1c v\u1ec1 b\u1ec7nh nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u nghi\u00eam tr\u1ecdng bao g\u1ed3m nhi\u1ec5m khu\u1ea9n huy\u1ebft do nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u v\u00e0 vi\u00eam b\u1ec3 th\u1eadn m\u00e0 c\u1ea7n ph\u1ea3i nh\u1eadp vi\u1ec7n \u0111i\u1ec1u tr\u1ecb \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf SGLT2, bao g\u1ed3m dapagliflozin. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c \u1ee9c ch\u1ebf SGLT2 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u. Ki\u1ec3m tra b\u1ec7nh nh\u00e2n v\u1ec1 c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u v\u00e0 ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi n\u1ebfu \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh.<\/p>\n<p><em>Nhi\u1ec5m n\u1ea5m da \u1edf c\u01a1 quan sinh d\u1ee5c<\/em><\/p>\n<p>Dapagliflozin l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m n\u1ea5m \u1edf c\u01a1 quan sinh d\u1ee5c. B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed nhi\u1ec5m n\u1ea5m sinh d\u1ee5c c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng ti\u1ebfn tri\u1ec3n nhi\u1ec5m n\u1ea5m sinh d\u1ee5c. N\u00ean theo d\u00f5i v\u00e0 \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p.<\/p>\n<p>T\u0103ng Cholesterol Lipoprotein t\u1ef7 tr\u1ecdng th\u1ea5p (LDL &#8211; C)<\/p>\n<p>Dapagliflozin l\u00e0m t\u0103ng LDL &#8211; C. Theo d\u00f5i LDL &#8211; C v\u00e0 \u0111i\u1ec1u tr\u1ecb theo m\u1ee9c \u0111\u1ed9 ch\u0103m s\u00f3c sau khi b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c Xigduo XR.<\/p>\n<p><em>Ung th\u01b0 b\u00e0ng quang<\/em><\/p>\n<p>Trong 22 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng, c\u00e1c tr\u01b0\u1eddng h\u1ee3p ung th\u01b0 b\u00e0ng quang m\u1edbi ch\u1ea9n \u0111o\u00e1n \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf 10\/6045 b\u1ec7nh nh\u00e2n (0,17%) \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi dapagliflozin v\u00e0 1\/3512 b\u1ec7nh nh\u00e2n (0,03%) \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi gi\u1ea3 d\u01b0\u1ee3c\/thu\u1ed1c \u0111\u1ed1i ch\u1ee9ng. Sau khi lo\u1ea1i tr\u1eeb c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 d\u00f9ng thu\u1ed1c nghi\u00ean c\u1ee9u \u00edt h\u01a1n m\u1ed9t n\u0103m t\u1ea1i th\u1eddi \u0111i\u1ec3m ch\u1ea9n \u0111o\u00e1n ung th\u01b0 b\u00e0ng quang, c\u00f3 4 tr\u01b0\u1eddng h\u1ee3p d\u00f9ng dapagliflozin v\u00e0 kh\u00f4ng c\u00f3 tr\u01b0\u1eddng h\u1ee3p d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c\/thu\u1ed1c \u0111\u1ed1i ch\u1ee9ng.<\/p>\n<p>C\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 ung th\u01b0 b\u00e0ng quang v\u00e0 ti\u1ec3u m\u00e1u (m\u1ed9t ch\u1ec9 th\u1ecb nghi ng\u1edd kh\u1ed1i u s\u1eb5n c\u00f3) \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 \u0111\u1ec1u gi\u1eefa c\u00e1c nh\u00f3m \u0111i\u1ec1u tr\u1ecb \u1edf th\u1eddi \u0111i\u1ec3m b\u1eaft \u0111\u1ea7u. C\u00f3 qu\u00e1 \u00edt tr\u01b0\u1eddng h\u1ee3p \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh xem s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c bi\u1ebfn c\u1ed1 n\u00e0y c\u00f3 li\u00ean quan \u0111\u1ebfn dapagliflozin hay kh\u00f4ng.<\/p>\n<h3><span style=\"font-weight: 400;\">T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\n<p>Nhi\u1ec5m tr\u00f9ng tr\u00ean da v\u00e0 b\u1ed9 ph\u1eadn sinh d\u1ee5c, vi\u00eam \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u.<\/p>\n<p>R\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a, h\u1ea1 \u0111\u01b0\u1eddng m\u00e1u \u0111\u1eb7c bi\u1ec7t n\u1ebfu d\u00f9ng c\u00f9ng v\u1edbi Insulin ho\u1eb7c SU.<\/p>\n<p>R\u1ed1i lo\u1ea1n th\u1ea7n kinh, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c.<\/p>\n<p>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a do d\u00f9ng Xigduo XR 10mg\/1000mg nh\u01b0 bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng, \u0103n kh\u00f4ng ngon mi\u1ec7ng.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u0169ng c\u00f3 th\u1ec3 g\u1eb7p m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n kh\u00e1c nh\u01b0 ph\u00e1t ban, \u0111au l\u01b0ng, ti\u1ec3u nhi\u1ec1u, r\u1ed1i lo\u1ea1n lipid m\u00e1u.<\/p>\n<h3><span style=\"font-weight: 400;\">T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n<p><em>X\u00e9t nghi\u1ec7m d\u01b0\u01a1ng t\u00ednh glucose trong n\u01b0\u1edbc ti\u1ec3u.<\/em><\/p>\n<p>Dapagliflozin: Theo d\u00f5i ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft b\u1eb1ng x\u00e9t nghi\u1ec7m glucose trong n\u01b0\u1edbc ti\u1ec3u kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o \u1edf b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c \u1ee9c ch\u1ebf k\u00eanh SGLT2, do thu\u1ed1c \u1ee9c ch\u1ebf k\u00eanh SGLT2 l\u00e0m t\u0103ng b\u00e0i ti\u1ebft glucose qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 d\u1eabn \u0111\u1ebfn x\u00e9t nghi\u1ec7m d\u01b0\u01a1ng t\u00ednh glucose trong n\u01b0\u1edbc ti\u1ec3u<\/p>\n<p><em>Can thi\u1ec7p k\u1ebft qu\u1ea3 x\u00e9t nghi\u00eam \u0111\u1ecbnh l\u01b0\u1ee3ng 1,5-anhydroglucitol (1,5-AG)<\/em><\/p>\n<p>Dapagliflozin: Theo d\u00f5i ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft b\u1eb1ng x\u00e9t nghi\u1ec7m \u0111\u1ecbnh l\u01b0\u1ee3ng 1,5-AG kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o v\u00ec ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ecbnh l\u01b0\u1ee3ng 1,5-AG kh\u00f4ng \u0111\u00e1ng tin c\u1eady trong \u0111\u00e1nh gi\u00e1 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf SGLT2. N\u00ean s\u1eed d\u1ee5ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p thay th\u00e9 kh\u00e1c \u0111\u1ec3 theo d\u00f5i ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<p><em>Thu\u1ed1c \u1ee9c ch\u1ebf enzym carbonic anhydrase<\/em><\/p>\n<p>Toiramat ho\u1eb7c c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf anhydrase cacbonic kh\u00e1c (v\u00ed d\u1ee5 zonisamid, acetazolamid ho\u1eb7c dichlophenamid) th\u01b0\u1eddng l\u00e0m gi\u1ea3m bicarbonat huy\u1ebft thanh v\u00e0 g\u00e2y ra kho\u1ea3ng tr\u1ed1ng kh\u00f4ng phai anion, nhi\u1ec5m toan t\u0103ng clorua huy\u1ebft. Vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c n\u00e0y v\u1edbi XIGDUO XR c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic. Xem x\u00e9t theo d\u00f5i th\u01b0\u1eddng xuy\u00ean h\u01a1n nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y<\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c h\u1ec7 th\u1ed1ng v\u1eadn chuy\u1ec3n \u1ed1ng th\u1eadn th\u00f4ng th\u01b0\u1eddng c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c th\u1ea3i tr\u1eeb metformin \u1edf th\u1eadn (v\u00ed d\u1ee5: k\u00eanh v\u1eadn chuy\u1ec3n cation h\u1eefu c\u01a1 2 [OCT2] \/ \u0111a thu\u1ed1c \/ v\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf \u0111\u1ed9c t\u1ed1 nh\u01b0 l\u00e0 ranolazin, vandetanib, dolutegravir v\u00e0 cimetidin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng ti\u1ebfp x\u00fac thu\u1ed1c to\u00e0n th\u00e2n v\u1edbi metformin v\u00e0 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic, c\u1ea7n c\u00e2n nh\u1eafc xem x\u00e9t c\u00e1c l\u1ee3i \u00edch v\u00e0 r\u1ee7i ro c\u1ee7a vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c n\u00e0y.<\/p>\n<p>Ch\u1ea5t c\u1ed3n \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a metformin tr\u00ean s\u1ef1 chuy\u1ec3n h\u00f3a lactat. Khuy\u1ebfn c\u00e1o b\u1ec7nh nh\u00e2n kh\u00f4ng u\u1ed1ng nhi\u1ec1u r\u01b0\u1ee3u trong khi d\u00f9ng thu\u1ed1c<\/p>\n<h3><span style=\"font-weight: 400;\">L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/span><\/h3>\n<p>Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u v\u1ec1 s\u1eed d\u1ee5ng Xigduo XR 10mg\/1000mg cho ph\u1ee5 n\u1eef mang thai v\u00e0 cho con b\u00fa do \u0111\u00f3 nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng.<\/p>\n<h3><span style=\"font-weight: 400;\">\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/span><\/h3>\n<p>Dapagliflozin ho\u1eb7c metformin kh\u00f4ng c\u00f3 ho\u1eb7c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. B\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c c\u1ea3nh b\u00e1o v\u1ec1 nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft khi d\u00f9ng thu\u1ed1c k\u1ebft h\u1ee3p v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft kh\u00e1c m\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 c\u00f3 nguy c\u01a1 g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n<h3><span style=\"font-weight: 400;\">Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n<p><em>Dapagliflozin<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 b\u00e1o c\u00e1o v\u1ec1 qu\u00e1 li\u1ec1u trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n l\u00e2m s\u00e0ng c\u1ee7a thu\u1ed1c dapagliflozin. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, h\u00e3y li\u00ean h\u1ec7 v\u1edbi \u0111\u01a1n v\u1ecb Ch\u1ed1ng \u0110\u1ed9c c\u1ee7a B\u1ec7nh vi\u1ec7n. Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 theo t\u00ecnh tr\u1ea1ng l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh nh\u00e2n c\u0169ng th\u00edch h\u1ee3p. Vi\u1ec7c lo\u1ea1i b\u1ecf dapagliflozin b\u1eb1ng l\u1ecdc m\u00e1u v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u.<\/p>\n<p><em>Metformin hydroclorid<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 x\u1ea3y ra qu\u00e1 li\u1ec1u metformin hydroclorid, bao g\u1ed3m ti\u00eau h\u00f3a li\u1ec1u l\u01b0\u1ee3ng &gt; 50 gram. H\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong kho\u1ea3ng 10% tr\u01b0\u1eddng h\u1ee3p, nh\u01b0ng kh\u00f4ng c\u00f3 thi\u1ebft l\u1eadp m\u1ed1i li\u00ean quan nh\u00e2n qu\u1ea3 v\u1edbi metformin hydroclorid. Nhi\u1ec5m toan lactic \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong kho\u1ea3ng 32% c\u00e1c tr\u01b0\u1eddng h\u1ee3p d\u00f9ng qu\u00e1 li\u1ec1u metformin [xem ph\u1ea7n L\u01b0u \u00dd \u0110\u1eb7c Bi\u1ec7t v\u00e0 Th\u1eadn Tr\u1ecdng Khi S\u1eed D\u1ee5ng]. Metformin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ea9m t\u00e1ch v\u1edbi \u0111\u1ed9 thanh th\u1ea3i l\u00ean \u0111\u1ebfn 170 ml\/ph\u00fat trong \u0111i\u1ec1u ki\u1ec7n huy\u1ebft \u0111\u1ed9ng t\u1ed1t. Do \u0111\u00f3, l\u1ecdc m\u00e1u c\u00f3 th\u1ec3 h\u1eefu \u00edch \u0111\u1ec3 lo\u1ea1i b\u1ecf c\u00e1c thu\u1ed1c t\u00edch l\u0169y t\u1eeb nh\u1eefng b\u1ec7nh nh\u00e2n m\u00e0 nghi ng\u1edd l\u00e0 qu\u00e1 li\u1ec1u.<\/p>\n<h3><span style=\"font-weight: 400;\">B\u1ea3o qu\u1ea3n<\/span><\/h3>\n<p>B\u1ea3o qu\u1ea3n d\u01b0\u1edbi 30\u00b0C.<\/p>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Xigduo XR 10mg\/1000mg gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Thu\u1ed1c Xigduo XR 10mg\/1000mg hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, <strong>gi\u00e1 thu\u1ed1c Xigduo XR 10mg\/1000mg <\/strong>c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c thu\u1ed1c (s\u1ea3n ph\u1ea9m) h\u1ea1 glucose huy\u1ebft d\u1ea1ng ph\u1ed1i h\u1ee3p kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c nh\u01b0:\u00a0<\/span><\/p>\n<ol>\n<li>\u00a0<a href=\"https:\/\/hmm88i.com\/drug\/komboglyze-xr\/\">Thu\u1ed1c Komboglyze XR<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Bristol Myers Squibb, Ph\u00e1p, l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Saxagliptin v\u1edbi h\u00e0m l\u01b0\u1ee3ng 5 mg v\u00e0 Metformin Hydrochloride v\u1edbi h\u00e0m l\u01b0\u1ee3ng 1000 mg trong 1 vi\u00ean n\u00e9n bao phim. M\u1ed7i h\u1ed9p thu\u1ed1c Komboglyze XR c\u00f3 4 v\u1ec9, m\u1ed7i v\u1ec9 c\u00f3 7 vi\u00ean n\u00e9n bao phim c\u00f3 gi\u00e1 l\u00e0 630.000 \u0111\u1ed3ng.<\/li>\n<li><a href=\"https:\/\/hmm88i.com\/drug\/melanov-m\/\"> Thu\u1ed1c Melanov-M<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty Micro Labs Limited, \u2013 \u1ea4N \u0110\u1ed8, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-20575-17, l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng tu\u00fdp 2 \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh, c\u00f3 th\u00e0nh ph\u1ea7n ch\u00ednh g\u1ed3m Gliclazide v\u1edbi h\u00e0m l\u01b0\u1ee3ng 80 mg v\u00e0 Metformin hydrochloride v\u1edbi h\u00e0m l\u01b0\u1ee3ng 500 mg. M\u1ed7i h\u1ed9p thu\u1ed1c Melanov-M g\u1ed3m 10 v\u1ec9, m\u1ed7i v\u1ec9 ch\u1ee9a 10 vi\u00ean c\u00f3 gi\u00e1 l\u00e0 620000 \u0111\u1ed3ng.<\/li>\n<\/ol>\n<h2><span style=\"font-weight: 400;\">T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Xigduo XR 10mg\/1000mg?<\/span><\/h2>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 54.2394%; text-align: center;\">\u01afu \u0111i\u1ec3m<\/td>\n<td style=\"width: 45.7606%; text-align: center;\">Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 54.2394%;\">Xigduo XR 10mg\/1000mg \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n bao phim gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i n\u00ean thu\u1ed1c s\u1ebd \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t su\u1ed1t 12 ho\u1eb7c 24 gi\u1edd gi\u00fap gi\u1ea3m s\u1ed1 l\u1ea7n d\u00f9ng thu\u1ed1c trong ng\u00e0y, gi\u00fap ng\u01b0\u1eddi d\u00f9ng d\u1ec5 tu\u00e2n th\u1ee7 h\u01a1n.<\/p>\n<p>Metformin l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i thu\u1ed1c h\u1ea1 glucose \u0111\u01b0\u1eddng u\u1ed1ng ph\u1ed5 bi\u1ebfn nh\u1ea5t, \u0111\u01b0\u1ee3c coi l\u00e0 li\u1ec7u ph\u00e1p ban \u0111\u1ea7u t\u1ed1i \u01b0u cho b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00fdp 2.<\/p>\n<p>N\u00f3 hi\u1ec7n \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7u tay trong nhi\u1ec1u h\u01b0\u1edbng d\u1eabn kh\u00e1c nhau, bao g\u1ed3m c\u1ea3 h\u01b0\u1edbng d\u1eabn c\u1ee7a EASD v\u00e0 ADA.<\/p>\n<p>Metformin l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7u tay cho b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00fdp 2 v\u00e0 l\u00e0 lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n ph\u1ed5 bi\u1ebfn nh\u1ea5t cho t\u00ecnh tr\u1ea1ng n\u00e0y tr\u00ean to\u00e0n th\u1ebf gi\u1edbi, \u0111\u01a1n \u0111\u1ed9c ho\u1eb7c k\u1ebft h\u1ee3p v\u1edbi insulin ho\u1eb7c c\u00e1c li\u1ec7u ph\u00e1p h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft kh\u00e1c.<\/p>\n<p>Metformin l\u00e0 m\u1ed9t biguanide, m\u1ed9t lo\u1ea1i thu\u1ed1c c\u00f3 ngu\u1ed3n g\u1ed1c th\u1ea3o d\u01b0\u1ee3c \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng t\u1eeb nh\u1eefng n\u0103m 1950<\/p>\n<p>Dapagliflozin l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf \u0111\u1ed3ng v\u1eadn chuy\u1ec3n natri-glucose-2 m\u1ea1nh, c\u00f3 th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c v\u00e0 ch\u1ecdn l\u1ecdc \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh tr\u00ean to\u00e0n th\u1ebf gi\u1edbi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2 (T2D).<\/p>\n<p>\u1ede Ch\u00e2u \u00c2u, dapagliflozin \u0111\u01b0\u1eddng u\u1ed1ng 1 l\u1ea7n\/ng\u00e0y \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng d\u01b0\u1edbi d\u1ea1ng \u0111\u01a1n tr\u1ecb li\u1ec7u ho\u1eb7c<\/p>\n<p>ph\u1ed1i h\u1ee3p b\u1ed5 sung (v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft kh\u00e1c, bao g\u1ed3m c\u1ea3 insulin) cho T2D khi ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang v\u00e0 t\u1eadp th\u1ec3 d\u1ee5c \u0111\u01a1n thu\u1ea7n kh\u00f4ng \u0111\u00e1p \u1ee9ng \u0111\u01b0\u1ee3c. cung c\u1ea5p \u0111\u1ea7y \u0111\u1ee7 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft<\/td>\n<td style=\"width: 45.7606%;\">Gi\u00e1 th\u00e0nh h\u01a1i cao<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">T\u00e1c gi\u1ea3 Elizabeth Sanchez-Rangel 1, Silvio E Inzucchi (Ng\u00e0y \u0111\u0103ng: Th\u00e1ng 9 n\u0103m 2017). <em>Metformin: clinical use in type 2 diabetes<\/em>. Truy c\u1eadp ng\u00e0y 19 th\u00e1ng 11 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28770321\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28770321\/<\/a><\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">T\u00e1c gi\u1ea3 Sohita Dhillon (Ng\u00e0y \u0111\u0103ng: Th\u00e1ng 7 n\u0103m 2019). <em>Dapagliflozin: A Review in Type 2 Diabetes<\/em>. Truy c\u1eadp ng\u00e0y 19 th\u00e1ng 11 n\u0103m 2023, t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31236801\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31236801\/<\/a><\/span><\/li>\n<li>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c Xigduo XR 10mg\/1000mg do nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p, t\u1ea3i b\u1ea3n PDF <a href=\"https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2023\/11\/Huong-dan-su-dung-thuoc-xigduo-1000-10-vnras.pdf\">t\u1ea1i \u0111\u00e2y<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Xigduo XR 10mg\/1000mg tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng tu\u00fdp 2 (4 v\u1ec9 x 7 vi\u00ean), ch\u1ee9a Metformin v\u00e0 Dapagliflozin<\/p>\n","protected":false},"author":490,"featured_media":58273,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-58261","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product\/58261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/comments?post=58261"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media\/58273"}],"wp:attachment":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media?parent=58261"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_cat?post=58261"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_tag?post=58261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}