{"id":56776,"date":"2023-11-14T05:29:09","date_gmt":"2023-11-13T22:29:09","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&#038;p=56776"},"modified":"2025-07-24T13:59:37","modified_gmt":"2025-07-24T06:59:37","slug":"xalvobin-500mg-film-coated-tablet","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/xalvobin-500mg-film-coated-tablet\/","title":{"rendered":"Xalvobin 500mg film-coated tablet"},"content":{"rendered":"<p><b>Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <a href=\"https:\/\/hmm88i.com\/drug\/xalvobin-500mg-film-coated-tablet\/\">Xalvobin 500mg film-coated tablet<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m Remedica Ltd, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-20931-18.<\/b><\/p>\n<h2><span style=\"font-weight: 400;\">Xalvobin 500mg l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n<p><b>Thu\u1ed1c Xalvobin 500mg<\/b><span style=\"font-weight: 400;\"> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n tromg m\u1ed7i vi\u00ean n\u00e9n l\u00e0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Capecitabine c\u00f3 h\u00e0m l\u01b0\u1ee3ng 500mg<\/span><\/p>\n<p><span style=\"font-weight: 400;\">T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/span><\/p>\n<p><span style=\"font-weight: 400;\">D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Tr\u00ecnh b\u00e0y<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">S\u0110K: VN-20931-18<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 12 v\u1ec9 x 10 vi\u00ean.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Xu\u1ea5t x\u1ee9: C\u1ed9ng h\u00f2a S\u00edp<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Xalvobin 500mg film-coated tablet<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\n<p><b>Capecitabine <\/b><span style=\"font-weight: 400;\">l\u00e0 m\u1ed9t este carbamate l\u00e0 cytidine trong \u0111\u00f3 hydro \u1edf v\u1ecb tr\u00ed 5 \u0111\u01b0\u1ee3c thay th\u1ebf b\u1eb1ng flo v\u00e0 trong \u0111\u00f3 nh\u00f3m amino g\u1eafn v\u00e0o v\u1ecb tr\u00ed 4 \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh d\u1eabn xu\u1ea5t N-(penyloxy)carbonyl c\u1ee7a n\u00f3. Capecitabine l\u00e0 m\u1ed9t t\u00e1c nh\u00e2n h\u00f3a tr\u1ecb li\u1ec7u d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa v\u00e0 ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng di c\u0103n. Capecitabine l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t, \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1eb1ng enzym th\u00e0nh fluorouracil (ch\u1ea5t ch\u1ed1ng chuy\u1ec3n h\u00f3a) trong kh\u1ed1i u, t\u1ea1i \u0111\u00e2y n\u00f3 \u1ee9c ch\u1ebf s\u1ef1 t\u1ed5ng h\u1ee3p DNA v\u00e0 l\u00e0m ch\u1eadm s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u00f4 kh\u1ed1i u.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Capecitabine l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t ch\u1ecdn l\u1ecdc kh\u1ed1i u th\u00e0nh ph\u1ea7n g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o c\u1ee7a n\u00f3, fluorouracil , b\u1edfi thymidine phosphorylase, m\u1ed9t lo\u1ea1i enzyme \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf n\u1ed3ng \u0111\u1ed9 cao h\u01a1n trong nhi\u1ec1u kh\u1ed1i u so v\u1edbi c\u00e1c m\u00f4 ho\u1eb7c huy\u1ebft t\u01b0\u01a1ng b\u00ecnh th\u01b0\u1eddng. Fluorouracil \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ti\u1ebfp th\u00e0nh hai ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh l\u00e0 5-fluoro-2&#8242;-deoxyuridine 5&#8242;-monophosphate ( FdUMP ) v\u00e0 5-fluorouridine triphosphate ( FUTP ), trong t\u1ebf b\u00e0o kh\u1ed1i u v\u00e0 t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nh\u1eefng ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y g\u00e2y t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o theo hai c\u01a1 ch\u1ebf kh\u00e1c nhau:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u0110\u1ea7u ti\u00ean, FdUMP v\u00e0 \u0111\u1ed3ng y\u1ebfu t\u1ed1 folate, N5-10-methylenetetrahydrofolate, li\u00ean k\u1ebft v\u1edbi thymidylate synthase (TS) \u0111\u1ec3 t\u1ea1o th\u00e0nh ph\u1ee9c h\u1ee3p ternary li\u00ean k\u1ebft c\u1ed9ng h\u00f3a tr\u1ecb. Li\u00ean k\u1ebft n\u00e0y \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh thymidylate t\u1eeb 2&#8242;-deaxyuridylate. Thymidylate l\u00e0 ti\u1ec1n ch\u1ea5t c\u1ea7n thi\u1ebft c\u1ee7a thymidine triphosphate , r\u1ea5t c\u1ea7n thi\u1ebft cho qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p DNA, do \u0111\u00f3 s\u1ef1 thi\u1ebfu h\u1ee5t h\u1ee3p ch\u1ea5t n\u00e0y c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e2n chia t\u1ebf b\u00e0o.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Th\u1ee9 hai, c\u00e1c enzyme phi\u00ean m\u00e3 h\u1ea1t nh\u00e2n c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p nh\u1ea7m FUTP thay cho uridine triphosphate ( UTP ) trong qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p RNA. L\u1ed7i trao \u0111\u1ed5i ch\u1ea5t n\u00e0y c\u00f3 th\u1ec3 c\u1ea3n tr\u1edf qu\u00e1 tr\u00ecnh x\u1eed l\u00fd RNA v\u00e0 t\u1ed5ng h\u1ee3p protein<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">H\u1ea5p thu: Capecitabine d\u1ec5 d\u00e0ng h\u1ea5p thu qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, kho\u1ea3ng tr\u00ean 70% li\u1ec1u u\u1ed1ng c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c h\u1ea5p thu. M\u1eb7c d\u00f9 c\u00e1c nghi\u00ean c\u1ee9u in vitro \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng capecitabine kh\u00f4ng \u1ed5n \u0111\u1ecbnh trong \u0111i\u1ec1u ki\u1ec7n c\u00f3 t\u00ednh axit cao, thu\u1ed1c d\u01b0\u1eddng nh\u01b0 \u0111\u01b0\u1ee3c h\u1ea5p thu nguy\u00ean v\u1eb9n ngay l\u1eadp t\u1ee9c khi h\u00f2a tan m\u00e0 kh\u00f4ng b\u1ecb ph\u00e2n h\u1ee7y th\u1ee9 c\u1ea5p do pH axit c\u1ee7a d\u1ea1 d\u00e0y.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chuy\u1ec3n h\u00f3a: Capecitabine, m\u1ed9t ti\u1ec1n ch\u1ea5t ch\u1ed1ng ung th\u01b0, \u0111\u01b0\u1ee3c cho l\u00e0 \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a sinh h\u1ecdc th\u00e0nh 5-fluorouracil ( 5-FU ) ho\u1ea1t \u0111\u1ed9ng nh\u1edd ba enzyme. Sau khi u\u1ed1ng, capecitabine l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh 5&#8242;-deoxy-5-fluorocytidine (5&#8242;-DFCR) b\u1edfi carboxylesterase (CES), sau \u0111\u00f3 5&#8242;-DFCR \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh 5&#8242;-deoxy-5-fluorouridine ( 5&#8242;-DFUR ) b\u1edfi cytidine deaminase. 5&#8242;-DFUR \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t th\u00e0nh 5-FU b\u1edfi thymidine phosphorylase. M\u1eb7c d\u00f9 ho\u1ea1t t\u00ednh cao c\u1ee7a c\u00e1c enzyme chuy\u1ec3n h\u00f3a thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n \u1edf gan ng\u01b0\u1eddi nh\u01b0ng s\u1ef1 li\u00ean quan c\u1ee7a gan trong qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a capecitabine v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u \u0111\u1ea7y \u0111\u1ee7.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Th\u1ea3i tr\u1eeb: Capecitabine v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u 95,5% li\u1ec1u capecitabine d\u00f9ng \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong n\u01b0\u1edbc ti\u1ec3u. S\u1ef1 b\u00e0i ti\u1ebft qua ph\u00e2n l\u00e0 t\u1ed1i thi\u1ec3u (2,6%). Ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u l\u00e0 FBAL, chi\u1ebfm 57% li\u1ec1u d\u00f9ng. Kho\u1ea3ng 3% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c kh\u00f4ng \u0111\u1ed5i.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Xalvobin 500mg film-coated tablet \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Xalvobin 500mg \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">H\u1ed7 tr\u1ee3 b\u1ec7nh nh\u00e2n sau ph\u1eabu thu\u1eadt ung th\u01b0 \u0111\u1ea1i tr\u00e0ng giai \u0111o\u1ea1n III.<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u0110i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng di c\u0103n<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Ph\u1ed1i h\u1ee3p c\u00f9ng v\u1edbi h\u1ee3p ch\u1ea5t platin trong ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb b\u01b0\u1edbc 1 cho nh\u1eefng b\u1ec7nh nh\u00e2n ung th\u01b0 d\u1ea1 d\u00e0y ti\u1ebfn tri\u1ec3n.<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Ph\u1ed1i h\u1ee3p c\u00f9ng v\u1edbi docetaxel trong ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa ti\u1ebfn tri\u1ec3n t\u1ea1i ch\u1ed7 ho\u1eb7c di c\u0103n sau khi \u0111i\u1ec1u tr\u1ecb h\u00f3a tr\u1ecb li\u1ec7u \u0111\u1ed9c t\u1ebf b\u00e0o kh\u00f4ng hi\u1ec7u qu\u1ea3. Li\u1ec7u ph\u00e1p tr\u01b0\u1edbc bao g\u1ed3m anthracycline.<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u0110\u01a1n tr\u1ecb li\u1ec7u cho b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa ti\u1ebfn tri\u1ec3n t\u1ea1i ch\u1ed7 ho\u1eb7c di c\u0103n sau khi \u0111i\u1ec1u tr\u1ecb v\u1edbi anthracycline v\u00e0 taxan kh\u00f4ng hi\u1ec7u qu\u1ea3 ho\u1eb7c nh\u1eefng ung th\u01b0 kh\u00e1c kh\u00f4ng c\u00f3 ch\u1ec9 \u0111\u1ecbnh d\u00f9ng anthracycline.<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Xalvobin 500mg film-coated tablet<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">C\u00e1ch d\u00f9ng<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Li\u1ec1u d\u00f9ng c\u1ee5 th\u1ec3 ph\u1ea3i \u0111\u01b0\u1ee3c b\u00e1c s\u0129 c\u00f3 chuy\u00ean m\u00f4n h\u01b0\u1edbng d\u1eabn v\u00e0 ch\u1ec9 \u0111\u1ecbnh d\u00f9ng.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">U\u1ed1ng thu\u1ed1c sau khi \u0103n kho\u1ea3ng 30 ph\u00fat v\u1edbi n\u01b0\u1edbc.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ng\u01b0ng s\u1eed d\u1ee5ng khi b\u1ec7nh ti\u1ebfn tri\u1ec3n ho\u1eb7c nh\u1eefng ph\u1ea3n \u1ee9ng \u0111\u1ed9c t\u00ednh kh\u00f4ng ch\u1ecbu \u0111\u01b0\u1ee3c.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Li\u1ec1u d\u00f9ng<\/span><\/h3>\n<p><i><span style=\"font-weight: 400;\">\u0110\u01a1n tr\u1ecb li\u1ec7u<\/span><\/i><\/p>\n<p><i><span style=\"font-weight: 400;\">Ung th\u01b0 \u0111\u1ea1i tr\u00e0ng, ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng v\u00e0 ung th\u01b0 v\u00fa<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 1250mg\/m2, 2 l\u1ea7n m\u1ed7i ng\u00e0y (s\u00e1ng, t\u1ed1i t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi t\u1ed5ng li\u1ec1u 2500mg\/m2 m\u1ed7i ng\u00e0y). trong 14 ng\u00e0y, sau \u0111\u00f3 d\u1eebng 7 ng\u00e0y.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Li\u1ec1u h\u1ed7 tr\u1ee3 cho b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u1ea1i tr\u00e0ng giai \u0111o\u1ea1n III \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng trong 6 th\u00e1ng.<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">\u0110i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p<\/span><\/i><\/p>\n<p><i><span style=\"font-weight: 400;\">Ung th\u01b0 \u0111\u1ecba tr\u00e0ng, ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng v\u00e0 ung th\u01b0 d\u1ea1 d\u00e0y<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">Li\u1ec1u kh\u1edfi \u0111\u1ea7u: N\u00ean gi\u1ea3m li\u1ec1u t\u1edbi 800-1000mg\/m2, 2 l\u1ea7n m\u1ed7i ng\u00e0y trong 14 ng\u00e0y, sau \u0111\u00f3 d\u1eebng 7 ng\u00e0y, ho\u1eb7c 625 mg\/m2, 2 l\u1ea7n m\u1ed7i ng\u00e0y khi d\u00f9ng li\u00ean t\u1ee5c. C\u00e1c thu\u1ed1c sinh ph\u1ea9m khi \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p v\u1edbi capecitabine kh\u00f4ng \u1ea3nh h\u01b0\u1edfng t\u1edbi li\u1ec1u kh\u1edfi \u0111\u1ea7u c\u1ee7a thu\u1ed1c.<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">\u0110\u1ed9c t\u00ednh do s\u1eed d\u1ee5ng thu\u1ed1c c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t b\u1eb1ng vi\u1ec7c \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng ho\u1eb7c c\u00f3 th\u1ec3 thay \u0111\u1ed5i li\u1ec1u capecitabin (ng\u01b0ng \u0111i\u1ec1u tr\u1ecb ho\u1eb7c gi\u1ea3m li\u1ec1u), v\u00e0 kh\u00f4ng n\u00ean t\u0103ng sau khi \u0111\u00e3 gi\u1ea3m li\u1ec1u.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">S\u1ef1 thay \u0111\u1ed5i li\u1ec1u capecitabin \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o do xu\u1ea5t hi\u1ec7n \u0111\u1ed9c t\u00ednh.<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td>M\u1ee9c \u0111\u1ed9 \u0111\u1ed9c t\u00ednh<\/td>\n<td>Thay \u0111\u1ed5i li\u1ec1u trong 1 li\u1ec7u tr\u00ecnh \u0111i\u1ec1u tr\u1ecb<\/td>\n<td>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u cho li\u1ec7u tr\u00ecnh ti\u1ebfp theo (% c\u1ee7a li\u1ec1u kh\u1edfi \u0111\u1ea7u)<\/td>\n<\/tr>\n<tr>\n<td>\u0110\u1ed9 1<\/td>\n<td>Duy tr\u00ec li\u1ec1u<\/td>\n<td>Duy tr\u00ec li\u1ec1u<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\">\u0110\u1ed9 2<\/td>\n<\/tr>\n<tr>\n<td>Xu\u1ea5t hi\u1ec7n l\u1ea7n \u0111\u1ea7u<\/td>\n<td rowspan=\"3\">Ng\u1eebng cho \u0111\u1ebfn khi h\u1ed3i ph\u1ee5c v\u1ec1 m\u1ee9c \u0111\u1ed9 0-1<\/td>\n<td>100%<\/td>\n<\/tr>\n<tr>\n<td>Xu\u1ea5t hi\u1ec7n l\u1ea7n 2<\/td>\n<td>75%<\/td>\n<\/tr>\n<tr>\n<td>Xu\u1ea5t hi\u1ec7n l\u1ea7n 3<\/td>\n<td>50%<\/td>\n<\/tr>\n<tr>\n<td>Xu\u1ea5t hi\u1ec7n l\u1ea7n 4<\/td>\n<td colspan=\"2\">Ng\u01b0ng \u0111i\u1ec1u tr\u1ecb v\u0129nh vi\u1ec5n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\">\u0110\u1ed9 3<\/td>\n<\/tr>\n<tr>\n<td>Xu\u1ea5t hi\u1ec7n l\u1ea7n \u0111\u1ea7u<\/td>\n<td rowspan=\"2\">Ng\u1eebng cho \u0111\u1ebfn khi h\u1ed3i ph\u1ee5c v\u1ec1 m\u1ee9c \u0111\u1ed9 0-1<\/td>\n<td>75%<\/td>\n<\/tr>\n<tr>\n<td>Xu\u1ea5t hi\u1ec7n l\u1ea7n 2<\/td>\n<td>50%<\/td>\n<\/tr>\n<tr>\n<td>Xu\u1ea5t hi\u1ec7n l\u1ea7n 3<\/td>\n<td colspan=\"2\">Ng\u01b0ng \u0111i\u1ec1u tr\u1ecb v\u0129nh vi\u1ec5n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\">\u0110\u1ed9 4<\/td>\n<\/tr>\n<tr>\n<td>Xu\u1ea5t hi\u1ec7n l\u1ea7n \u0111\u1ea7u<\/td>\n<td>Ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u0129nh vi\u1ec5n ho\u1eb7c n\u1ebfu b\u00e1c s\u0129 \u0111\u00e1nh gi\u00e1 v\u1eabn s\u1eed d\u1ee5ng \u0111\u01b0\u1ee3c cho b\u1ec7nh nh\u00e2n, n\u00ean ng\u1eebng thu\u1ed1c cho \u0111\u1ebfn khi h\u1ed3i ph\u1ee5c v\u1ec1 m\u1ee9c \u0111\u1ed9 0-1<\/td>\n<td>50%<\/td>\n<\/tr>\n<tr>\n<td>Xu\u1ea5t hi\u1ec7n l\u1ea7n 2<\/td>\n<td colspan=\"2\">Ng\u01b0ng \u0111i\u1ec1u tr\u1ecb v\u0129nh vi\u1ec5n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-weight: 400;\">Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Xalvobin 500mg film-coated tablet trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Kh\u00f4ng d\u00f9ng trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m nghi\u00eam tr\u1ecdng v\u00e0 kh\u00f4ng d\u1ef1 \u0111o\u00e1n tr\u01b0\u1edbc v\u1edbi fluropyridin.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">M\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh nh\u00e2n thi\u1ebfu h\u1ee5t dihydropyridine dehydrogenase (DPD).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ph\u1ee5 n\u1eef mang thai v\u00e0 cho con b\u00fa<\/span><\/p>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh nh\u00e2n c\u00f3 b\u1ea1ch c\u1ea7u gi\u1ea3m, b\u1ea1ch c\u1ea7u trung t\u00ednh gi\u1ea3m ho\u1eb7c gi\u1ea3m ti\u1ec3u c\u1ea7u n\u1eb7ng.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh nh\u00e2n suy gan, suy th\u1eadn n\u1eb7ng<\/span><\/p>\n<p><span style=\"font-weight: 400;\">B\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb v\u1edbi sorivudin ho\u1eb7c c\u00e1c thu\u1ed1c c\u00f9ng nh\u00f3m nh\u01b0 brivudin.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Xalvobin 500mg film-coated tablet<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Th\u1eadn tr\u1ecdng<\/span><\/h3>\n<p><i><span style=\"font-weight: 400;\">\u0110\u1ed9c t\u00ednh gi\u1edbi h\u1ea1n li\u1ec1u d\u00f9ng<\/span><\/i><span style=\"font-weight: 400;\">: bao g\u1ed3m ti\u00eau ch\u1ea3y, \u0111au b\u1ee5ng, bu\u1ed3n n\u00f4n, vi\u00eam mi\u1ec7ng v\u00e0 h\u1ed9i ch\u1ee9ng b\u00e0n tay- b\u00e0n ch\u00e2n (ph\u1ea3n \u1ee9ng da b\u00e0n tay \u2013 b\u00e0n ch\u00e2n, r\u1ed1i lo\u1ea1n c\u1ea3m gi\u00e1c \u0111\u1ecf da l\u00f2ng b\u00e0n tay &#8211; b\u00e0n ch\u00e2n). Ph\u1ea7n l\u1edbn c\u00e1c t\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd c\u00f3 th\u1ec3 h\u1ed3i ph\u1ee5c v\u00e0 kh\u00f4ng c\u1ea7n ph\u1ea3i ng\u01b0ng \u0111i\u1ec1u tr\u1ecb v\u0129nh vi\u1ec5n, m\u1eb7c d\u00f9 v\u1eabn c\u1ea7n ph\u1ea3i ng\u1eebng thu\u1ed1c ho\u1eb7c gi\u1ea3m li\u1ec1u.\u00a0<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">Ti\u00eau ch\u1ea3y<\/span><\/i><span style=\"font-weight: 400;\">: B\u1ec7nh nh\u00e2n b\u1ecb ti\u00eau ch\u1ea3y n\u1eb7ng n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i c\u1ea9n th\u1eadn v\u00e0 n\u1ebfu b\u1ecb m\u1ea5t n\u01b0\u1edbc, c\u1ea7n b\u00f9 n\u01b0\u1edbc v\u00e0 \u0111i\u1ec7n gi\u1ea3i. C\u00f3 th\u1ec3 s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ti\u00eau ch\u1ea3y ti\u00eau chu\u1ea9n (v\u00ed d\u1ee5 loperamid). Theo ph\u00e2n lo\u1ea1i c\u1ee7a NCIC CTC, ti\u00eau ch\u1ea3y \u0111\u1ed9 2 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 t\u0103ng s\u1ed1 l\u1ea7n \u0111\u1ea1i ti\u1ec7n t\u1edbi 4-6 l\u1ea7n\/ ng\u00e0y ho\u1eb7c \u0111\u1ea1i ti\u1ec7n v\u00e0o ban \u0111\u00eam, ti\u00eau ch\u1ea3y \u0111\u1ed9 3 l\u00e0 t\u0103ng s\u1ed1 l\u1ea7n \u0111\u1ea1i ti\u1ec7n t\u1edbi 7-9 l\u1ea7n ng\u00e0y ho\u1eb7c kh\u00f4ng kim l\u1ea1i \u0111\u01b0\u1ee3c v\u00e0 kh\u00f4ng h\u1ea5p thu. Ti\u00eau ch\u1ea3y \u0111\u1ed9 4 l\u00e0 t\u0103ng s\u1ed1 l\u1ea7n \u0111\u1ea1i ti\u1ec7n t\u1edbi 210 l\u1ea7n ng\u00e0y ho\u1eb7c \u0111\u1ea1i ti\u1ec7n ra r\u1ea5t nhi\u1ec1u m\u00e1u ho\u1eb7c c\u1ea9n ph\u1ea3i ti\u00eam truy\u1ec1n h\u1ed7 tr\u1ee3. Gi\u1ea3m li\u1ec1u n\u00ean \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng n\u1ebfu c\u1ea7n thi\u1ebft..\u00a0<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">M\u1ea5t n\u01b0\u1edbc<\/span><\/i><span style=\"font-weight: 400;\">: M\u1ea5t n\u01b0\u1edbc n\u00ean \u0111\u01b0\u1ee3c ng\u0103n ch\u1eb7n ho\u1eb7c \u0111i\u1ec1u ch\u1ec9nh \u0111\u00fang l\u00fac, Nh\u1eefng b\u1ec7nh nh\u00e2n ch\u00e1n \u0103n, suy nh\u01b0\u1ee3c, bu\u1ed3n n\u00f4n, n\u00f4n ho\u1eb7c ti\u00eau ch\u1ea3y c\u00f3 th\u1ec3 m\u1ea5t n\u01b0\u1edbc m\u1ed9t c\u00e1ch nhanh ch\u00f3ng. N\u1ebfu m\u1ea5t n\u01b0\u1edbc \u0111\u1ed9 2 (ho\u1eb7c cao h\u01a1n) xu\u1ea5t hi\u1ec7n, n\u00ean ng\u1eebng \u0111i\u1ec1u tr\u1ecb capecitabin ngay l\u1eadp t\u1ee9c v\u00e0 m\u1ea5t n\u01b0\u1edbc \u0111\u01b0\u1ee3c hi\u1ec7u ch\u1ec9nh. Kh\u00f4ng n\u00ean \u0111i\u1ec1u tr\u1ecb l\u1ea1i cho \u0111\u1ebfn khi b\u1ec7nh nh\u00e2n v\u1eabn c\u00f2n m\u1ea5t n\u01b0\u1edbc v\u00e0 b\u1ea5t k\u1ef3 nguy\u00ean nh\u00e2n s\u1edbm n\u00e0o g\u00e2y ra ph\u1ea3i \u0111\u01b0\u1ee3c hi\u1ec7u ch\u1ec9nh ho\u1eb7c ki\u1ec3m so\u00e1t. N\u1ebfn \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u cho nh\u1eefng t\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd \u0111\u1ebfn s\u1edbm khi c\u1ea7n thi\u1ebft\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kh\u00f4ng d\u00f9ng cho ph\u1ee5 n\u1eef mang thai v\u00e0 cho con b\u00fa.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Capecitabin c\u00f3 \u1ea3nh h\u01b0\u1edfng nh\u1eb9 ho\u1eb7c trung b\u00ecnh \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. Capecitabin c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t, m\u1ec7t m\u1ecfi v\u00e0 bu\u1ed3n n\u00f4n.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\n<p><b>Capecitabine 500mg<\/b><span style=\"font-weight: 400;\"> c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. Ng\u1eebng s\u1eed d\u1ee5ng capecitabine v\u00e0 g\u1ecdi b\u00e1c s\u0129 ngay n\u1ebfu:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Ti\u00eau ch\u1ea3y n\u1eb7ng\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Ti\u00eau ch\u1ea3y ra m\u00e1u k\u00e8m theo \u0111au b\u1ee5ng d\u1eef d\u1ed9i v\u00e0 s\u1ed1t<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Bu\u1ed3n n\u00f4n nghi\u00eam tr\u1ecdng ho\u1eb7c ch\u00e1n \u0103n khi\u1ebfn b\u1ea1n \u0103n \u00edt h\u01a1n b\u00ecnh th\u01b0\u1eddng<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">N\u00f4n m\u1eeda (nhi\u1ec1u h\u01a1n m\u1ed9t l\u1ea7n trong 24 gi\u1edd)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">S\u1ed1t\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">V\u1ebft lo\u00e9t ho\u1eb7c v\u1ebft lo\u00e9t trong mi\u1ec7ng, \u0111\u1ecf ho\u1eb7c s\u01b0ng mi\u1ec7ng ho\u1eb7c l\u01b0\u1ee1i, kh\u00f3 \u0103n ho\u1eb7c nu\u1ed1t<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">V\u00e0ng da (v\u00e0ng da ho\u1eb7c m\u1eaft)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Tri\u1ec7u ch\u1ee9ng m\u1ea5t n\u01b0\u1edbc \u2013 c\u1ea3m th\u1ea5y r\u1ea5t kh\u00e1t ho\u1eb7c n\u00f3ng, kh\u00f4ng th\u1ec3 \u0111i ti\u1ec3u, \u0111\u1ed5 m\u1ed3 h\u00f4i nhi\u1ec1u ho\u1eb7c da n\u00f3ng v\u00e0 kh\u00f4<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u201cH\u1ed9i ch\u1ee9ng tay v\u00e0 ch\u00e2n&#8221; &#8211; \u0111au, \u0111au, \u0111\u1ecf, s\u01b0ng, ph\u1ed3ng r\u1ed9p ho\u1eb7c bong tr\u00f3c da \u1edf tay ho\u1eb7c ch\u00e2n<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">V\u1ea5n \u0111\u1ec1 v\u1ec1 tim \u2013 \u0111au ng\u1ef1c, nh\u1ecbp tim kh\u00f4ng \u0111\u1ec1u, s\u01b0ng t\u1ea5y \u1edf ch\u00e2n d\u01b0\u1edbi, t\u0103ng c\u00e2n nhanh, c\u1ea3m th\u1ea5y l\u00e2ng l\u00e2ng ho\u1eb7c kh\u00f3 th\u1edf<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">S\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o m\u00e1u th\u1ea5p \u2013 s\u1ed1t, \u1edbn l\u1ea1nh, m\u1ec7t m\u1ecfi, l\u1edf mi\u1ec7ng, l\u1edf da, d\u1ec5 b\u1ea7m t\u00edm, ch\u1ea3y m\u00e1u b\u1ea5t th\u01b0\u1eddng, da nh\u1ee3t nh\u1ea1t, tay ch\u00e2n l\u1ea1nh, c\u1ea3m th\u1ea5y nh\u1eb9 \u0111\u1ea7u ho\u1eb7c kh\u00f3 th\u1edf.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 c\u00f3 th\u1ec3 b\u1ecb tr\u00ec ho\u00e3n ho\u1eb7c ng\u1eebng v\u0129nh vi\u1ec5n n\u1ebfu g\u1eb7p ph\u1ea3i m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 nh\u1ea5t \u0111\u1ecbnh.<\/span><\/p>\n<p><b>Xalvobin 500mg t\u00e1c d\u1ee5ng ph\u1ee5<\/b><span style=\"font-weight: 400;\"> th\u01b0\u1eddng g\u1eb7p c\u00f3 th\u1ec3 bao g\u1ed3m:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Bu\u1ed3n n\u00f4n, n\u00f4n, ti\u00eau ch\u1ea3y, \u0111au d\u1ea1 d\u00e0y<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">C\u1ea3m th\u1ea5y y\u1ebfu \u0111u\u1ed1i ho\u1eb7c m\u1ec7t m\u1ecfi<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">H\u1ed9i ch\u1ee9ng tay ch\u00e2n<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">B\u1ec7nh v\u00e0ng da.<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n<p><i><span style=\"font-weight: 400;\">D\u00f9ng thu\u1ed1c l\u00e0m lo\u00e3ng m\u00e1u<\/span><\/i><span style=\"font-weight: 400;\"> (warfarin, Coumadin, Jantoven) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng trong v\u00e0 ngay sau khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng capecitabine. Nguy c\u01a1 n\u00e0y cao h\u01a1n \u1edf ng\u01b0\u1eddi l\u1edbn tr\u00ean 60 tu\u1ed5i.<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">Folinic acid<\/span><\/i><span style=\"font-weight: 400;\">: m\u1ed9t nghi\u00ean c\u1ee9u k\u1ebft h\u1ee3p v\u1edbi capecitabin v\u00e0 acid folinic ch\u1ec9 ra r\u1eb1ng acid folinic kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u1edbn \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a capecitabin v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3. Tuy nhi\u00ean, acid folinic c\u00f3 m\u1ed9t t\u00e1c \u0111\u1ed9ng tr\u00ean d\u01b0\u1ee3c l\u1ef1c h\u1ecdc c\u1ee7a capecitabin v\u00e0 \u0111\u1ed9c t\u00ednh c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 b\u1ecb t\u0103ng l\u00ean b\u1edfi acid folinic: li\u1ec1u d\u00f9ng n\u1ea1p t\u1ed1i \u0111a (MTD) c\u1ee7a capecitabin \u0111\u01a1n \u0111\u1ed9c d\u00f9ng ch\u1ebf \u0111\u1ed9 kh\u00f4ng li\u00ean t\u1ee5c l\u00e0 3000mg\/m m\u1ed7i ng\u00e0y trong khi n\u00f3 l\u00e0 ch\u1ec9 c\u00f3 2000mg\/m m\u1ed7i ng\u00e0y khi capecitabin \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi acid folinic (30mg u\u1ed1ng hai l\u1ea7n m\u1ed7i ng\u00e0y).<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">Phenytoin<\/span><\/i><span style=\"font-weight: 400;\">:\u00a0 N\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng c\u1ee7a Phenytoin t\u0103ng d\u1eabn c\u00e1c tri\u1ec7u ch\u1ee9ng nhi\u1ec5m \u0111\u1ed9c phenytoin trong m\u1ed9t v\u00e0i tr\u01b0\u1eddng h\u1ee3p \u0111\u01a1n l\u1ebb \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi d\u00f9ng capecitabin c\u00f9ng v\u1edbi phenytoin. Nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng phenytoin c\u00f9ng v\u1edbi capecitabin n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i th\u01b0\u1eddng xuy\u00ean v\u00ec n\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u1edfng c\u1ee7a phenytoin t\u0103ng.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sorivudin v\u00e0 c\u00e1c thu\u1ed1c t\u01b0\u01a1ng t\u1ef1: T\u01b0\u01a1ng t\u00e1c thu\u1ed1c thu\u1ed1c c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng gi\u1eefa sorivudin v\u00e0 5-FU, do sorivudin \u1ee9c ch\u1ebf dihydropyridin dehydrogenase, \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 trong y v\u0103n. T\u01b0\u01a1ng t\u00e1c n\u00e0y, d\u1eabn t\u1edbi t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a dihydropyrimidin dehydrogenase, c\u00f3 th\u1ec3 nguy hi\u1ec3m \u0111\u1ebfn t\u00ednh m\u1ea1ng.<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">Thu\u1ed1c kh\u00e1ng acid<\/span><\/i><span style=\"font-weight: 400;\">: khi s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p v\u1edbi Xalvobin c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a thu\u1ed1c.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Kh\u00f4ng d\u00f9ng thu\u1ed1c cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Tri\u1ec7u ch\u1ee9ng: N\u00f4n, ti\u00eau ch\u1ea3y, xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a, suy t\u1ee7y,&#8230;.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">X\u1eed tr\u00ed: c\u1ea7n \u0111\u1ebfn ngay c\u01a1 s\u1edf y t\u1ebf ho\u1eb7c g\u1eb7p b\u00e1c s\u0129 \u0111\u1ec3 k\u1ecbp th\u1eddi x\u1eed tr\u00ed<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Thu\u1ed1c Xalvobin 500mg film-coated tablet gi\u00e1 bao nhi\u00eau? b\u00e1n \u1edf \u0111\u00e2u?<\/span><\/h2>\n<p><b>Xalvobin 500mg gi\u00e1 bao nhi\u00eau<\/b><span style=\"font-weight: 400;\"> ? Thu\u1ed1c hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c b\u00e1n t\u1ea1i Nh\u00e0 thu\u1ed1c D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng, gi\u00e1 s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadp t\u1ea1i \u0111\u1ea7u trang. Hi\u1ec7n nay, nh\u00e0 thu\u1ed1c ch\u00fang t\u00f4i h\u1ed7 tr\u1ee3 giao h\u00e0ng to\u00e0n qu\u1ed1c. Qu\u00fd kh\u00e1ch h\u00e0ng c\u00f3 th\u1ec3 li\u00ean h\u1ec7 qua s\u1ed1 hotline 0868 552 633 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n k\u1ecbp th\u1eddi.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">K\u00ednh m\u1eddi qu\u00fd kh\u00e1ch xem th\u00eam m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m kh\u00e1c t\u1ea1i nh\u00e0 thu\u1ed1c c\u1ee7a ch\u00fang t\u00f4i c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng:\u00a0\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/hmm88i.com\/drug\/xeloda-500mg\/\"><span style=\"font-weight: 400;\">Xeloda <\/span><\/a><span style=\"font-weight: 400;\">l\u00e0 thu\u1ed1c thu\u1ed9c nh\u00f3m k\u00ecm h\u00e3m t\u1ebf b\u00e0o c\u00f3 th\u1ec3 d\u00f9ng \u0111\u01a1n ho\u1eb7c ph\u1ed1i h\u1ee3p c\u00f9ng c\u00e1c thu\u1ed1c kh\u00e1c c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m ch\u1eadm ho\u1eb7c ng\u0103n ch\u1eb7n s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 v\u1edbi th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 Capecitabine 500mg, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty Hoffmann-La Roche Inc \u2013 M\u1ef8. Hi\u1ec7n <\/span><b>Xeloda 500mg<\/b><span style=\"font-weight: 400;\"> \u0111ang \u0111\u01b0\u1ee3c b\u00e1n v\u1edbi gi\u00e1 7.500.000 \u0111\u1ed3ng\/ H\u1ed9p 12 v\u1ec9 x 10 vi\u00ean n\u00e9n.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">T\u1ea1i sao n\u00ean l\u1ef1a ch\u1ecdn thu\u1ed1c Xalvobin 500mg film-coated tablet?<\/span><\/h2>\n<table>\n<tbody>\n<tr>\n<td>\u01afu \u0111i\u1ec3m<\/td>\n<td>Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/td>\n<\/tr>\n<tr>\n<td>Xalvobin 500mg c\u00f3 ch\u1ee9a Capecitabine 500mg d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng di c\u0103n, h\u1ed7 tr\u1ee3 b\u1ec7nh nh\u00e2n sau ph\u1eabu thu\u1eadt ung th\u01b0 \u0111\u1ea1i tr\u00e0ng giai \u0111o\u1ea1n III,&#8230;<\/p>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m Remedica Ltd, c\u00f3 c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t hi\u1ec7n \u0111\u1ea1i, ti\u00ean ti\u1ebfn \u0111\u1ea1t chu\u1ea9n GMP n\u00ean c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng, \u0111\u01b0\u1ee3c ki\u1ec3m ch\u1ee9ng tr\u00ean l\u00e2m s\u00e0ng.<\/p>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n \u0111\u1ea3m b\u1ea3o \u0111\u01b0\u1ee3c \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh, d\u1ec5 mang \u0111i, s\u1eed d\u1ee5ng v\u00e0 b\u1ea3o qu\u1ea3n.<\/td>\n<td>Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng c\u00f3 th\u1ec3 g\u1eb7p c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 t\u01b0\u01a1ng t\u00e1c n\u00ean c\u1ea7n th\u1eadn tr\u1ecdng.<\/p>\n<p>Thu\u1ed1c kh\u00f4ng d\u00f9ng cho ph\u1ee5 n\u1eef mang thai v\u00e0 cho con b\u00fa.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u0110\u01b0\u1ee3c vi\u1ebft b\u1edfi chuy\u00ean gia c\u1ee7a Drugs.com. (Th\u1eddi gian c\u1eadp nh\u1ea5t l\u1ea7n cu\u1ed1i ng\u00e0y 25 th\u00e1ng 5 n\u0103m 2023). <\/span><i><span style=\"font-weight: 400;\">Capecitabine<\/span><\/i><span style=\"font-weight: 400;\">. Th\u1eddi gian truy c\u1eadp ng\u00e0y 14 th\u00e1ng 11 n\u0103m 2023, t\u1eeb <\/span><a href=\"https:\/\/www.drugs.com\/mtm\/capecitabine.html\" rel=\"noopener\"><span style=\"font-weight: 400;\">https:\/\/www.drugs.com\/mtm\/capecitabine.html<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Xalvobin 500mg c\u00f3 ch\u1ee9a Capecitabine 500mg d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng di c\u0103n, h\u1ed7 tr\u1ee3 b\u1ec7nh nh\u00e2n sau ph\u1eabu thu\u1eadt ung th\u01b0 \u0111\u1ea1i tr\u00e0ng giai \u0111o\u1ea1n III,&#8230;<\/p>\n","protected":false},"author":490,"featured_media":56781,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-56776","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product\/56776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/users\/490"}],"replies":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/comments?post=56776"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media\/56781"}],"wp:attachment":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media?parent=56776"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_cat?post=56776"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_tag?post=56776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}