{"id":52610,"date":"2023-10-28T15:47:29","date_gmt":"2023-10-28T08:47:29","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=52610"},"modified":"2025-07-24T13:59:54","modified_gmt":"2025-07-24T06:59:54","slug":"cefotaxone-1g","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/cefotaxone-1g\/","title":{"rendered":"Cefotaxone 1g"},"content":{"rendered":"
Trong b\u00e0i vi\u1ebft n\u00e0y, D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Cefotaxone 1g<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c – trang thi\u1ebft b\u1ecb y t\u1ebf B\u00ecnh \u0110\u1ecbnh (Bidiphar), c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-23776-15<\/strong><\/p>\n M\u1ed7i l\u1ecd Cefotaxone 1g<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n D\u1ea1ng b\u00e0o ch\u1ebf: Thu\u1ed1c b\u1ed9t pha ti\u00eam.<\/p>\n S\u0110K: VD-23776-15. Cefotaxim thu\u1ed9c nh\u00f3m kh\u00e1ng sinh Cephalosporin th\u1ebf h\u1ec7 3 v\u1edbi ph\u1ed5 kh\u00e1ng khu\u1ea9n r\u1ed9ng, \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p v\u1ecf t\u1ebf b\u00e0o vi khu\u1ea9n t\u1eeb \u0111\u00f3 c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n.<\/p>\n Cefotaxim so v\u1edbi c\u00e1c cephalosporin thu\u1ed9c th\u1ebf h\u1ec7 1 v\u00e0 2 t\u00e1c \u0111\u1ed9ng l\u00ean vi khu\u1ea9n Gram \u00e2m m\u1ea1nh h\u01a1n, b\u1ec1n h\u01a1n \u0111\u1ed1i v\u1edbi ph\u1ea7n l\u1edbn c\u00e1c beta lactamase, t\u00e1c d\u1ee5ng tr\u00ean vi khu\u1ea9n Gram d\u01b0\u01a1ng l\u1ea1i y\u1ebfu h\u01a1n c\u00e1c cephalosporin th\u1ebf h\u1ec7 1. Cefotaxim b\u1ecb kh\u00e1ng b\u1edfi c\u00e1c lo\u1ea1i vi khu\u1ea9n sau: Enterococcus, Staphylococcus kh\u00e1ng methicillin, Listeria, Pseudomonas cepiacia, Xanthomonas maltophilia, Acinetobacter baumanii, Clostridium difficile, c\u00e1c vi khu\u1ea9n k\u1ef5 kh\u00ed Gram \u00e2m.<\/p>\n Sau khi ti\u00eam, Cefotaxim \u0111\u01b0\u1ee3c h\u1ea5p thu r\u1ea5t nhanh. Kh\u1ea3 n\u0103ng g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 40%. Desacetyl cefotaxim v\u00e0 Cefotaxim ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i trong c\u00e1c m\u00f4 v\u00e0 d\u1ecbch c\u01a1 th\u1ec3. Thu\u1ed1c v\u00e0o \u0111\u01b0\u1ee3c d\u1ecbch n\u00e3o tu\u1ef7 v\u1edbi n\u1ed3ng \u0111\u1ed9 c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb, \u0111\u1eb7c bi\u1ec7t khi vi\u00eam m\u00e0ng n\u00e3o.<\/p>\n Cefotaxim qua \u0111\u01b0\u1ee3c nhau thai v\u00e0 s\u1eefa m\u1eb9. Cefotaxim 1g sau khi ti\u00eam b\u1eafp 30 ph\u00fat, thu\u1ed1c \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft thanh l\u00e0 20,5 mcg\/L. Ti\u00eam t\u0129nh m\u1ea1ch Cefotaxim 1g v\u00e0 2g, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a thu\u1ed1c trong huy\u1ebft thanh \u0111\u1ea1t \u0111\u01b0\u1ee3c l\u1ea7n l\u01b0\u1ee3t l\u00e0 101,7 mcg\/mL v\u00e0 214,4 mcg\/mL.<\/p>\n Cefotaxim chuy\u1ec3n ho\u00e1 \u1edf gan m\u1ed9t ph\u1ea7n th\u00e0nh desacetyl cefotaxim v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n ho\u00e1 kh\u00f4ng ho\u1ea1t t\u00ednh kh\u00e1c. Kho\u1ea3ng 20 \u2013 36% li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft \u1edf d\u1ea1ng kh\u00f4ng chuy\u1ec3n h\u00f3a qua th\u1eadn, \u1edf d\u1ea1ng desacetyl cefotaxim 15 \u2013 25% v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh 20 \u2013 25%.<\/p>\n Cefotaxim v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 c\u00f3 \u1edf m\u1eadt v\u00e0 ph\u00e2n v\u1edbi n\u1ed3ng \u0111\u1ed9 t\u01b0\u01a1ng \u0111\u1ed1i cao. Th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 1 gi\u1edd trong huy\u1ebft t\u01b0\u01a1ng\u00a0 v\u00e0 c\u1ee7a desacetyl cefotaxim l\u00e0 kho\u1ea3ng 1,5 gi\u1edd.<\/p>\n Cefotaxone 1g ti\u00eam<\/strong> d\u00f9ng \u0111i\u1ec1u tr\u1ecb c\u00e1c nhi\u1ec5m khu\u1ea9n n\u1eb7ng v\u00e0 nguy k\u1ecbch g\u00e2y ra b\u1edfi vi khu\u1ea9n nh\u1ea1y c\u1ea3m v\u1edbi Cefotaxim, bao g\u1ed3m: nhi\u1ec5m khu\u1ea9n huy\u1ebft, \u00e1p xe n\u00e3o, vi\u00eam m\u00e0ng n\u00e3o (tr\u1eeb vi\u00eam m\u00e0ng n\u00e3o do Listeria monocytogenes), vi\u00eam m\u00e0ng trong tim, l\u1eadu, vi\u00eam ph\u1ed5i, th\u01b0\u01a1ng h\u00e0n, \u0111i\u1ec1u tr\u1ecb t\u1eadp trung, ph\u1ed1i h\u1ee3p v\u1edbi Metronidazol tr\u1ecb nhi\u1ec5m khu\u1ea9n n\u1eb7ng trong \u1ed5 b\u1ee5ng v\u00e0 d\u1ef1 ph\u00f2ng nhi\u1ec5m khu\u1ea9n sau m\u1ed5 ti\u1ec1n li\u1ec7t tuy\u1ebfn, m\u1ed5 l\u1ea5y thai, m\u1ed5 n\u1ed9i soi.<\/p>\n Ti\u00eam b\u1eafp s\u00e2u, ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm trong th\u1eddi gian t\u1eeb 3 – 5 ph\u00fat, ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch ch\u1eadm v\u1edbi th\u1eddi gian t\u1eeb 20 – 60 ph\u00fat. D\u00f9ng thu\u1ed1c th\u00eam 3 – 4 ng\u00e0y n\u1eefa sau khi th\u00e2n nhi\u1ec7t b\u00ecnh th\u01b0\u1eddng ho\u1eb7c \u0111\u00e3 tri\u1ec7t h\u1ebft vi khu\u1ea9n. \u0110\u1ed1i v\u1edbi nhi\u1ec5m khu\u1ea9n g\u00e2y ra b\u1edfi li\u00ean c\u1ea7u tan m\u00e1u beta nh\u00f3m A th\u00ec ph\u1ea3i \u0111i\u1ec1u tr\u1ecb \u00edt nh\u1ea5t l\u00e0 10 ng\u00e0y.<\/p>\n D\u00f9ng c\u00e1c dung d\u1ecbch sau \u0111\u1ec3 pha dung d\u1ecbch ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch: Dextrose 5%, Natri clorid 0,9%, Ringer lactate, Dextrose – Natri clorid, hay b\u1ea5t k\u00ec dung d\u1ecbch truy\u1ec1n t\u0129nh m\u1ea1ch n\u00e0o c\u00f3 pH 5 – 7.<\/p>\n Li\u1ec1u cefotaxim cho tr\u1ebb em<\/strong>: 100 – 150 mg\/kg\/ng\u00e0y (tr\u1ebb s\u01a1 sinh: 50 mg\/kg\/ng\u00e0y) chia th\u00e0nh 2-4 l\u1ea7n. T\u0103ng li\u1ec1u l\u00ean t\u1edbi 200 mg\/kg\/ng\u00e0y (tr\u1ebb s\u01a1 sinh:100-150 mg\/kg\/ng\u00e0y) n\u1ebfu c\u1ea7n thi\u1ebft.<\/p>\n Suy th\u1eadn n\u1eb7ng: (\u0111\u1ed9 thanh th\u1ea3i creatinin < 10ml\/ph\u00fat) sau khi d\u00f9ng li\u1ec1u t\u1ea5n c\u00f4ng th\u00ec gi\u1ea3m \u00bd\u00a0 li\u1ec1u, gi\u1eef nguy\u00ean s\u1ed1 l\u1ea7n d\u00f9ng thu\u1ed1c trong ng\u00e0y; t\u1ed1i \u0111a 2 \u1ed1ng\/ng\u00e0y.<\/p>\n Qu\u00e1 m\u1eabn v\u1edbi Cephalosporin ho\u1eb7c c\u00e1c beta-lactam kh\u00e1c.<\/p>\n Khai th\u00e1c ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh v\u1edbi Penicilin, Cephalosporin ho\u1eb7c thu\u1ed1c kh\u00e1c tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Cefotaxim.<\/p>\n Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng Cefotaxim cho ng\u01b0\u1eddi d\u1ecb \u1ee9ng v\u1edbi Penicilin.<\/p>\n Theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn n\u1ebfu d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y \u0111\u1ed9c v\u1edbi th\u1eadn (nh\u01b0 Aminoglycosid).<\/p>\n D\u01b0\u01a1ng t\u00ednh gi\u1ea3 v\u1edbi test Coombs, c\u00e1c x\u00e9t nghi\u1ec7m \u0111\u01b0\u1eddng ni\u1ec7u v\u1edbi c\u00e1c ch\u1ea5t kh\u1eed m\u00e0 kh\u00f4ng d\u00f9ng ph\u01b0\u01a1ng ph\u00e1p enzym c\u00f3 th\u1ec3 x\u1ea3y ra khi d\u00f9ng Cefotaxim.<\/p>\nCefotaxone 1g l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n
Th\u00e0nh ph\u1ea7n<\/h3>\n
\n
Tr\u00ecnh b\u00e0y<\/h3>\n
\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd v\u00e0 1 \u1ed1ng n\u01b0\u1edbc c\u1ea5t pha ti\u00eam 4ml.
\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam.<\/p>\nThu\u1ed1c Cefotaxone 1g c\u00f3 t\u00e1c d\u1ee5ng g\u00ec?<\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n
\nPh\u1ed5 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean c\u00e1c vi khu\u1ea9n sau: E. coli, Enterobacter, Salmonella, Serratia, P. mirabilis, P.
\nvulgaris, Shigella, Citrobacter diversus, Providencia, Klebsiella pneumonia, Morganella morganii, K. oxytoca, Haemophilus spp., Streptococcus, Haemophilus influenzae, Staphylococcus, Neisseria, Branhamella catarrhalis, Peptostreptococcus, Clostridium perfringens, Borrellia, Pasteurella multocida, Burgdorferi, Corynebacterium diphteriae Aeromonas hydrophilia.<\/p>\nD\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n
Thu\u1ed1c Cefotaxone 1g \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Cefotaxone 1g<\/h2>\n
C\u00e1ch d\u00f9ng<\/h3>\n
Li\u1ec1u d\u00f9ng<\/h3>\n
\n
\nTh\u01b0\u1eddng d\u00f9ng 2-6 \u1ed1ng\/ng\u00e0y, chia th\u00e0nh 2 – 3 l\u1ea7n. Trong nhi\u1ec5m khu\u1ea9n n\u1eb7ng c\u00f3 th\u1ec3 truy\u1ec1n t\u0129nh m\u1ea1ch 12 \u1ed1ng\/ng\u00e0y, chia th\u00e0nh 3 – 6 l\u1ea7n.<\/li>\nKh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Cefotaxone 1g trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Cefotaxone 1g<\/h2>\n
Th\u1eadn tr\u1ecdng<\/h3>\n
T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n