Th\u00e0nh ph\u1ea7n<\/span><\/h3>\nThu\u1ed1c Efexor XR 37.5mg<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n\n- Ho\u1ea1t ch\u1ea5t: Venlafaxine (d\u01b0\u1edbi d\u1ea1ng venlafaxin HCl) c\u00f3 h\u00e0m l\u01b0\u1ee3ng 75mg.<\/span><\/li>\n
- T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean g\u1ed3m cellulose vi tinh th\u1ec3, hypromellose 2208, ethyl Cellulose 50 cps, hypromellose 2910, b\u1ed9t Talc.<\/span><\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean nang<\/span><\/p>\nTr\u00ecnh b\u00e0y<\/span><\/h3>\nS\u0110K: VN-18951-15<\/span><\/p>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 v\u1ec9 x 7 vi\u00ean<\/span><\/p>\nXu\u1ea5t x\u1ee9: Ireland<\/span><\/p>\nT\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Efexor XR 37.5mg<\/span><\/h2>\nC\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\nVenlafaxin v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh l\u00e0 O-desmethylvenlafaxin (ODV) l\u00e0 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh s\u1ef1 t\u00e1i thu h\u1ed3i serotonin v\u00e0 norepinephrin v\u00e0 c\u0169ng \u1ee9c ch\u1ebf y\u1ebfu s\u1ef1 t\u00e1i thu h\u1ed3i dopamin. T\u00e1c d\u1ee5ng ch\u1ed1ng tr\u1ea7m c\u1ea3m c\u1ee7a venlafaxin \u0111\u01b0\u1ee3c cho l\u00e0 do kh\u1ea3 n\u0103ng t\u00e1c d\u1ee5ng tr\u00ean ho\u1ea1t \u0111\u1ed9ng d\u1eabn truy\u1ec1n th\u1ea7n kinh \u1edf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng. Venlafaxin v\u00e0 ODV kh\u00f4ng c\u00f3 \u00e1i l\u1ef1c v\u1edbi receptor muscarinic, histaminergic ho\u1eb7c aradrenergic in vitro. T\u00e1c d\u1ee5ng t\u1ea1i c\u00e1c receptor n\u00e0y c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng kh\u00e1c \u0111\u00e3 th\u1ea5y \u1edf c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00e1c nh\u01b0 t\u00e1c d\u1ee5ng kh\u00e1ng cholin, t\u00e1c d\u1ee5ng an th\u1ea7n v\u00e0 t\u00e1c d\u1ee5ng tr\u00ean h\u1ec7 tim m\u1ea1ch. Trong c\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng tr\u00ean c\u00e1c lo\u00e0i g\u1eb7m nh\u1ea5m, venlafaxin \u0111\u00e3 cho th\u1ea5y t\u00e1c d\u1ee5ng ch\u1ed1ng tr\u1ea7m c\u1ea3m v\u00e0 t\u00e1c d\u1ee5ng gi\u1ea3i lo \u00e2u, v\u00e0 l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng nh\u1eadn th\u1ee9c.<\/span><\/p>\n\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n\n\n\n| H\u1ea5p thu<\/span><\/td>\n | \u00cdt nh\u1ea5t 92% venlafaxin \u0111\u01b0\u1ee3c h\u1ea5p thu sau khi u\u1ed1ng li\u1ec1u \u0111\u01a1n venlafaxin gi\u1ea3i ph\u00f3ng trung b\u00ecnh. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i c\u1ee7a thu\u1ed1c t\u1eeb 40% \u0111\u1ebfn 45% do chuy\u1ec3n h\u00f3a tr\u01b0\u1edbc khi x\u00e2m nh\u1eadp v\u00e0o tu\u1ea7n ho\u00e0n chung.<\/span><\/td>\n<\/tr>\n\n| Ph\u00e2n b\u1ed1<\/span><\/td>\n | N\u1ed3ng \u0111\u1ed9 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh c\u1ee7a c\u1ea3 venlafaxin v\u00e0 ODV trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00f2ng 3 ng\u00e0y khi \u0111i\u1ec1u tr\u1ecb li\u1ec1u l\u1eb7p l\u1ea1i v\u1edbi venlafaxin gi\u1ea3i ph\u00f3ng t\u1ee9c th\u1eddi.<\/span><\/td>\n<\/tr>\n\n| Chuy\u1ec3n h\u00f3a<\/span><\/td>\n | Venlafaxin b\u1ecb chuy\u1ec3n h\u00f3a m\u1ea1nh \u1edf gan.<\/span><\/td>\n<\/tr>\n\n| Th\u1ea3i tr\u1eeb<\/span><\/td>\n | Venlafaxin v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu qua th\u1eadn.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nThu\u1ed1c Efexor XR 37.5mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n\n- \u00d0i\u1ec1u tr\u1ecb c\u00e1c r\u1ed1i lo\u1ea1n tr\u1ea7m c\u1ea3m ch\u1ee7 y\u1ebfu.<\/span><\/li>\n
- Ng\u0103n ng\u1eeba tr\u1ea7m c\u1ea3m t\u00e1i ph\u00e1t v\u00e0 tr\u1ea7m c\u1ea3m t\u00e1i di\u1ec5n.<\/span><\/li>\n
- \u0110i\u1ec1u tr\u1ecb c\u00e1c r\u1ed1i lo\u1ea1n lo \u00e2u to\u00e0n th\u1ec3.<\/span><\/li>\n
- \u0110i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lo \u00e2u x\u00e3 h\u1ed9i.<\/span><\/li>\n
- \u0110i\u1ec1u tr\u1ecb c\u00e1c r\u1ed1i lo\u1ea1n ho\u1ea3ng lo\u1ea1n.<\/span><\/li>\n<\/ul>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Efexor XR 37.5mg<\/span><\/h2>\nC\u00e1ch d\u00f9ng<\/span><\/h3>\nVi\u00ean nang gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i n\u00ean \u0111\u01b0\u1ee3c u\u1ed1ng trong b\u1eefa \u0103n v\u00e0o c\u00f9ng m\u1ed9t th\u1eddi \u0111i\u1ec3m m\u1ed7i ng\u00e0y. U\u1ed1ng nguy\u00ean vi\u00ean nang c\u00f9ng v\u1edbi n\u01b0\u1edbc, kh\u00f4ng chia nh\u1ecf, nhai ho\u1eb7c h\u00f2a tan vi\u00ean nang, ho\u1eb7c c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng b\u1eb1ng c\u00e1ch m\u1edf nang thu\u1ed1c c\u1ea9n th\u1eadn v\u00e0 r\u1eafc to\u00e0n b\u1ed9 l\u01b0\u1ee3ng thu\u1ed1c c\u00f3 trong nang v\u00e0o m\u1ed9t th\u00eca \u0111\u1ea7y n\u01b0\u1edbc s\u1ed1t t\u00e1o. Sau \u0111\u00f3 nu\u1ed1t h\u1ed7n h\u1ee3p thu\u1ed1c\/th\u1ee9c \u0103n n\u00e0y, (kh\u00f4ng nhai) v\u00e0 u\u1ed1ng ti\u1ebfp theo \u0111\u00f3 m\u1ed9t c\u1ed1c n\u01b0\u1edbc \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o \u0111\u00e3 u\u1ed1ng h\u1ebft to\u00e0n b\u1ed9 vi h\u1ea1t.<\/span><\/p>\nLi\u1ec1u d\u00f9ng<\/span><\/h3>\n\n\n\n| C\u00e1c r\u1ed1i lo\u1ea1n tr\u1ea7m c\u1ea3m ch\u1ee7 y\u1ebfu<\/span><\/td>\n | \n\n- Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o cho vi\u00ean nang gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i venlafaxine l\u00e0 75mg, d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y. Nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec1u ban \u0111\u1ea7u 75mg\/ng\u00e0y c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u d\u1ea7n d\u1ea7n l\u00ean li\u1ec1u t\u1ed1i \u0111a 225 mg\/ng\u00e0y.<\/span><\/li>\n
- \u00a0Li\u1ec1u khuy\u1ebfn c\u00e1o c\u1ee7a vi\u00ean n\u00e9n gi\u1ea3i ph\u00f3ng ngay venlafaxine cho b\u1ec7nh nh\u00e2n tr\u1ea7m c\u1ea3m v\u1eeba ph\u1ea3i l\u00ean t\u1edbi 225 mg m\u1ed7i ng\u00e0y, nh\u01b0ng m\u1ed9t nghi\u00ean c\u1ee9u cho th\u1ea5y nh\u1eefng b\u1ec7nh nh\u00e2n tr\u1ea7m c\u1ea3m n\u1eb7ng h\u01a1n \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec1u cao h\u01a1n. Trung b\u00ecnh 350mg\/ng\u00e0y (kho\u1ea3ng 150-375mg\/ng\u00e0y).<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| R\u1ed1i lo\u1ea1n lo \u00e2u to\u00e0n th\u1ec3<\/span><\/td>\n | Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o cho vi\u00ean nang gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i venlafaxine l\u00e0 75 mg, d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y. Nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec1u ban \u0111\u1ea7u 75 mg\/ng\u00e0y c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u d\u1ea7n d\u1ea7n l\u00ean li\u1ec1u t\u1ed1i \u0111a 225 mg\/ng\u00e0y. B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i v\u00e0 \u0111\u00e1nh gi\u00e1 trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/span><\/td>\n<\/tr>\n\n| R\u1ed1i lo\u1ea1n lo \u00e2u x\u00e3 h\u1ed9i<\/span><\/td>\n | Li\u1ec1u kh\u1edfi \u0111\u1ea7u c\u1ee7a vi\u00ean nang venlafaxin gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 75 mg, d\u00f9ng m\u1ed9t l\u1ea7n trong ng\u00e0y. Kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y t\u0103ng li\u1ec1u l\u00e0m t\u0103ng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a thu\u1ed1c. C\u1ea7n l\u01b0u \u00fd theo d\u00f5i v\u00e0 \u0111\u00e1nh gi\u00e1 b\u1ec7nh nh\u00e2n trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/span><\/td>\n<\/tr>\n\n| R\u1ed1i lo\u1ea1n ho\u1ea3ng lo\u1ea1n<\/span><\/td>\n | Li\u1ec1u c\u1ee7a vi\u00ean nang venlafaxin gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 37,5 mg\/ng\u00e0y d\u00f9ng trong 7 ng\u00e0y. Sau \u0111\u00f3 n\u00ean t\u0103ng li\u1ec1u l\u00ean 75 mg\/ng\u00e0y. B\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec1u 75 mg\/ng\u00e0y c\u00f3 th\u1ec3 d\u00f9ng li\u1ec1u t\u0103ng d\u1ea7n \u0111\u1ebfn m\u1ee9c li\u1ec1u t\u1ed1i \u0111a l\u00e0 225 mg\/ng\u00e0y. C\u1ea7n theo d\u00f5i v\u00e0 \u0111\u00e1nh gi\u00e1 b\u1ec7nh nh\u00e2n trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/span><\/td>\n<\/tr>\n\n| S\u1eed d\u1ee5ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n suy th\u1eadn<\/span><\/td>\n | \n\n- V\u1edbi b\u1ec7nh nh\u00e2n suy th\u1eadn c\u00f3 m\u1ee9c l\u1ecdc c\u1ea7u th\u1eadn (GFR) t\u1eeb 10 \u0111\u1ebfn 70 mL\/ph\u00fat, n\u00ean gi\u1ea3m t\u1eeb 25% \u0111\u1ebfn 50% t\u1ed5ng li\u1ec1u venlafaxin h\u00e0ng ng\u00e0y.<\/span><\/li>\n
- V\u1edbi b\u1ec7nh nh\u00e2n \u0111ang th\u1ea9m t\u00edch m\u00e1u, n\u00ean gi\u1ea3m 50% t\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y c\u1ee7a venlafaxin.<\/span><\/li>\n
- Do c\u00f3 s\u1ef1 thay \u0111\u1ed5i l\u1edbn v\u1ec1 \u0111\u1ed9 thanh th\u1ea3i gi\u1eefa c\u00e1c b\u1ec7nh nh\u00e2n, c\u1ea7n c\u00e1 th\u1ec3 h\u00f3a li\u1ec1u d\u00f9ng cho t\u1eebng b\u1ec7nh nh\u00e2n.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| S\u1eed d\u1ee5ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan<\/span><\/td>\n | \n\n- \u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n suy gan \u1edf m\u1ee9c \u0111\u1ed9 t\u1eeb nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh, n\u00ean gi\u1ea3m 50% t\u1ed5ng li\u1ec1u venlafaxin h\u00e0ng ng\u00e0y. \u1ede m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, c\u00f3 th\u1ec3 gi\u1ea3m h\u01a1n 50% li\u1ec1u venlafaxin.<\/span><\/li>\n
- Do c\u00f3 s\u1ef1 thay \u0111\u1ed5i l\u1edbn v\u1ec1 \u0111\u1ed9 thanh th\u1ea3i gi\u1eefa c\u00e1c b\u1ec7nh nh\u00e2n, c\u1ea7n c\u00e1 th\u1ec3 h\u00f3a li\u1ec1u d\u00f9ng cho t\u1eebng b\u1ec7nh nh\u00e2n.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| S\u1eed d\u1ee5ng thu\u1ed1c cho tr\u1ebb em v\u00e0 thi\u1ebfu ni\u00ean<\/span><\/td>\n | Ch\u01b0a c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u cho vi\u1ec7c s\u1eed d\u1ee5ng venlafaxin \u1edf b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 18 tu\u1ed5i.<\/span><\/td>\n<\/tr>\n\n| S\u1eed d\u1ee5ng thu\u1ed1c tr\u00ean b\u1ec7nh nh\u00e2n cao tu\u1ed5i<\/span><\/td>\n | Kh\u00f4ng c\u00f3 hi\u1ec7u ch\u1ec9nh li\u1ec1u \u0111\u1eb7c bi\u1ec7t n\u00e0o \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o d\u1ef1a tr\u00ean tu\u1ed5i c\u1ee7a b\u1ec7nh nh\u00e2n.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n C\u00e1ch ng\u01b0ng Venlafaxin: <\/span>N\u1ebfu ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng venlafaxine, n\u00ean gi\u1ea3m li\u1ec1u d\u1ea7n d\u1ea7n n\u1ebfu c\u00f3 th\u1ec3. Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi vi\u00ean nang venlafexin gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i, quy tr\u00ecnh gi\u1ea3m li\u1ec1u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1eb1ng c\u00e1ch gi\u1ea3m 75mg \/ng\u00e0y, th\u1eddi gian gi\u1eefa c\u00e1c l\u1ea7n gi\u1ea3m li\u1ec1u l\u00e0 1 tu\u1ea7n. Th\u1eddi gian c\u1ea7n thi\u1ebft \u0111\u1ec3 gi\u1ea3m li\u1ec1u ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng, th\u1eddi gian \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u00e1p \u1ee9ng c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n.<\/span><\/p>\nKh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Efexor XR 37.5mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/span><\/h2>\n\n- M\u1eabn c\u1ea3m v\u1edbi venlafaxin ho\u1eb7c b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/span><\/li>\n
- Kh\u00f4ng d\u00f9ng \u0111\u1ed3ng th\u1eddi venlafaxin v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf enzym monoamin oxidase (MAOI).<\/span><\/li>\n
- Ch\u1ec9 \u0111\u01b0\u1ee3c d\u00f9ng venlafaxin \u00edt nh\u1ea5t 14 ng\u00e0y sau khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi MAOI. Kho\u1ea3ng c\u00e1ch n\u00e0y c\u00f3 th\u1ec3 r\u00fat ng\u1eafn l\u1ea1i trong tr\u01b0\u1eddng h\u1ee3p d\u00f9ng c\u00e1c thu\u1ed1c MAOI c\u00f3 h\u1ed3i ph\u1ee5c. N\u00ean ng\u1eebng d\u00f9ng venlafaxin \u00edt nh\u1ea5t 7 ng\u00e0y tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c thu\u1ed1c MAOI.<\/span><\/li>\n<\/ul>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Efexor XR 37.5mg<\/span><\/h2>\nTh\u1eadn tr\u1ecdng<\/span><\/h3>\n\n- T\u1ea5t c\u1ea3 c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng venlafaxin n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i c\u1ea9n th\u1eadn v\u00e0 quan s\u00e1t ch\u1eb7t ch\u1ebd c\u00e1c d\u1ea5u hi\u1ec7u b\u1ec7nh c\u1ea3nh l\u00e2m s\u00e0ng x\u1ea5u \u0111i v\u00e0 n\u1ebfu b\u1ec7nh nh\u00e2n c\u00f3 \u00fd \u0111\u1ecbnh t\u1ef1 t\u1eed.<\/span><\/li>\n
- Nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5 h\u1ecdc cho th\u1ea5y nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng t\u0103ng l\u00ean \u1edf c\u00e1c b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf t\u00e1i thu h\u1ed3i serotonin bao g\u1ed3m c\u1ea3 venlafaxin.<\/span><\/li>\n
- Hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c tr\u00ean b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 18 tu\u1ed5i ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh r\u00f5.<\/span><\/li>\n
- C\u00e1c ph\u1ea3n \u1ee9ng t\u01b0\u01a1ng t\u1ef1 h\u1ed9i ch\u1ee9ng an th\u1ea7n kinh \u00e1c t\u00ednh (NMS).<\/span><\/li>\n
- Gi\u00e3n \u0111\u1ed3ng t\u1eed c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n khi d\u00f9ng venlafaxin.<\/span><\/li>\n
- Venlafaxin ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 tr\u00ean b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed g\u1ea7n \u0111\u00e2y b\u1ecb nh\u1ed3i m\u00e1u c\u01a1 tim ho\u1eb7c b\u1ec7nh tim kh\u00f4ng \u1ed5n \u0111\u1ecbnh. Do \u0111\u00f3, c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng venlafaxin cho c\u00e1c b\u1ec7nh nh\u00e2n n\u00e0y.<\/span><\/li>\n
- C\u00e1c c\u01a1n co gi\u1eadt c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng venlafaxin.<\/span><\/li>\n
- H\u01b0ng c\u1ea3m\/H\u01b0ng c\u1ea3m nh\u1eb9 c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n tr\u00ean m\u1ed9t t\u1ef7 l\u1ec7 nh\u1ecf b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n d\u00f9ng c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m, bao g\u1ed3m c\u1ea3 venlafaxin.<\/span><\/li>\n
- Th\u00e1i \u0111\u1ed9 hung h\u00e3n c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n tr\u00ean t\u1ef7 l\u1ec7 nh\u1ecf b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m, bao g\u1ed3m c\u1ea3 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng venlafaxin, trong tr\u01b0\u1eddng h\u1ee3p n\u00e0y n\u00ean gi\u1ea3m li\u1ec1u ho\u1eb7c ng\u1eebng d\u00f9ng thu\u1ed1c.<\/span><\/li>\n
- H\u1ea1 natri m\u00e1u.<\/span><\/li>\n
- C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf thu h\u1ed3i serotonin c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u.<\/span><\/li>\n
- \u0110\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 khi k\u1ebft h\u1ee3p venlafaxin v\u1edbi c\u00e1c thu\u1ed1c gi\u1ea3m c\u00e2n, bao g\u1ed3m phentermin, ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh ch\u1eafc ch\u1eafn.<\/span><\/li>\n
- T\u0103ng cholesterol huy\u1ebft thanh c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng d\u01b0\u1ee3c ghi nh\u1eadn tr\u00ean 5,3% b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng venlafaxin v\u00e0 0% \u1edf nh\u00f3m b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c trong \u00edt nh\u1ea5t 3 th\u00e1ng trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c.<\/span><\/li>\n
- C\u00e1c t\u00e1c d\u1ee5ng khi ng\u01b0ng thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5 th\u01b0\u1eddng x\u1ea3y ra khi d\u00f9ng thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m, do \u0111\u00f3 v\u1edbi b\u1ea5t c\u1ee9 d\u1ea1ng b\u00e0o ch\u1ebf n\u00e0o c\u1ee7a venlafaxin, c\u1ea7n gi\u1ea3m d\u1ea7n li\u1ec1u khi ng\u01b0ng thu\u1ed1c v\u00e0 theo d\u00f5i b\u1ec7nh nh\u00e2n c\u1ea9n th\u1eadn.<\/span><\/li>\n
- C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng kh\u00f4ng cho th\u1ea5y b\u1eb1ng ch\u1ee9ng v\u1ec1 s\u1ef1 l\u1ec7 thu\u1ed9c thu\u1ed1c, xu\u1ea5t hi\u1ec7n dung n\u1ea1p, ho\u1eb7c c\u1ea7n t\u0103ng li\u1ec1u theo th\u1eddi gian.<\/span><\/li>\n<\/ul>\n
T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\n\n\n\n| R\u1ea5t th\u01b0\u1eddng g\u1eb7p<\/span><\/td>\n | \n\n- R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh: \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n: m\u1ea5t\u00a0 ng\u1ee7<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n ti\u00eau ho\u00e1: Bu\u1ed3n n\u00f4n, kh\u00f4 mi\u1ec7ng, t\u00e1o b\u00f3n<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n da v\u00e0 m\u00f4 d\u01b0\u1edbi da: t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| Th\u01b0\u1eddng g\u1eb7p<\/span><\/td>\n | \n\n- R\u1ed1i lo\u1ea1n trao \u0111\u1ed5i ch\u1ea5t v\u00e0 dinh d\u01b0\u1ee1ng: Ch\u00e1n \u0103n.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n: Lo l\u1eafng, k\u00edch \u0111\u1ed9ng, r\u1ed1i lo\u1ea1n kho\u00e1i c\u1ea3m, g\u1eb7p c\u00e1c gi\u1ea5c m\u01a1 b\u1ea5t th\u01b0\u1eddng.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh: B\u1ed3n ch\u1ed3n, d\u1ecb c\u1ea3m, run.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n m\u1eaft: Gi\u1ea3m th\u1ecb l\u1ef1c, gi\u00e3n \u0111\u1ed3ng t\u1eed.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n tai v\u00e0 tai trong: \u00d9 tai.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n tim: T\u0103ng huy\u1ebft \u00e1p, \u0111\u1ecf b\u1eebng m\u1eb7t.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n m\u1ea1ch: Nh\u1ecbp tim \u0111\u1eadp nhanh.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p, ng\u1ef1c v\u00e0 trung th\u1ea5t: Kh\u00f3 th\u1edf<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n ti\u00eau ho\u00e1: Ti\u00eau ch\u1ea3y, n\u00f4n.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n da v\u00e0 m\u00f4 d\u01b0\u1edbi da: Ph\u00e1t ban, ng\u1ee9a, \u0111\u1ed5 m\u1ed3 h\u00f4i.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n th\u1eadn v\u00e0 ti\u1ebft ni\u1ec7u: Kh\u00f3 ti\u1ec3u, ti\u1ec3u b\u00ed.<\/span><\/li>\n
- M\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c c\u01a1 th\u1ec3.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng c\u01b0\u01a1ng d\u01b0\u01a1ng.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n| \u00cdt g\u1eb7p<\/span><\/td>\n | \n\n- Tr\u1ea1ng th\u00e1i l\u00fa l\u1eabn, h\u01b0ng c\u1ea3m, \u1ea3o gi\u00e1c.<\/span><\/li>\n
- R\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng, rung gi\u1eadt c\u01a1.<\/span><\/li>\n
- H\u1ea1 huy\u1ebft \u00e1p th\u1ebf \u0111\u1ee9ng.<\/span><\/li>\n
- X\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan b\u1ea5t th\u01b0\u1eddng.<\/span><\/li>\n
- N\u1ed5i m\u1ec1 \u0111ay.<\/span><\/li>\n
- Ti\u1ec3u ti\u1ec7n kh\u00f4ng ki\u1ec3m so\u00e1t<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
T\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\n\n- C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf enzym monoamin oxidase (MAOI).<\/span><\/li>\n
- C\u00e1c thu\u1ed1c t\u00e1c d\u1ee5ng tr\u00ean th\u1ea7n kinh trung \u01b0\u01a1ng.<\/span><\/li>\n
- H\u1ed9i ch\u1ee9ng serotonin.<\/span><\/li>\n
- C\u00e1c thu\u1ed1c g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT.<\/span><\/li>\n
- Indinavir.<\/span><\/li>\n
- Ethanol.<\/span><\/li>\n
- Haloperidol.<\/span><\/li>\n
- Cimetidin.<\/span><\/li>\n
- Imipramin.<\/span><\/li>\n
- Ketoconazol.<\/span><\/li>\n
- Metoprolol.\u00a0<\/span><\/li>\n
- Risperidon.\u00a0<\/span><\/li>\n
- Diazepam.<\/span><\/li>\n
- Lithium.<\/span><\/li>\n
- C\u00e1c thu\u1ed1c li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/span><\/li>\n
- C\u00e1c thu\u1ed1c chuy\u1ec3n h\u00f3a qua isoenzym cytochrom P450.<\/span><\/li>\n
- Kh\u1ea3 n\u0103ng \u1ea3nh h\u01b0\u1edfng c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1c t\u1edbi venlafaxin: C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP2D6, C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4, C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP2D6 v\u00e0 CYP3A4.<\/span><\/li>\n<\/ul>\n
L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/span><\/h3>\n | | | | | | | | | | | | | | |