{"id":51023,"date":"2023-10-25T16:52:07","date_gmt":"2023-10-25T09:52:07","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=51023"},"modified":"2025-07-24T14:00:02","modified_gmt":"2025-07-24T07:00:02","slug":"arthur-200mg","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/arthur-200mg\/","title":{"rendered":"Arthur 200Mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Arthur 200Mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Davipharm – C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m \u0110\u1ea1t Vi Ph\u00fa, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-11982-10<\/b>.<\/span><\/p>\n

Arthur 200Mg l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n

Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n

Arthur 200Mg<\/b> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n

Trimebutine maleat \u2026\u2026\u2026\u2026\u2026\u2026\u2026.. 200mg<\/span><\/p>\n

T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/span><\/p>\n

D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/span><\/p>\n

Tr\u00ecnh b\u00e0y<\/span><\/h3>\n

S\u0110K: VD-11982-10<\/span><\/p>\n

Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 v\u1ec9, m\u1ed7i v\u1ec9 10 vi\u00ean<\/span><\/p>\n

Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/span><\/p>\n

Thu\u1ed1c Arthur 200Mg c\u00f3 t\u00e1c d\u1ee5ng g\u00ec ?<\/span><\/h2>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\n

\u1ede n\u1ed3ng \u0111\u1ed9 cao, <\/span>trimebutine <\/b>\u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf d\u00f2ng Ca2+ ngo\u1ea1i b\u00e0o v\u00e0o t\u1ebf b\u00e0o c\u01a1 tr\u01a1n th\u00f4ng qua k\u00eanh Ca2+ lo\u1ea1i L ph\u1ee5 thu\u1ed9c v\u00e0o \u0111i\u1ec7n \u00e1p v\u00e0 gi\u1ea3i ph\u00f3ng th\u00eam Ca2+ t\u1eeb kho d\u1ef1 tr\u1eef Ca2+ n\u1ed9i b\u00e0o. Trimebutine \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 kh\u1ea3 n\u0103ng li\u00ean k\u1ebft v\u1edbi tr\u1ea1ng th\u00e1i b\u1ea5t ho\u1ea1t c\u1ee7a k\u00eanh canxi v\u1edbi \u00e1i l\u1ef1c cao, gi\u1ea3m d\u00f2ng canxi l\u00e0m suy gi\u1ea3m qu\u00e1 tr\u00ecnh kh\u1eed c\u1ef1c m\u00e0ng v\u00e0 gi\u1ea3m nhu \u0111\u1ed9ng ru\u1ed9t. N\u00f3 c\u0169ng \u1ee9c ch\u1ebf d\u00f2ng K+ ra b\u00ean ngo\u00e0i \u0111\u1ec3 \u0111\u00e1p \u1ee9ng v\u1edbi qu\u00e1 tr\u00ecnh kh\u1eed c\u1ef1c m\u00e0ng c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tr\u01a1n GI \u1edf \u0111i\u1ec1u ki\u1ec7n ngh\u1ec9 ng\u01a1i th\u00f4ng qua \u1ee9c ch\u1ebf k\u00eanh K+ ch\u1ec9nh l\u01b0u b\u1ecb tr\u00ec ho\u00e3n v\u00e0 k\u00eanh K+ ph\u1ee5 thu\u1ed9c Ca2+, d\u1eabn \u0111\u1ebfn co c\u01a1. Trimebutine li\u00ean k\u1ebft v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 opioid v\u1edbi \u0111\u1ed9 ch\u1ecdn l\u1ecdc cao h\u01a1n so v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 opioid delta ho\u1eb7c kappa nh\u01b0ng c\u00f3 \u00e1i l\u1ef1c th\u1ea5p h\u01a1n c\u00e1c ph\u1ed1i t\u1eed t\u1ef1 nhi\u00ean c\u1ee7a ch\u00fang. C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 (N-monodesmethyl-trimebutine ho\u1eb7c nor-trimebutine), c\u0169ng \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 li\u00ean k\u1ebft v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 opoid tr\u00ean m\u00e0ng n\u00e3o v\u00e0 c\u00e1c kh\u1edbp th\u1ea7n kinh c\u1ee7a c\u01a1 ru\u1ed9t.<\/span><\/p>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n

H\u1ea5p thu: D\u1ea1ng baz\u01a1 t\u1ef1 do ho\u1eb7c d\u1ea1ng mu\u1ed1i c\u1ee7a trimebutine \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh ch\u00f3ng sau khi u\u1ed1ng, v\u1edbi n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 1 gi\u1edd u\u1ed1ng. Th\u1eddi gian \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau khi u\u1ed1ng m\u1ed9t li\u1ec1u duy nh\u1ea5t 200 mg trimebutine l\u00e0 0,80 gi\u1edd.<\/span><\/p>\n

Ph\u00e2n b\u1ed1: Trimebutine c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng t\u00edch l\u0169y trong d\u1ea1 d\u00e0y v\u00e0 th\u00e0nh ru\u1ed9t \u1edf n\u1ed3ng \u0111\u1ed9 cao nh\u1ea5t. T\u1ef7 l\u1ec7 chuy\u1ec3n thai nhi \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 th\u1ea5p.<\/span><\/p>\n

Chuy\u1ec3n h\u00f3a: Nortrimebutine, ho\u1eb7c N-monodesmethyltrimebutine, l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh duy tr\u00ec ho\u1ea1t \u0111\u1ed9ng d\u01b0\u1ee3c l\u00fd tr\u00ean ru\u1ed9t k\u1ebft. Ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y c\u00f3 th\u1ec3 tr\u1ea3i qua qu\u00e1 tr\u00ecnh N-demethyl h\u00f3a l\u1ea7n th\u1ee9 hai \u0111\u1ec3 t\u1ea1o th\u00e0nh N-didesmethyltrimebutine. C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh trong n\u01b0\u1edbc ti\u1ec3u kh\u00e1c (2-amino, 2-methylamino ho\u1eb7c 2-dimethylamino-2-phenylbutan-1-ol) c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh th\u00f4ng qua qu\u00e1 tr\u00ecnh th\u1ee7y ph\u00e2n li\u00ean k\u1ebft este c\u1ee7a c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u00e3 kh\u1eed methyl ho\u1eb7c th\u1ee7y ph\u00e2n ban \u0111\u1ea7u li\u00ean k\u1ebft este c\u1ee7a trimebutine, sau \u0111\u00f3 l\u00e0 N tu\u1ea7n t\u1ef1. -demethyl h\u00f3a. Trimebutine c\u0169ng d\u1ec5 b\u1ecb li\u00ean h\u1ee3p sunfat v\u00e0\/ho\u1eb7c axit glucuronic.<\/span><\/p>\n

Th\u1ea3i tr\u1eeb: S\u1ef1 th\u1ea3i tr\u1eeb qua th\u1eadn chi\u1ebfm \u01b0u th\u1ebf trong khi s\u1ef1 b\u00e0i ti\u1ebft qua ph\u00e2n c\u0169ng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y (5-12%). Kho\u1ea3ng 94% li\u1ec1u u\u1ed1ng trimebutine \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00e1c nhau v\u00e0 d\u01b0\u1edbi 2,4% t\u1ed5ng l\u01b0\u1ee3ng thu\u1ed1c u\u1ed1ng v\u00e0o \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c ban \u0111\u1ea7u kh\u00f4ng thay \u0111\u1ed5i trong n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i kho\u1ea3ng 1 gi\u1edd sau khi u\u1ed1ng li\u1ec1u duy nh\u1ea5t 2 mg\/kg v\u00e0 2,77 gi\u1edd sau khi u\u1ed1ng li\u1ec1u duy nh\u1ea5t 200 mg.<\/span><\/p>\n

Thu\u1ed1c Arthur 200Mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n

Thu\u1ed1c Arthur 200Mg \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/span><\/p>\n