Th\u00e0nh ph\u1ea7n<\/span><\/h3>\nM\u1ed7i vi\u00ean thu\u1ed1c <\/span>Zhekof-80<\/b> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/span><\/p>\n\n- Telmisartan 80mg<\/span><\/li>\n
- T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7.<\/span><\/li>\n<\/ul>\n
D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/span><\/p>\nTr\u00ecnh b\u00e0y<\/span><\/h3>\nS\u0110K: VD-27458-17<\/span><\/p>\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 6 v\u1ec9 x 10 vi\u00ean<\/span><\/p>\nXu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/span><\/p>\nT\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Zhekof-80<\/span><\/h2>\nC\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng\u00a0<\/span><\/h3>\nZhekof ch\u1ee9a <\/span>Telmisartan – <\/b>ch\u1ea5t \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc tr\u00ean th\u1ee5 th\u1ec3 angiotensin II l\u00e0m gi\u00e3n m\u1ea1ch, gi\u1ea3m k\u00edch th\u00edch l\u00ean th\u1eadn t\u1eeb \u0111\u00f3 gi\u1ea3m ti\u1ebft aldosteron n\u00ean \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p.<\/span><\/p>\n\u00a0V\u00ec c\u00f3 t\u00e1c \u0111\u1ed9ng ch\u1ecdn l\u1ecdc tr\u00ean AT1 g\u1ea5p 3000 l\u1ea7n \u00e1i l\u1ef1c v\u1edbi AT2 n\u00ean Telmisartan kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 gi\u00e1ng h\u00f3a bradykinin nh\u1edd v\u1eady \u00edt g\u1eb7p c\u00e1c ph\u1ea3n \u1ee9ng kh\u00f4ng mong mu\u1ed1n nh\u01b0 ho tr\u00ean nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n.<\/span><\/p>\n\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n\n- H\u1ea5p thu<\/span><\/li>\n<\/ul>\n
Telmisartan c\u00f3 sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i kho\u1ea3ng 42% \u0111\u1ebfn 58% t\u00f9y thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng thu\u1ed1c v\u00e0 h\u1ea5p thu nhanh qua ti\u00eau h\u00f3a.\u00a0<\/span><\/p>\n\n- Ph\u00e2n b\u1ed1<\/span><\/li>\n<\/ul>\n
Tr\u00ean 99% Telmisartan li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng m\u00e0 nhi\u1ec1u nh\u1ea5t l\u00e0 li\u00ean k\u1ebft v\u1edbi\u00a0 albumin v\u00e0 alpha-acid glycoprotein.<\/span><\/p>\n\n- Chuy\u1ec3n h\u00f3a<\/span><\/li>\n<\/ul>\n
Telmisartan chuy\u1ec3n h\u00f3a th\u00e0nh d\u1ea1ng kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh do c\u00e1ch li\u00ean k\u1ebft v\u1edbi glucoronid.<\/span><\/p>\n\n- Th\u1ea3i tr\u1eeb<\/span><\/li>\n<\/ul>\n
T\/2 c\u1ee7a Telmisartan l\u00e0 24 gi\u1edd, \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua ph\u00e2n d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i v\u00e0 c\u00f3 l\u01b0\u1ee3ng nh\u1ecf kho\u1ea3ng 1% th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u.<\/span><\/p>\nThu\u1ed1c Zhekof-80 tr\u1ecb b\u1ec7nh g\u00ec?<\/span><\/h2>\nThu\u1ed1c Zhekof-80 gi\u00fap gi\u00e3n m\u1ea1ch, h\u1ea1 huy\u1ebft \u00e1p\u00a0 \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/span><\/p>\n\n- \u0110i\u1ec1u tr\u1ecb ng\u01b0\u1eddi b\u1ecb t\u0103ng huy\u1ebft \u00e1p c\u00f3 th\u1ec3 d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p kh\u00e1c ho\u1eb7c ch\u1ec9 d\u00f9ng Zhekof \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u00f9y theo t\u00ecnh tr\u1ea1ng t\u1eebng ng\u01b0\u1eddi.<\/span><\/li>\n
- D\u1ef1 ph\u00f2ng tim m\u1ea1ch cho ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 cao nh\u01b0 ng\u01b0\u1eddi m\u1eafc ti\u1ec3u \u0111\u01b0\u1eddng \u0111\u00e3 c\u00f3 t\u1ed5n th\u01b0\u01a1ng tr\u00ean c\u00e1c b\u1ed9 ph\u1eadn kh\u00e1c ( type 2), ng\u01b0\u1eddi \u0111ang c\u00f3 v\u1ea5n \u0111\u1ec1 v\u1ec1 tim m\u1ea1ch haowcj c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh tim m\u1ea1ch nh\u01b0 \u0111\u1ed9t qu\u1ef5, b\u1ec7nh m\u1ea1ch v\u00e0nh, b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch ngo\u1ea1i bi\u00ean.<\/span><\/li>\n<\/ul>\n
Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Zhekof-80<\/span><\/h2>\nLi\u1ec1u d\u00f9ng<\/span><\/h3>\nKhi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c Zhekof c\u1ea7n ph\u1ea3i tu\u00e2n th\u1ee7 theo \u0111\u01a1n v\u00e0 h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129 v\u1ec1 li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng thu\u1ed1c.<\/span><\/p>\n\n\n\n| T\u0103ng huy\u1ebft \u00e1p<\/span><\/td>\n | Li\u1ec1u khuy\u1ebfn c\u00e1o: 0,5 vi\u00ean\/1 l\u1ea7n\/ng\u00e0y<\/span><\/p>\n T\u00f9y t\u00ecnh tr\u1ea1ng m\u1ed7i ng\u01b0\u1eddi m\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u t\u1eeb 20mg\/1 l\u1ea7n\/ng\u00e0y \u0111\u1ebfn t\u1ed1i \u0111a 80mg\/1 l\u1ea7n\/ng\u00e0y.\u00a0<\/span><\/td>\n<\/tr>\n\n| D\u1ef1 ph\u00f2ng bi\u1ebfn ch\u1ee9ng tim m\u1ea1ch<\/span><\/td>\n | Li\u1ec1u khuy\u1ebfn c\u00e1o: 1 vi\u00ean\/1 l\u1ea7n\/ng\u00e0y.<\/span><\/p>\n C\u1ea7n theo d\u00f5i huy\u1ebft \u00e1p khi s\u1eed d\u1ee5ng nh\u1ea5t l\u00e0 l\u00fac m\u1edbi d\u00f9ng thu\u1ed1c.<\/span><\/td>\n<\/tr>\n\n| Suy th\u1eadn\u00a0<\/span><\/td>\n | M\u1ee9c \u0111\u1ed9 n\u1eb7ng: kh\u1edfi \u0111\u1ea7u v\u1edbi li\u1ec1u 20mg\/1 l\u1ea7n\/ng\u00e0y v\u00e0 kh\u00f4ng d\u00f9ng v\u1edbi thu\u1ed1c l\u1ee3i ti\u1ec3u n\u1ebfu t\u1ed1c \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn <30 ml\/ph\u00fat.<\/span><\/td>\n<\/tr>\n\n| Suy gan<\/span><\/td>\n | Suy gan m\u1ee9c \u0111\u1ed9 nh\u1eb9, v\u1eeba ho\u1eb7c t\u1eafc m\u1eadt li\u1ec1u t\u1ed1i \u0111a l\u00e0 0,5 vi\u00ean\/1 l\u1ea7n\/ng\u00e0y<\/span><\/p>\n Suy gan m\u1ee9c \u0111\u1ed9 n\u1eb7ng: kh\u00f4ng k\u1ebft h\u1ee3p d\u00f9ng v\u1edbi thu\u1ed1c l\u1ee3i ti\u1ec3u.<\/span><\/td>\n<\/tr>\n\n| Ng\u01b0\u1eddi cao tu\u1ed5i<\/span><\/td>\n | Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u<\/span><\/td>\n<\/tr>\n\n| Tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i<\/span><\/td>\n | Kh\u00f4ng s\u1eed d\u1ee5ng do ch\u01b0a r\u00f5 v\u1ec1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nC\u00e1ch d\u00f9ng<\/span><\/h3>\nM\u1ed7i ng\u00e0y u\u1ed1ng m\u1ed9t l\u1ea7n, thu\u1ed1c kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi b\u1eefa \u0103n nh\u01b0ng b\u1ea1n n\u00ean u\u1ed1ng v\u00e0o c\u00f9ng m\u1ed9t th\u1eddi \u0111i\u1ec3m trong ng\u00e0y.<\/span><\/p>\nTu\u00e2n th\u1ee7 theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 ho\u1eb7c d\u01b0\u1ee3c s\u0129.<\/span><\/p>\nCh\u1ed1ng ch\u1ec9 \u0111\u1ecbnh thu\u1ed1c Zhekof-80\u00a0<\/span><\/h2>\n\n- M\u1eabn c\u1ea3m v\u1edbi Telmisartan ho\u1eb7c c\u00e1c th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c c\u1ee7a thu\u1ed1c Zhekof<\/span><\/li>\n
- Ph\u1ee5 n\u1eef mang thai, cho con b\u00fa<\/span><\/li>\n
- Suy th\u1eadn n\u1eb7ng<\/span><\/li>\n
- T\u1eafc m\u1eadt<\/span><\/li>\n
- Ng\u01b0\u1eddi ti\u1ec3u \u0111\u01b0\u1eddng hay suy th\u1eadn \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng aliskiren\u00a0<\/span><\/li>\n
- Suy gan n\u1eb7ng<\/span><\/li>\n
- Ng\u01b0\u1eddi suy th\u1eadn c\u00f3 n\u1ed3ng \u0111\u1ed9 creatinin m\u00e1u > 250 micromol\/L ho\u1eb7c n\u1ed3ng \u0111\u1ed9 kali m\u00e1u >5 mmol\/L ho\u1eb7c ClCr<\/sub> <30 ml\/ph\u00fat<\/span><\/li>\n<\/ul>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Zhekof-80<\/span><\/h2>\nTh\u1eadn tr\u1ecdng<\/span><\/h3>\nThu\u1ed1c Zhekof-80 l\u00e0 thu\u1ed1c k\u00ea \u0111\u01a1n, ch\u1ec9 d\u00f9ng theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129.<\/span><\/p>\nB\u1ea1n n\u00ean \u0111\u1ecdc k\u1ef9 HDSD thu\u1ed1c Zhekof tr\u01b0\u1edbc khi d\u00f9ng v\u00e0 h\u1ecfi th\u00eam th\u00f4ng tin t\u1eeb b\u00e1c s\u0129 n\u1ebfu c\u1ea7n.<\/span><\/p>\nTh\u1eadn tr\u1ecdng khi d\u00f9ng Zhekof-80 trong tr\u01b0\u1eddng h\u1ee3p:<\/span><\/p>\n\n- Trong th\u1eddi gian mang thai, cho con b\u00fa ho\u1eb7c chu\u1ea9n b\u1ecb mang thai<\/span><\/li>\n
- H\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn<\/span><\/li>\n
- V\u1ea5n \u0111\u1ec1 v\u1ec1 tim m\u1ea1ch<\/span><\/li>\n
- Tr\u01b0\u1eddng h\u1ee3p m\u1ea5t n\u01b0\u1edbc<\/span><\/li>\n
- \u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng<\/span><\/li>\n
- T\u0103ng aldosteron<\/span><\/li>\n
- T\u0103ng kali huy\u1ebft<\/span><\/li>\n
- Suy gan\/suy th\u1eadn<\/span><\/li>\n
- Lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng ho\u1eb7c b\u1ec7nh kh\u00e1c<\/span><\/li>\n
- Ti\u1ec1n s\u1eed b\u1ecb ph\u00f9 m\u1ea1ch<\/span><\/li>\n
- Ng\u01b0\u1eddi da \u0111en<\/span><\/li>\n
- G\u00e2y r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a porphyrin<\/span><\/li>\n<\/ul>\n
T\u00e1c d\u1ee5ng ph\u1ee5<\/span><\/h3>\nKhi s\u1eed d\u1ee5ng Zhekof-80 th\u00ec d\u1eebng u\u1ed1ng v\u00e0 \u0111\u1ebfn c\u01a1 s\u1edf y t\u1ebf g\u1ea7n nh\u1ea5t n\u1ebfu b\u1ea1n g\u1eb7p tri\u1ec7u ch\u1ee9ng sau \u0111\u00e2y: Ph\u00f9 m\u1ea1ch \u0111\u1eb7c bi\u1ec7t \u1edf da, ni\u00eam m\u1ea1c b\u1ecb ph\u00f9 nhanh, nhi\u1ec5m khu\u1ea9n m\u00e1u . M\u1eb7c d\u00f9 ph\u1ea3n \u1ee9ng n\u00e0y hi\u1ebfm g\u1eb7p nh\u01b0ng b\u1ea1n c\u1ea7n ch\u00fa \u00fd.<\/span><\/p>\nZhekof c\u00f3 ho\u1ea1t ch\u1ea5t ch\u00ednh l\u00e0 Telmisartan dung n\u1ea1p t\u1ed1t v\u1edbi \u0111a s\u1ed1 ng\u01b0\u1eddi d\u00f9ng. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Telmisartan \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o nh\u01b0:<\/span><\/p>\n\n\n\n| \u00cdt g\u1eb7p<\/span><\/td>\n | Th\u1ea7n kinh trung \u01b0\u01a1ng<\/span><\/td>\n | ch\u00f3ng m\u1eb7t, k\u00edch \u0111\u1ed9ng, lo l\u1eafng<\/span><\/td>\n<\/tr>\n\n| Ti\u00eau h\u00f3a<\/span><\/td>\n | Kh\u00f4 mi\u1ec7ng, bu\u1ed3n n\u00f4n, \u0111\u1ea7y h\u01a1i, kh\u00f3 ti\u00eau, ch\u00e1n \u0103n, \u0111au b\u1ee5ng, ti\u00eau ch\u1ea3y,tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y.<\/span><\/td>\n<\/tr>\n\n| Ti\u1ebft ni\u1ec7u<\/span><\/td>\n | Nhi\u1ec5m khu\u1ea9n, t\u0103ng creatinin v\u00e0 ure m\u00e1u.<\/span><\/p>\n Gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn<\/span><\/td>\n<\/tr>\n\n| H\u00f4 h\u1ea5p<\/span><\/td>\n | Vi\u00eam h\u1ecdng, vi\u00eam xoang, nhi\u1ec5m khu\u1ea9n h\u00f4 h\u1ea5p v\u00e0 tri\u1ec7u ch\u1ee9ng nh\u01b0 c\u00fam.<\/span><\/td>\n<\/tr>\n\n| X\u01b0\u01a1ng-kh\u1edbp<\/span><\/td>\n | \u0110au l\u01b0ng, \u0111au c\u01a1, co th\u1eaft c\u01a1.<\/span><\/p>\n Tri\u1ec7u ch\u1ee9ng t\u01b0\u01a1ng t\u1ef1 vi\u00eam g\u00e2n.<\/span><\/td>\n<\/tr>\n\n| Chuy\u1ec3n h\u00f3a<\/span><\/td>\n | T\u0103ng kali m\u00e1u<\/span><\/td>\n<\/tr>\n\n| To\u00e0n th\u00e2n<\/span><\/td>\n | M\u1ec7t m\u1ecfi, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, h\u1ea1 huy\u1ebft \u00e1p<\/span><\/p>\n Ph\u00f9 c\u00e1c chi, ph\u00f9 m\u1ea1ch<\/span><\/p>\n\u0110\u1ed5 nhi\u1ec1u m\u1ed3 h\u00f4i, nh\u00ecn m\u1edd<\/span><\/td>\n<\/tr>\n\n| Hi\u1ebfm g\u1eb7p<\/span><\/td>\n | To\u00e0n th\u00e2n<\/span><\/td>\n | Ph\u00f9 m\u1ea1ch<\/span><\/td>\n<\/tr>\n\n| M\u1eaft<\/span><\/td>\n | R\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c<\/span><\/td>\n<\/tr>\n\n| Tim m\u1ea1ch<\/span><\/td>\n | Nh\u1ecbp tim nhanh, ng\u1ea5t, h\u1ea1 huy\u1ebft \u00e1p qu\u00e1 m\u1ee9c<\/span><\/td>\n<\/tr>\n\n| Ti\u00eau h\u00f3a<\/span><\/td>\n | Ch\u1ea3y m\u00e1u d\u1ea1 d\u00e0y ho\u1eb7c ru\u1ed9t<\/span><\/td>\n<\/tr>\n\n| Da<\/span><\/td>\n | Ng\u1ee9a, m\u00e0y \u0111ay, ban da<\/span><\/td>\n<\/tr>\n\n| Gan<\/span><\/td>\n | T\u0103ng men gan<\/span><\/td>\n<\/tr>\n\n| M\u00e1u<\/span><\/td>\n | Gi\u1ea3m hemoglobin<\/span><\/p>\n Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh<\/span><\/td>\n<\/tr>\n\n| Chuy\u1ec3n h\u00f3a<\/span><\/td>\n | t\u0103ng acid uric m\u00e1u, t\u0103ng cholesterol m\u00e1u<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Trong th\u1eddi gian s\u1eed d\u1ee5ng Zhekof-80 th\u00f4ng b\u00e1o v\u1edbi b\u00e1c s\u0129 n\u1ebfu th\u1ea5y xu\u1ea5t hi\u1ec7n b\u1ea5t c\u1ee9 d\u1ea5u hi\u1ec7u l\u1ea1 n\u00e0o \u0111\u1ec3 x\u1eed tr\u00ed.<\/span><\/p>\nT\u01b0\u01a1ng t\u00e1c<\/span><\/h3>\nZhekof-80 c\u00f3 th\u1ec3 x\u1ea3y ra t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c sau:<\/span><\/p>\n\n- C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n<\/span><\/li>\n
- C\u00e1c thu\u1ed1c l\u1ee3i ti\u1ec3u<\/span><\/li>\n
- C\u00e1c thu\u1ed1c ch\u1eb9n beta-adrenergic<\/span><\/li>\n
- Aliskiren<\/span><\/li>\n
- Warfarin<\/span><\/li>\n
- C\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid ho\u1eb7c corticoid<\/span><\/li>\n
- Lithi<\/span><\/li>\n
- Digoxin<\/span><\/li>\n
- Thu\u1ed1c l\u1ee3i ti\u1ec3u gi\u1eef kali<\/span><\/li>\n<\/ul>\n
Li\u1ec7t k\u00ea c\u00e1c thu\u1ed1c ho\u1eb7c th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng b\u1ea1n \u0111ang d\u00f9ng cho b\u00e1c s\u0129 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n ph\u00f9 h\u1ee3p.<\/span><\/p>\nTr\u1ebb em<\/span><\/h3>\nKh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng cho tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i<\/span><\/p>\nL\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/span><\/h3>\n | | | | | | | | | | | | | | | | | | | | |