{"id":46970,"date":"2023-10-04T18:00:54","date_gmt":"2023-10-04T11:00:54","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=46970"},"modified":"2025-07-24T14:02:03","modified_gmt":"2025-07-24T07:02:03","slug":"nexium-10mg","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/nexium-10mg\/","title":{"rendered":"Nexium 10mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Nexium 10mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty AstraZeneca, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-17834-14<\/b>.<\/span><\/p>\n

Nexium 10mg l\u00e0 thu\u1ed1c g\u00ec?<\/span><\/h2>\n

Th\u00e0nh ph\u1ea7n<\/span><\/h3>\n

Thu\u1ed1c c\u1ed1m Nexium 10mg<\/b> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n trong m\u1ed7i g\u00f3i:<\/span><\/p>\n

Esomeprazole\u2026\u2026\u2026\u2026\u2026.. 10mg (d\u01b0\u1edbi d\u1ea1ng magnesi trihydrat)<\/span><\/p>\n

T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7<\/span><\/p>\n

D\u1ea1ng b\u00e0o ch\u1ebf: C\u1ed1m kh\u00e1ng d\u1ecbch d\u1ea1 d\u00e0y \u0111\u1ec3 pha h\u1ed7n d\u1ecbch u\u1ed1ng.<\/span><\/p>\n

Tr\u00ecnh b\u00e0y<\/span><\/h3>\n

S\u0110K: VN-17834-14<\/span><\/p>\n

Quy c\u00e1ch \u0111\u00f3ng g\u00f3i:<\/span><\/p>\n

Xu\u1ea5t x\u1ee9: Th\u1ee5y \u0110i\u1ec3n<\/span><\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Nexium 10mg<\/span><\/h2>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/span><\/h3>\n

Nexium 10mg c\u00f3 ph\u1ea3i kh\u00e1ng sinh kh\u00f4ng<\/b> ?<\/span><\/p>\n

Esomeprazole l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton (PPI) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ki\u1ec3m so\u00e1t b\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y th\u1ef1c qu\u1ea3n (GERD), \u0111\u1ec3 b\u1ea3o v\u1ec7 d\u1ea1 d\u00e0y nh\u1eb1m ng\u0103n ng\u1eeba t\u00e1i ph\u00e1t lo\u00e9t d\u1ea1 d\u00e0y ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng d\u1ea1 d\u00e0y do s\u1eed d\u1ee5ng NSAID l\u00e2u d\u00e0i v\u00e0 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb. \u0111i\u1ec1u tr\u1ecb c\u00e1c t\u00ecnh tr\u1ea1ng t\u0103ng ti\u1ebft b\u1ec7nh l\u00fd bao g\u1ed3m H\u1ed9i ch\u1ee9ng Zollinger-Ellison (ZE). N\u00f3 c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong ph\u00e1c \u0111\u1ed3 4 thu\u1ed1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb H. pylorinhi\u1ec5m tr\u00f9ng c\u00f9ng v\u1edbi c\u00e1c lo\u1ea1i kh\u00e1ng sinh kh\u00e1c.\u00a0<\/span><\/p>\n

Esomeprazole ph\u00e1t huy t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf axit d\u1ea1 d\u00e0y b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n b\u01b0\u1edbc cu\u1ed1i c\u00f9ng trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t axit d\u1ea1 d\u00e0y b\u1eb1ng c\u00e1ch li\u00ean k\u1ebft c\u1ed9ng h\u00f3a tr\u1ecb v\u1edbi c\u00e1c nh\u00f3m sulfhydryl c\u1ee7a cystein c\u00f3 tr\u00ean enzyme (H+, K+)-ATPase \u1edf b\u1ec1 m\u1eb7t b\u00e0i ti\u1ebft c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y. T\u00e1c d\u1ee5ng n\u00e0y d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf s\u1ef1 ti\u1ebft axit d\u1ea1 d\u00e0y c\u01a1 b\u1ea3n v\u00e0 do k\u00edch th\u00edch, b\u1ea5t k\u1ec3 t\u00e1c nh\u00e2n k\u00edch th\u00edch. V\u00ec s\u1ef1 g\u1eafn k\u1ebft c\u1ee7a esomeprazole v\u1edbi enzyme (H+, K+)-ATPase l\u00e0 kh\u00f4ng th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c v\u00e0 enzyme m\u1edbi c\u1ea7n \u0111\u01b0\u1ee3c ti\u1ebft ra \u0111\u1ec3 ti\u1ebfp t\u1ee5c ti\u1ebft axit, n\u00ean th\u1eddi gian t\u00e1c d\u1ee5ng kh\u00e1ng ti\u1ebft c\u1ee7a esomeprazole k\u00e9o d\u00e0i h\u01a1n 24 gi\u1edd. C\u00e1c PPI nh\u01b0 esomeprazole c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a dimethylarginine .dimethylaminohydrolase (DDAH), m\u1ed9t lo\u1ea1i enzyme c\u1ea7n thi\u1ebft cho s\u1ee9c kh\u1ecfe tim m\u1ea1ch. S\u1ef1 \u1ee9c ch\u1ebf DDAH g\u00e2y ra s\u1ef1 t\u00edch t\u1ee5 ch\u1ea5t \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p oxit nitric kh\u00f4ng \u0111\u1ed1i x\u1ee9ng dimethylarginie ( ADMA ), \u0111\u01b0\u1ee3c cho l\u00e0 g\u00e2y ra m\u1ed1i li\u00ean quan gi\u1eefa PPI v\u1edbi vi\u1ec7c t\u0103ng nguy c\u01a1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n m\u1eafc h\u1ed9i ch\u1ee9ng m\u1ea1ch v\u00e0nh kh\u00f4ng \u1ed5n \u0111\u1ecbnh.\u00a0<\/span><\/p>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0<\/span><\/h3>\n

H\u1ea5p th\u1ee5: Sau khi u\u1ed1ng, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng (Cmax) \u0111\u1ea1t \u0111\u01b0\u1ee3c sau kho\u1ea3ng 1,5 gi\u1edd (Tmax). Cmax t\u0103ng t\u1ef7 l\u1ec7 thu\u1eadn khi t\u0103ng li\u1ec1u v\u00e0 di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng theo th\u1eddi gian (AUC) t\u0103ng g\u1ea5p ba l\u1ea7n t\u1eeb 20 \u0111\u1ebfn 40 mg.<\/span><\/p>\n

Ph\u00e2n b\u1ed1: Esomeprazole li\u00ean k\u1ebft 97% v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kh\u00f4ng \u0111\u1ed5i trong kho\u1ea3ng n\u1ed3ng \u0111\u1ed9 t\u1eeb 2 \u0111\u1ebfn 20 umol\/L. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 bi\u1ec3u ki\u1ebfn \u200b\u200b\u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh \u1edf ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh l\u00e0 kho\u1ea3ng 16 L.<\/span><\/p>\n

Chuy\u1ec3n h\u00f3a: Esomeprazole \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu \u1edf gan nh\u1edd h\u1ec7 th\u1ed1ng enzym cytochrome P450 (CYP). C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a esomeprazole kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng ti\u1ebft. Ph\u1ea7n l\u1edbn qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a c\u1ee7a esomeprazole ph\u1ee5 thu\u1ed9c v\u00e0o isoenzym CYP2C19, ch\u1ea5t t\u1ea1o th\u00e0nh c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a hydroxy v\u00e0 desmethyl. L\u01b0\u1ee3ng c\u00f2n l\u1ea1i ph\u1ee5 thu\u1ed9c v\u00e0o CYP3A4 \u0111\u1ec3 t\u1ea1o th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a sulphone.<\/span><\/p>\n

Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a esomeprazole kho\u1ea3ng 1 \u0111\u1ebfn 1,5 gi\u1edd. \u00cdt h\u01a1n 1% thu\u1ed1c g\u1ed1c \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u. Kho\u1ea3ng 80% li\u1ec1u u\u1ed1ng esomeprazole \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh v\u00e0 ph\u1ea7n c\u00f2n l\u1ea1i \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong ph\u00e2n d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh.<\/span><\/p>\n

Thu\u1ed1c Nexium 10mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/span><\/h2>\n

Nexium 10mg<\/b> \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/span><\/p>\n

Tr\u1ebb em t\u1eeb 1-11 tu\u1ed5i<\/span><\/i>: Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y th\u1ef1c qu\u1ea3n<\/span><\/p>\n