{"id":41926,"date":"2023-09-13T11:54:54","date_gmt":"2023-09-13T04:54:54","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=41926"},"modified":"2025-07-24T14:03:49","modified_gmt":"2025-07-24T07:03:49","slug":"demoferidon-500-mg","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/demoferidon-500-mg\/","title":{"rendered":"Demoferidon 500mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, D\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Demoferidon 500mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi DEMO S.A. PHARMACEUTICAL INDUSTRY- Hy L\u1ea1p, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN-21008-18<\/strong><\/p>\n

Demoferidon 500mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n

Th\u00e0nh ph\u1ea7n<\/h3>\n

M\u1ed7i l\u1ecd Demoferidon<\/strong> 500mg\u00a0 ch\u1ee9a:
\nHo\u1ea1t ch\u1ea5t: Deferoxamine mesilate\u2026500 mg.
\nT\u00e1 d\u01b0\u1ee3c: Kh\u00f4ng c\u00f3.
\nD\u1ea1ng b\u00e0o ch\u1ebf: Thu\u1ed1c b\u1ed9t pha dung d\u1ecbch ti\u00eam ho\u1eb7c ti\u00eam truy\u1ec1n<\/p>\n

Tr\u00ecnh b\u00e0y<\/h3>\n

S\u0110K: VN-21008-18.
\nQuy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 10 l\u1ecd.
\nXu\u1ea5t x\u1ee9: Hy L\u1ea1p.<\/p>\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Demoferidon 500mg<\/h2>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n

Deferoxamine thu\u1ed9c nh\u00f3m chelat h\u00f3a. Deferoxamine c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o th\u00e0nh c\u00e1c ph\u1ee9c h\u1ee3p v\u1edbi c\u00e1c ion s\u1eaft h\u00f3a tr\u1ecb ba (ferrioxamin), nh\u00f4m h\u00f3a tr\u1ecb ba (aluminoxamin) b\u1ec1n v\u1eefng v\u00e0 kh\u00f4ng \u0111\u1ed9c. C\u00e1c ph\u1ee9c h\u1ee3p n\u00e0y kh\u00f4ng h\u1ea5p thu qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 t\u1ea5t c\u1ea3 c\u00e1c ph\u1ee9c h\u1ee3p \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh to\u00e0n th\u00e2n do s\u1eed d\u1ee5ng ngo\u00e0i \u0111\u01b0\u1eddng ti\u00eau h\u00f3a s\u1ebd nhanh ch\u00f3ng th\u1ea3i tr\u1eeb qua th\u1eadn m\u00e0 kh\u00f4ng g\u00e2y n\u00ean t\u00e1c h\u1ea1i n\u00e0o.<\/p>\n

Deferoxamine thu nh\u1eadn s\u1eaft t\u1ef1 do ho\u1eb7c k\u1ebft h\u1ee3p v\u1edbi ferritin v\u00e0 haemosiderin. T\u01b0\u01a1ng t\u1ef1, Deferoxamine t\u1ea1o ph\u1ee9c h\u1ee3p v\u1edbi nh\u00f4m li\u00ean k\u1ebft \u1edf m\u00f4. Deferoxamine l\u00e0m gi\u1ea3m \u1ee9 \u0111\u1ecdng s\u1eaft v\u00e0 nh\u00f4m \u1edf m\u00f4 v\u00e0 c\u00e1c c\u01a1 quan do th\u00fac \u0111\u1ea9y b\u00e0i ti\u1ebft hai ch\u1ea5t n\u00e0y qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 qua ph\u00e2n.<\/p>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n

H\u1ea5p thu
\nSau khi ti\u00eam b\u1eafp c\u1ea3 li\u1ec1u ho\u1eb7c truy\u1ec1n d\u01b0\u1edbi da ch\u1eadm, Deferoxamine \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh ch\u00f3ng. Khi ni\u00eam m\u1ea1c c\u00f2n nguy\u00ean v\u1eb9n th\u00ec l\u1ea1i k\u00e9m h\u1ea5p thu qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. Trong th\u1ea9m ph\u00e2n m\u00e0ng b\u1ee5ng, Deferoxamine d\u00f9ng trong dung d\u1ecbch th\u1ea9m ph\u00e2n s\u1ebd \u0111\u01b0\u1ee3c h\u1ea5p thu.<\/p>\n

Ph\u00e2n b\u1ed1
\n\u1ede ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh, sau 30 ph\u00fat ti\u00eam b\u1eafp li\u1ec1u 10 mg\/kg n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a Deferoxamine \u0111\u1ea1t 15,5 pmol\/L (87 pg\/mL).
\nSau ti\u00eam 1 gi\u1edd, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh \u0111\u1ea1t \u0111\u01b0\u1ee3c l\u00e0 3,7 micromol\/L , (2,3 pg\/mL).
\nCh\u1ec9 kho\u1ea3ng 10% Deferoxamine li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft thanh.<\/p>\n

Chuy\u1ec3n h\u00f3a
\n\u0110\u00e3 ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c 4 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a Deferoxamine t\u1eeb n\u01b0\u1edbc ti\u1ec3u.<\/p>\n

Th\u1ea3i tr\u1eeb
\nDeferoxamine v\u00e0 ferrioxamin c\u00f3 th\u1eddi gian b\u00e1n th\u1ea3i ph\u00e2n b\u1ed1 bi\u1ec3u ki\u1ebfn l\u1ea7n l\u01b0\u1ee3t l\u00e0 1 gi\u1edd; 2,4 gi\u1edd v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i cu\u1ed1i bi\u1ec3u ki\u1ebfn l\u00e0 6 gi\u1edd.
\nC\u00f3 22% li\u1ec1u d\u00f9ng xu\u1ea5t hi\u1ec7n trong n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng deferoxamine v\u00e0 1% d\u01b0\u1edbi d\u1ea1ng ferrioxamin trong v\u00f2ng 6 gi\u1edd sau khi ti\u00eam.<\/p>\n

Thu\u1ed1c Demoferidon 500mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n\n\n\n\n\n\n\n
Ch\u1ec9 \u0111\u1ecbnh<\/td>\nTr\u01b0\u1eddng h\u1ee3p c\u1ee5 th\u1ec3<\/td>\n<\/tr>\n
\u0110i\u1ec1u tr\u1ecb th\u1eeba s\u1eaft m\u1ea1n t\u00ednh<\/td>\nNhi\u1ec5m haemosiderin do truy\u1ec1n m\u00e1u \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n th\u01b0\u1eddng xuy\u00ean nh\u1eadn truy\u1ec1n m\u00e1u (ch\u1ee7 y\u1ebfu \u1edf b\u1ec7nh nh\u00e2n thalassaemia).
\nNhi\u1ec5m s\u1eafc t\u1ed1 s\u1eaft nguy\u00ean ph\u00e1t v\u00e0 th\u1ee9 ph\u00e1t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 c\u00e1c r\u1ed1i lo\u1ea1n \u0111\u1ed3ng th\u1eddi (nh\u01b0 thi\u1ebfu m\u00e1u n\u1eb7ng, gi\u1ea3m protein m\u00e1u, suy tim ho\u1eb7c suy th\u1eadn) ng\u0103n ng\u1eeba tr\u00edch m\u00e1u, t\u0129nh m\u1ea1ch.<\/td>\n<\/tr>\n
\u0110i\u1ec1u tr\u1ecb nhi\u1ec5m \u0111\u1ed9c s\u1eaft c\u1ea5p t\u00ednh<\/td>\n<\/tr>\n
\u0110i\u1ec1u tr\u1ecb th\u1eeba nh\u00f4m<\/td>\nTh\u1ea9m ph\u00e2n duy tr\u00ec trong suy th\u1eadn giai \u0111o\u1ea1n cu\u1ed1i khi c\u00e1c bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba (nh\u01b0 th\u1ea9m th\u1ea5u ng\u01b0\u1ee3c) th\u1ea5t b\u1ea1i.
\nB\u1ec7nh x\u01b0\u01a1ng li\u00ean quan \u0111\u1ebfn nh\u00f4m.
\nB\u1ec7nh n\u00e3o do th\u1ea9m ph\u00e2n.
\nThi\u1ebfu m\u00e1u li\u00ean quan \u0111\u1ebfn nh\u00f4m.<\/td>\n<\/tr>\n
Ch\u1ea9n \u0111o\u00e1n c\u00e1c b\u1ec7nh d\u1ef1 tr\u1eef s\u1eaft, th\u1eeba nh\u00f4m v\u00e0 c\u00e1c tr\u01b0\u1eddng h\u1ee3p thi\u1ebfu m\u00e1u.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Demoferidon 500mg<\/h2>\n

Thu\u1ed1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng qua \u0111\u01b0\u1eddng ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch ho\u1eb7c d\u01b0\u1edbi da. Kh\u00f4ng n\u00ean ti\u00eam v\u00e0o g\u1ea7n s\u00e1t ch\u00e2n bi khi d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam d\u01b0\u1edbi da.<\/p>\n

Th\u01b0\u1eddng d\u00f9ng d\u1ea1ng dung d\u1ecbch 10% b\u1eb1ng c\u00e1ch l\u1ea5y 500 mg b\u1ed9t thu\u1ed1c pha trong 5 ml n\u01b0\u1edbc pha ti\u00eam ( Natri clorid 0,9%, dung d\u1ecbch h\u1ed7n h\u1ee3p Natri clorid 0,9%, Dextrose 5% v\u00e0 Dextrose 5%, Ringer Lactat).<\/p>\n

\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c ngo\u1ea1i tr\u00fa ho\u1eb7c th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c \u0111\u1ecbnh k\u1ef3 c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng Deferoxamine d\u1ea1ng h\u00f2a tan c\u00f3 th\u1ec3 th\u00eam v\u00e0o dung d\u1ecbch th\u1ea9m ph\u00e2n.<\/p>\n

\u0110i\u1ec1u tr\u1ecb nhi\u1ec5m \u0111\u1ed9c s\u1eaft c\u1ea5p t\u00ednh \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em<\/h3>\n

C\u00e2n nh\u1eafc d\u00f9ng Deferoxamine ngo\u00e0i \u0111\u01b0\u1eddng ti\u00eau h\u00f3a trong nh\u1eefng t\u00ecnh hu\u1ed1ng sau:
\nB\u1ec7nh nh\u00e2n c\u00f3 nhi\u1ec1u h\u01a1n c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u1eb9 tho\u00e1ng qua (v\u00ed d\u1ee5 nhi\u1ec1u h\u01a1n m\u1ed9t giai \u0111o\u1ea1n n\u00f4n ho\u1eb7c \u0111i ngo\u00e0i ph\u00e2n m\u1ec1m).
\nB\u1ec7nh nh\u00e2n c\u00f3 hi\u1ec7n t\u01b0\u1ee3ng ng\u1ee7 l\u1ecbm, \u0111au b\u1ee5ng nhi\u1ec1u, th\u1ec3 t\u00edch m\u00e1u gi\u1ea3m, ho\u1eb7c nhi\u1ec5m acid.
\nB\u1ec7nh nh\u00e2n khi ch\u1ee5p X-quang b\u1ee5ng d\u01b0\u01a1ng t\u00ednh c\u00f3 nhi\u1ec1u s\u1ef1 c\u1ea3n tia X.
\nB\u1ec7nh nh\u00e2n c\u00f3 tri\u1ec7u ch\u1ee9ng v\u1edbi n\u1ed3ng \u0111\u1ed9 s\u1eaft huy\u1ebft thanh cao h\u01a1n 300 \u2013 350 pg\/dL.<\/p>\n

Li\u1ec1u d\u00f9ng:
\nTruy\u1ec1n t\u0129nh m\u1ea1ch li\u00ean t\u1ee5c v\u1edbi t\u1ed1c \u0111\u1ed9 truy\u1ec1n khuy\u1ebfn c\u00e1o l\u00e0 15 mg\/kg\/gi\u1edd. Gi\u1ea3m t\u1ed1c \u0111\u1ed9 khi c\u00f3 th\u1ec3, sao cho t\u1ed5ng li\u1ec1u truy\u1ec1n kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 80mg\/kg.<\/p>\n

C\u00e1ch d\u00f9ng:
\nD\u00f9ng b\u01a1m truy\u1ec1n d\u1ec5 mang, truy\u1ec1n d\u01b0\u1edbi da ch\u1eadm trong th\u1eddi gian 8-12 gi\u1edd \u0111\u01b0\u1ee3c xem l\u00e0 hi\u1ec7u qu\u1ea3 v\u00e0 thu\u1eadn ti\u1ec7n cho nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i l\u1ea1i \u0111\u01b0\u1ee3c, nh\u01b0ng c\u0169ng c\u00f3 th\u1ec3 truy\u1ec1n trong 24 gi\u1edd \u0111\u1ec3 t\u0103ng l\u01b0\u1ee3ng s\u1eaft b\u00e0i ti\u1ebft. T\u00f9y thu\u1ed9c v\u00e0o m\u1ee9c \u0111\u1ed9 th\u1eeba s\u1eaft b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb 5-7 l\u1ea7n\/tu\u1ea7n.
\nTruy\u1ec1n d\u01b0\u1edbi da c\u00f3 hi\u1ec7u qu\u1ea3 h\u01a1n \u0111\u01b0\u1eddng ti\u00eam b\u1eafp. Ngo\u00e0i ra, c\u00f3 th\u1ec3 truy\u1ec1n t\u0129nh m\u1ea1ch trong khi truy\u1ec1n m\u00e1u, tuy nhi\u00ean l\u1ee3i \u00edch l\u00e2m s\u00e0ng c\u1ee7a \u0111\u01b0\u1eddng d\u00f9ng n\u00e0y v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1. Kh\u00f4ng n\u00ean cho dung d\u1ecbch Deferoxamine v\u00e0o t\u00fai \u0111\u1ef1ng m\u00e1u m\u00e0 c\u00f3 th\u1ec3 cho v\u00e0o d\u00e2y truy\u1ec1n m\u00e1u. C\u1ea7n nh\u1eafc nh\u1edf b\u1ec7nh nh\u00e2n v\u00e0 y t\u00e1 \u0111\u1ec3 tr\u00e1nh truy\u1ec1n nhanh.
\nTruy\u1ec1n t\u0129nh m\u1ea1ch li\u00ean t\u1ee5c \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng th\u1ec3 ti\u1ebfp t\u1ee5c truy\u1ec1n d\u01b0\u1edbi da v\u00e0 cho nh\u1eefng ng\u01b0\u1eddi c\u00f3 c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 tim ,th\u1ee9 ph\u00e1t do th\u1eeba s\u1eaft. Khi c\u1ea7n chel\u1ea1t h\u00f3a m\u1ea1nh n\u00ean \u0111o th\u01b0\u1eddng xuy\u00ean l\u01b0\u1ee3ng s\u1eaft b\u00e0i ti\u1ebft trong n\u01b0\u1edbc ti\u1ec3u trong 24 gi\u1edd (\u0111\u1ef1\u1eddng t\u0129nh m\u1ea1ch) v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u t\u01b0\u01a1ng \u1ee9ng.
\nR\u1eeda s\u1ea1ch d\u00e2y truy\u1ec1n, tr\u00e1nh truy\u1ec1n \u0111\u1ed9t ng\u1ed9t l\u01b0\u1ee3ng Deferoxamine c\u00f2n s\u00f3t l\u1ea1i trong kho\u1ea3ng kh\u00f4ng d\u00f9ng c\u1ee7a d\u00e2y truy\u1ec1n.<\/p>\n

Ch\u1ea9n \u0111o\u00e1n b\u1ec7nh d\u1ef1 tr\u1eef s\u1eaft v\u00e0 c\u00e1c tr\u01b0\u1eddng h\u1ee3p thi\u1ebfu m\u00e1u<\/h3>\n

Ti\u00eam b\u1eafp Deferoxamine 500 mg. Trong 6 gi\u1edd sau, l\u1ea5y n\u01b0\u1edbc ti\u1ec3u v\u00e0 x\u00e1c \u0111\u1ecbnh h\u00e0m l\u01b0\u1ee3ng s\u1eaft. X\u00e1c \u0111\u1ecbnh th\u1eeba s\u1eaft khi l\u01b0\u1ee3ng s\u1eaft b\u00e0i ti\u1ebft t\u1eeb 1 -1,5 mg (18-27 micromol) trong th\u1eddi gian 6 gi\u1edd. N\u1ebfu gi\u00e1 tr\u1ecb n\u00e0y l\u1edbn h\u01a1n 1,5 mg (27 pmol) c\u00f3 th\u1ec3 xem nh\u01b0 b\u1ec7nh l\u00fd.<\/p>\n

\u0110i\u1ec1u tr\u1ecb th\u1eeba nh\u00f4m \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn giai \u0111o\u1ea1n cu\u1ed1i<\/h3>\n

N\u00ean \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Deferoxamine 500 mg khi:<\/p>\n