C\u00f4ng th\u1ee9c: M\u1ed7i vi\u00ean ch\u1ee9a:<\/p>\n
Mirtazapin \u2022\u2022\u2022\u2022\u2022\u2022 30 mg<\/p>\n
T\u00e1 d\u01b0\u1ee3c : Lactose, Avicel 102, Tinh b\u1ed9t b\u1eafp, PVP K30, Natri lauryl sulfat, Primellose, Aerosil 200, Magnesium stearate, HPMC 615, PEG 6000, Titan dioxyd, Talc, s\u1eaft oxyd \u0111\u1ecf, s\u1eaft oxit v\u00e0ng.<\/p>\n
H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean.<\/p>\n
Mirtazapin \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng sau kho\u1ea3ng 2 gi\u1edd.<\/p>\n
Kho\u1ea3ng 85% Mirtazapin g\u1eafn V\u1edaI protein huy\u1ebft t\u01b0\u01a1ng. Mirtazapin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a r\u1ed9ng r\u00e3i \u1edf gan v\u00e0 s\u1ef1 bi\u1ebfn \u0111\u1ed5i sinh h\u1ecdc ch\u1ee7 y\u1ebfu l\u00e0 kh\u1eed – methyl v\u00e0 oxy – h\u00f3a, ti\u1ebfp theo l\u00e0 ph\u1ea3n \u1ee9ng li\u00ean h\u1ee3p, enzym cytochrom P450 c\u00f3 li\u00ean quan l\u00e0 CYP2D6, CYp1A2 v\u00e0 c Y P3 A4.<\/p>\n
C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \/V-desmethyl c\u00f3 ho\u1ea1t t\u00ednh.<\/p>\n
Th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u (75%) v\u00e0 ph\u00e2n (15%). Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh t\u1eeb 20 – 40 gi\u1edd. D\u1eef li\u1ec7u t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ed9ng v\u1eadt ch\u1ec9 ra r\u1eb1ng Mirtazapin qua nhau thai. Mirtazapin ph\u00e2n b\u1ed1 v\u00e0o s\u1eefa m\u1eb9.<\/p>\n
Mirtazapine l\u00e0 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m 4 v\u00f2ng v\u00e0 l\u00e0 d\u1eabn ch\u1ea5t c\u1ee7a piperazine ion c\u00f3 c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc kh\u00e1c v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m 3 v\u00f2ng, c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf’ monoamine oxidase v\u00e0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf’ ch\u1ecdn l\u1ecdc t\u00e1i thu h\u1ed3i serotonin.<\/p>\n
Mirtazapine l\u00e0 m\u1ed9t thu\u1ed1c \u0111\u1ed1i kh\u00e1ng Oj ti\u1ec1n xinap c\u00f3 ho\u1ea1t t\u00ednh trung \u01b0\u01a1ng, l\u00e0m t\u0103ng d\u1eabn truy\u1ec1n th\u1ea7n kinh qua trung gian noradrenalin v\u00e0 serotonin trung \u01b0\u01a1ng. S\u1ef1 t\u0103ng c\u01b0\u1eddng d\u1eabn truy\u1ec1n th\u1ea7n kinh qua trung gian serotonin ch\u1ec9 th\u00f4ng qua c\u00e1c th\u1ee5 th\u1ec3 5-HT, \u0111\u1eb7c hi\u1ec7u, b\u1edfi v\u00ec c\u00e1c th\u1ee5 th\u1ec3 5-HT2 v\u00e0 5-HT 3 b\u1ecb ch\u1eb7n b\u1edfi Mirtazapine. C\u1ea3 hai ch\u1ea5t \u0111\u1ed3ng ph\u00e2n \u0111\u1ed1i quang c\u1ee7a Mirtazapin \u0111\u1ec1u \u0111\u01b0\u1ee3c cho l\u00e0 tham gia v\u00e0o ho\u1ea1t t\u00ednh ch\u1ed1ng tr\u1ea7m c\u1ea3m, \u0111\u1ed3ng ph\u00e2n \u0111\u1ed1i \u1ea3nh s (+) ch\u1eb9n th\u1ee5 th\u1ec3 \u01a02 v\u00e0 5-HT2, v\u00e0 \u0111\u1ed3ng ph\u00e2n \u0111\u1ed1i \u1ea3nh R (-) ch\u1eb9n th\u1ee5 th\u1ec3 5-HT,.<\/p>\n
Ho\u1ea1t t\u00ednh \u0111\u1ed1i kh\u00e1ng histamin H, c\u1ee7a Mirtazapin c\u1ecf li\u00ean quan \u0111\u1ebfn t\u00ednh ch\u1ea5t an th\u1ea7n c\u1ee7a thu\u1ed1c. Mirtazapin th\u01b0\u1eddng \u0111\u01b0\u1ee3c dung n\u1ea1p r\u1ea5t t\u1ed1t. Thu\u1ed1c h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng cholinergic, v\u00e0 v\u1edbi li\u1ec1u \u0111i\u1ec1u tr\u1ecb h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng tr\u00ean h\u1ec7 tim m\u1ea1ch.<\/p>\n
B\u1ec7nh tr\u1ea7m c\u1ea3m.<\/p>\n
Qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi Mirtazapine v\u00e0 v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n
Ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf’ MAO c\u00f3 nguy c\u01a1 h\u1ed9i ch\u1ee9ng serotonin.<\/p>\n
C\u00e1ch d\u00f9ng: Mirtazapine \u0111\u01b0\u1ee3c d\u00f9ng qua \u0111\u01b0\u1eddng u\u1ed1ng, li\u1ec1u d\u00f9ng trong ng\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng 1 l\u1ea7n tr\u01b0\u1edbc khi \u0111i ng\u1ee7 ho\u1eb7c chia l\u00e0m 2 l\u1ea7n (1 l\u1ea7n bu\u1ed5i s\u00e1ng, 1 l\u1ea7n li\u1ec1u cao bu\u1ed5i t\u1ed1i tr\u01b0\u1edbc khi \u0111i ng\u1ee7). C\u00f3 th\u1ec3 d\u00f9ng thu\u1ed1c c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/p>\n
Li\u1ec1u d\u00f9ng cho ng\u01b0\u1eddi\/l\u1edbn \u0110i\u1ec1u tr\u1ecb b\u1ec7nh tr\u1ea7m c\u1ea3m n\u1eb7ng. Li\u1ec1u kh\u1edfi \u0111\u1ea7u 15mg\/ng\u00e0y, n\u1ebfu kh\u00f4ng c\u00f3 \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng r\u00f5 c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u t\u1ed1i \u0111a 45 mg, v\u1edbi kho\u1ea3ng c\u00e1ch \u00edt nh\u1ea5t 1 – 2 tu\u1ea7n gi\u1eefa c\u00e1c l\u1ea7n thay \u0111\u1ed5i ki\u1ec3u do n\u1eeda \u0111\u1eddi th\u1ea3i tr\u1eeb c\u1ee7a thu\u1ed1c d\u00e0i. Th\u1eddi gian t\u1ed1i \u01b0u \u0111i\u1ec1u tr\u1ecb duy tr\u00ec thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh r\u00f5. c\u1ea7n duy tr\u00ec \u0111i\u1ec1u tr\u1ecb \u00edt nh\u1ea5t 6 th\u00e1ng \u0111\u1ed1i v\u1edbi m\u1ed9t \u0111\u1ee3t tr\u1ea7m c\u1ea3m c\u1ea5p.<\/p>\n
C\u1ea7n gi\u1ea3m li\u1ec1u t\u1eeb t\u1eeb mirtazapin tr\u01b0\u1edbc khi ng\u1eebng thu\u1ed1c \u0111\u1ec3 tr\u00e1nh h\u1ed9i ch\u1ee9ng cai thu\u1ed1c. Ng\u01b0\u1eddi cao tu\u1ed5i: Kh\u00f4ng c\u1ea9n hi\u1ec7u ch\u1ec9nh li\u1ec1u, tuy v\u1eady c\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng thu\u1ed1c. Suy gan, suy th\u1eadn: c\u1ea7n c\u00e2n nh\u1eafc gi\u1ea3m li\u1ec1u cho b\u1ec7nh nh\u00e2n suy gan (\u0111\u1ed9 thanh th\u1ea3i c\u1ee7a mirtazapin gi\u1ea3m 30%) v\u00e0 b\u1ec7nh nh\u00e2n suy th\u00e2n (\u0111\u00f4 thanh th\u1ea3i c\u1ee7a mirtazapin gi\u1ea3m t\u1eeb 30 – 50%).<\/p>\n
B\u1ec7nh nh\u00e2n tr\u1ea7m c\u1ea3m c\u00f3 m\u1ed9t s\u1ed1’ tri\u1ec7u ch\u1ee9ng hay \u0111i k\u00e8m v\u1edbi b\u1ec7nh. Do v\u1eady \u0111\u00f4i khi r\u1ea5t kh\u00f3 ch\u1eafc ch\u1eafn \u0111\u01b0\u1ee3c tri\u1ec7u ch\u1ee9ng n\u00e0o l\u00e0 h\u1eadu qu\u1ea3 c\u1ee7a b\u1ec7nh v\u00e0 tri\u1ec7u ch\u1ee9ng n\u00e0o l\u00e0 h\u1eadu qu\u1ea3 c\u1ee7a \u0111i\u1ec1u tr\u1ecb thu\u1ed1c. C\u00e1c t\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd th\u01b0\u1eddng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o nh\u1ea5t khi \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c l\u00e0: Kh\u00f4 mi\u1ec7ng, ch\u00f3ng m\u1eb7t, m\u1ec7t m\u1ecfi.<\/p>\n
Bu\u1ed3n ng\u1ee7\/ an th\u1ea7n, th\u01b0\u1eddng x\u1ea3y ra trong \u00edt tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb (Ghi ch\u00fa : gi\u1ea3m li\u1ec1u th\u01b0\u1eddng kh\u00f4ng gi\u1ea3m t\u00e1c d\u1ee5ng an th\u1ea7n m\u00e0 l\u1ea1i c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u l\u1ef1c ch\u1ed1ng tr\u1ea7m c\u1ea3m).<\/p>\n
Trong m\u1ed9t s\u1ed1 hi\u1ebfm tr\u01b0\u1eddng h\u1ee3p, c\u00f3 th\u1ec3 x\u1ea3y ra nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 sau \u0111\u00e2y:<\/p>\n
\u1ee8c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng, th\u01b0\u1eddng \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n b\u1eb1ng gi\u1ea3m ho\u1eb7c m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong khi \u0111i\u1ec1u tr\u1ecb v\u1edbi \u0111a s\u1ed1 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m. Tai bi\u1ebfn n\u00e0y ph\u1ea7n l\u1edbn x\u1ea3y ra sau 4-6 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb v\u00e0 th\u01b0\u1eddng h\u1ed3i ph\u1ee5c khi ng\u01b0ng \u0111i\u1ec1u tr\u1ecb. M\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t c\u00f3 th\u1ec3 ph\u1ee5c h\u1ed3i c\u0169ng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o nh\u01b0 l\u00e0 m\u1ed9t t\u00ecnh hu\u1ed1ng hi\u1ebfm g\u1eb7p trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u1edbi thu\u1ed1c.<\/p>\n
Ph\u1ea3i b\u00e1o c\u00e1o v\u1edbi th\u1ea7y thu\u1ed1c v\u1ec1 nh\u1eefng tri\u1ec7u ch\u1ee9ng nh\u01b0 s\u1ed1t, \u0111au h\u1ecdng, vi\u00eam mi\u1ec7ng ho\u1eb7c nh\u1eefng nhi\u1ec5m tr\u00f9ng kh\u00e1c; khi x\u1ea3y ra nh\u1eefng tri\u1ec7u ch\u1ee9ng nh\u01b0 v\u1eady n\u00ean ng\u01b0ng \u0111i\u1ec1u tr\u1ecb v\u00e0 npn YPt nhipm m\u00e1 II<\/p>\n
C\u1ea7n d\u00f9ng thu\u1ed1c c\u1ea9n th\u1eadn c\u0169ng nh\u01b0 g\u1ea7n \u0111\u1ec1u \u0111\u1eb7n theo d\u00f5i s\u00e1t \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh n a n co \u0110\u1ed9ng kinh v\u00e0 h\u1ed9i ch\u1ee9ng n\u00e3o th\u1ef1c th\u1ec3; kinh nghi\u1ec7m l\u00e2m s\u00e0ng cho th\u1ea5y nh\u1eefng ton th\u01b0\u01a1ng n\u00e0y hi\u1ebfm khi x\u1ea3y ra tr\u00ean b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c.<\/p>\n
Suy gan ho\u1eb7c suy th\u1eadn.<\/p>\n
B\u1ec7nh tim nh\u01b0 r\u1ed1i lo\u1ea1n d\u1eabn truy\u1ec1n, \u0111au th\u1eaft ng\u1ef1c v\u00e0 nh\u1ed3i m\u00e1u c\u01a1 tim m\u1edbi, v\u1ed1n l\u00e0 nh\u1eefng tr\u01b0\u1eddng h\u1ee3p th\u01b0\u1eddng ph\u1ea3i th\u1eadn tr\u1ecdng v\u00e0 c\u1ea9n th\u1eadn khi d\u00f9ng chung v\u1edbi nh\u1eefng thu\u1ed1c kh\u00e1c. Huy\u1ebft \u00e1p th\u1ea5p.<\/p>\n
C\u0169ng nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00e1c, c\u1ea7n th\u1eadn tr\u1ecdng \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n:<\/p>\n
R\u1ed1i lo\u1ea1n ti\u1ec3u ti\u1ec7n nh\u01b0 ph\u00ec \u0111\u1ea1i tuy\u1ebfn ti\u1ec1n li\u1ec7t (truy v\u1ea5n \u0111\u1ec3 n\u00e0y \u00edt g\u1eb7p vl thu\u1ed1c ch\u1ec9 c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng cholinergic r\u1ea5t y\u1ebfu).<\/p>\n
Glaucom g\u00f3c h\u1eb9p c\u1ea5p v\u00e0 t\u0103ng nh\u00e3n \u00e1p (v\u1ea5n \u0111\u1ec3 n\u00e0y c\u0169ng \u00edt c\u00f3 c\u01a1 h\u1ed9i x\u1ea3y ra, vl ho\u1ea1t t\u00ednh kh\u00e1ng cholinergic c\u1ee7a thu\u1ed1c r\u1ea5t y\u1ebfu).
\n\u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n
N\u00ean ng\u01b0ng \u0111i\u1ec1u tr\u1ecb n\u1ebfu x\u1ea3y ra v\u00e0ng da.<\/p>\n
Ngo\u00e0i ra nh\u01b0 \u0111\u1ed1i v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00e1c, c\u0169ng c\u1ea7n l\u01b0u \u00fd \u0111\u1ebfn:<\/p>\n
Tri\u1ec7u ch\u1ee9ng t\u00e2m th\u1ea7n c\u00f3 th\u1ec3 di\u1ec5n bi\u1ebfn x\u1ea5u h\u01a1n khi d\u00f9ng thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m cho b\u1ec7nh nh\u00e2n t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t ho\u1eb7c c\u00e1c r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n kh\u00e1c : \u00fd ngh\u0129 hoang t\u01b0\u1edfng b\u1ed9 ph\u1eadn (paranoid) c\u00f3 th\u1ec3 tr\u1ea7m tr\u1ecdng h\u01a1n.<\/p>\n
Khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb trong giai \u0111o\u1ea1n tr\u1ea7m c\u1ea3m c\u1ee7a b\u1ec7nh lo\u1ea1n th\u1ea7n h\u01b0ng – tr\u1ea7m c\u1ea3m, b\u1ec7nh c\u00f3 th\u1ec3 chuy\u1ec3n sang giai \u0111o\u1ea1n h\u01b0ng c\u1ea3m.
\nv\u1ec1 nguy c\u01a1 t\u1ef1 t\u1eed, \u0111\u1eb7c bi\u1ec7t l\u00e0 khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, ch\u1ec9 n\u00ean cho b\u1ec7nh nh\u00e2n d\u00f9ng \u00edt thu\u1ed1c.<\/p>\n
Tuy thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00f4ng g\u00e2y nghi\u1ec7n, nh\u01b0ng n\u1ebfu ng\u01b0ng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t sau m\u1ed9t th\u1eddi gian d\u00e0i d\u00f9ng thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y bu\u1ed3n n\u00f4n, nh\u1ee9c \u0111\u1ea7u v\u00e0 kh\u00f3 \u1edf.<\/p>\n
B\u1ec7nh nh\u00e2n cao tu\u1ed5i th\u01b0\u1eddng nh\u1ea1y c\u1ea3m h\u01a1n, \u0111\u1eb7c bi\u1ec7t v\u1edbi c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m. Trong nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u1edbi thu\u1ed1c, tr\u00ean b\u1ec7nh nh\u00e2n cao tu\u1ed5i kh\u00f4ng th\u1ea5y t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o nhi\u1ec1u h\u01a1n so v\u1edbi c\u00e1c nh\u00f3m tu\u1ed5i kh\u00e1c; tuy v\u1eady cho \u0111\u1ebfn nay v\u1eabn c\u00f2n \u00edt kinh nghi\u1ec7m v\u1ec1 v\u1ea5n \u0111\u1ec1 n\u00e0y.<\/p>\n
T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c khi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c:<\/p>\n
Thu\u1ed1c c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng t\u1eadp trung v\u00e0 s\u1ef1 t\u1ec9nh t\u00e1o. B\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi nh\u1eefng thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m n\u00ean tr\u00e1nh l\u00e0m nh\u1eefng c\u00f4ng vi\u1ec7c c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y nguy hi\u1ec3m c\u1ea7n s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 t\u1eadp trung t\u1ed1t nh\u01b0 l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n
Mirtazapin c\u00f3 th\u1ec3 t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng c\u1ee7a r\u01b0\u1ee3u, do \u0111\u00f3 n\u00ean khuy\u00ean b\u1ec7nh nh\u00e2n ki\u00eang r\u01b0\u1ee3u trong khi \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c.<\/p>\n
Kh\u00f4ng n\u00ean d\u00f9ng Mirtazapine \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf MAO ho\u1eb7c trong v\u00f2ng 2 tu\u1ea7n sau khi ng\u01b0ng \u0111i\u1ec1u tr\u1ecb v\u1edbi nh\u1eefng thu\u1ed1c n\u00e0y.<\/p>\n
Mirtazapin c\u00f3 th\u1ec3 t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng an th\u1ea7n c\u1ee7a benzodiazepin; c\u1ea7n th\u1eadn tr\u1ecdng khi k\u00ea toa nh\u1eefng thu\u1ed1c n\u00e0y c\u00f9ng v\u1edbi Mirtazapine.<\/p>\n
V\u1edbi tramadol, olanzapin, fluoxetin, fluvoxamin, procarbazin (nguy c\u01a1 xu\u1ea5t hi\u1ec7n h\u1ed9i ch\u1ee9ng serotonin v\u1edbi bi\u1ec3u hi\u1ec7n s\u1ed1t cao, t\u0103ng ph\u1ea3n x\u1ea1, gi\u1eadt c\u01a1, bi\u1ebfn \u0111\u1ed5i tr\u1ea1ng th\u00e1i t\u00e2m tr\u00ed), v\u1edbi diazepam (\u1ee9c ch\u1ebf k\u1ef9 n\u0103ng v\u1eadn \u0111\u1ed9ng).<\/p>\n
V\u1edbi c\u00e1c thu\u1ed1c c\u1ea3m \u1ee9ng enzym chuy\u1ec3n h\u00f3a thu\u1ed1c nh\u01b0 carbamazepin, phenytoin (l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 trong m\u00e1u d\u1eabn \u0111\u1ebfn gi\u1ea3m hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a mirtazapin).<\/p>\n
V\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf enzym chuy\u1ec3n h\u00f3a thu\u1ed1c CYP3A4, CYP2D6 v\u00e0 CYP1A2 (cimetidin, c\u00e1c d\u1eabn ch\u1ea5t azol ch\u1ed1ng n\u1ea5m, c\u00e1c thu\u1ed1c kh\u00e1ng protease c\u1ee7a virus HIV, erythromycin (l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 trong m\u00e1u v\u00e0 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a mirtazapin). S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 \u0111ang cho con b\u00fa:<\/p>\n
Th\u1eddi k\u1ef3 mang thai: M\u1eb7c d\u00f9 nh\u1eefng nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng cho th\u1ea5y t\u00e1c d\u1ee5ng sinh qu\u00e1i thai c\u00f3 \u00fd ngh\u0129a \u0111\u1ed9c t\u00ednh, \u0111\u1ed9 an to\u00e0n c\u1ee7a thu\u1ed1c tr\u00ean thai ng\u01b0\u1eddi v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c ch\u1ee9ng minh. Ch\u1ec9 n\u00ean d\u00f9ng thu\u1ed1c trong khi c\u00f3 thai n\u1ebfu th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft. Ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai n\u00ean \u00e1p d\u1ee5ng m\u1ed9t bi\u1ec7n ph\u00e1p tr\u00e1nh thai h\u1eefu hi\u1ec7u n\u1ebfu \u0111ang u\u1ed1ng thu\u1ed1c.<\/p>\n
Th\u1eddi k\u1ef3 cho con b\u00fa .’Mirtazapin \u0111\u01b0\u1ee3c b\u00e0i xu\u1ea5t v\u1edbi m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf v\u00e0o s\u1eefa v\u00e0 c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n cho tr\u1ebb \u0111ang b\u00fa sau m\u1ed9t th\u1eddi gian d\u00e0i ph\u01a1i nhi\u1ec5m v\u1edbi thu\u1ed1c. V\u00ec v\u1eady c\u1ea7n h\u1ebft s\u1ee9c th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng mirtazapine cho ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n
\u0110\u1ed9 an to\u00e0n c\u1ee7a thu\u1ed1c sau khi d\u00f9ng qu\u00e1 li\u1ec1u ch\u01b0a \u0111\u01b0\u1ee3c ch\u1ee9ng minh. Nh\u1eefng nghi\u00ean c\u1ee9u \u0111\u1ed9c t\u00ednh \u0111\u00e3 ch\u1ee9ng minh kh\u00f4ng x\u1ea3y ra c\u00e1c t\u00e1c d\u1ee5ng \u0111\u1ed9c tim c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng sau khi d\u00f9ng thu\u1ed1c qu\u00e1 li\u1ec1u. Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi thu\u1ed1c, ngo\u00e0i t\u00e1c d\u1ee5ng an th\u1ea7n th\u00e1i qu\u00e1, kh\u00f4ng ghi nh\u1eadn \u0111\u01b0\u1ee3c nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0o c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng sau khi d\u00f9ng qu\u00e1 li\u1ec1u. C\u00e1c tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u c\u1ea7n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1ch r\u1eeda d\u1ea1 d\u00e0y k\u00e8m v\u1edbi \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 n\u00e2ng \u0111\u1ee1 th\u00edch h\u1ee3p \u0111\u1ed1i v\u1edbi c\u00e1c ch\u1ee9c n\u0103ng sinh t\u1ed3n.<\/p>\n
B\u1ea3o qu\u1ea3n : N\u01a1i kh\u00f4 m\u00e1t (d\u01b0\u1edbi 30\u00b0C), tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n
Thu\u1ed1c s\u1ea3n xu\u1ea5t theo USP 38<\/p>\n
H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng k\u1ec3 t\u1eeb ng\u00e0y s\u1ea3n xu\u1ea5t.<\/p>\n","protected":false},"excerpt":{"rendered":"
Futaton C\u00f4ng th\u1ee9c: M\u1ed7i vi\u00ean ch\u1ee9a: Mirtazapin \u2022\u2022\u2022\u2022\u2022\u2022 30 mg T\u00e1 d\u01b0\u1ee3c : Lactose, Avicel 102, Tinh b\u1ed9t b\u1eafp, PVP K30, Natri lauryl sulfat, Primellose, Aerosil 200, Magnesium stearate, HPMC 615, PEG 6000, Titan dioxyd, Talc, s\u1eaft oxyd \u0111\u1ecf, s\u1eaft oxit v\u00e0ng. Tr\u00ecnh b\u00e0y: H\u1ed9p 10 v\u1ec9 x 10 vi\u00ean. D\u01af\u1ee2C \u0111\u1ed9ng h\u1ecdc: Mirtazapin \u0111\u01b0\u1ee3c […]\n","protected":false},"author":1,"featured_media":33724,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[90],"product_tag":[],"class_list":{"0":"post-33720","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuc-pham-chuc-nang","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product\/33720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/comments?post=33720"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media\/33724"}],"wp:attachment":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media?parent=33720"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_cat?post=33720"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_tag?post=33720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}