{"id":158186,"date":"2026-05-29T09:58:37","date_gmt":"2026-05-29T02:58:37","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=158186"},"modified":"2026-05-29T10:00:59","modified_gmt":"2026-05-29T03:00:59","slug":"zustafa-40mg","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/zustafa-40mg\/","title":{"rendered":"Zustafa 40mg"},"content":{"rendered":"
Trong b\u00e0i vi\u1ebft n\u00e0y,<\/b> d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/b><\/a> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Zustafa 40mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m v\u00e0 sinh h\u1ecdc y t\u1ebf c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110460023<\/b><\/p>\n Trong m\u1ed7i vi\u00ean u\u1ed1ng Zustafa 40mg <\/b>c\u00f3 ch\u1ee9a:<\/p>\n D\u1ea1ng b\u00e0o ch\u1ebf: Thu\u1ed1c b\u1ed9t pha h\u1ed7n d\u1ecbch<\/p>\n S\u0110K: 893110460023<\/p>\n Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 30 g\u00f3i x 3g<\/p>\n Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n Omeprazole l\u00e0 ho\u1ea1t ch\u1ea5t ch\u1ed1ng b\u00e0i ti\u1ebft axit d\u1ea1 d\u00e0y thu\u1ed9c d\u1eabn xu\u1ea5t benzimidazole c\u1ea5u tr\u00fac th\u1ebf. Thu\u1ed1c th\u1ec3 hi\u1ec7n t\u00e1c d\u1ee5ng th\u00f4ng qua c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf \u0111\u1eb7c hi\u1ec7u v\u00e0 c\u00f3 ch\u1ecdn l\u1ecdc h\u1ec7 th\u1ed1ng enzyme H+\/K+ ATPase \u2013 hay c\u00f2n g\u1ecdi l\u00e0 b\u01a1m proton \u2013 t\u1ea1i m\u00e0ng ti\u1ebft c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y.<\/p>\n Qu\u00e1 tr\u00ecnh \u1ee9c ch\u1ebf n\u00e0y c\u00f3 li\u00ean quan tr\u1ef1c ti\u1ebfp \u0111\u1ebfn li\u1ec1u d\u00f9ng, gi\u00fap k\u00ecm h\u00e3m s\u1ef1 ti\u1ebft d\u1ecbch v\u1ecb t\u1ea1i d\u1ea1 d\u00e0y. Ho\u1ea1t ch\u1ea5t kh\u00f4ng \u0111\u1ed3ng th\u1eddi th\u1ec3 hi\u1ec7n \u0111\u1eb7c t\u00ednh kh\u00e1ng th\u1ee5 th\u1ec3 histamine H2 ho\u1eb7c kh\u00e1ng cholinergic.<\/p>\n Do \u0111\u1eb7c t\u00ednh k\u00e9m b\u1ec1n v\u00e0 nhanh ch\u00f3ng b\u1ecb ph\u00e2n h\u1ee7y trong m\u00f4i tr\u01b0\u1eddng acid d\u1ecbch v\u1ecb, thu\u1ed1c ph\u1ed1i h\u1ee3p th\u00ean th\u00e0nh ph\u1ea7n Natri bicarbonate. S\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a ch\u1ea5t ki\u1ec1m n\u00e0y \u0111\u00f3ng vai tr\u00f2 trung h\u00f2a v\u00e0 n\u00e2ng cao ch\u1ec9 s\u1ed1 pH d\u1ea1 d\u00e0y, t\u1ea1o m\u00e0ng b\u1ecdc b\u1ea3o v\u1ec7 t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a c\u1ea5u tr\u00fac Omeprazole, t\u1eeb \u0111\u00f3 gi\u00fap ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng t\u1ee9c th\u1eddi \u0111\u1ec3 ph\u00e1t huy t\u1ed1i \u0111a hi\u1ec7u n\u0103ng \u0111i\u1ec1u tr\u1ecb.<\/p>\n H\u1ea5p thu: Qu\u00e1 tr\u00ecnh h\u1ea5p thu omeprazol di\u1ec5n ra nhanh ch\u00f3ng khi ng\u01b0\u1eddi b\u1ec7nh s\u1eed d\u1ee5ng d\u1ea1ng h\u1ed7n d\u1ecbch u\u1ed1ng l\u00fac d\u1ea1 d\u00e0y tr\u1ed1ng (t\u1ed1i thi\u1ec3u 1 gi\u1edd tr\u01b0\u1edbc b\u1eefa \u0103n). Sau khi d\u00f9ng li\u1ec1u \u0111\u01a1n ho\u1eb7c li\u1ec1u l\u1eb7p l\u1ea1i, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trung b\u00ecnh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t kho\u1ea3ng 1954 ng\/ml, v\u1edbi th\u1eddi gian \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a x\u1ea5p x\u1ec9 30 ph\u00fat (bi\u1ebfn thi\u00ean trong kho\u1ea3ng 10 – 90 ph\u00fat). Do x\u1ea3y ra qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a b\u01b0\u1edbc \u0111\u1ea7u qua gan m\u1ea1nh tr\u01b0\u1edbc khi v\u00e0o tu\u1ea7n ho\u00e0n h\u1ec7 th\u1ed1ng, sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i c\u1ee7a thu\u1ed1c ghi nh\u1eadn trong kho\u1ea3ng 30 – 40%. Di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong (AUC) c\u1ee7a omeprazol t\u1ec9 l\u1ec7 thu\u1eadn v\u1edbi m\u1ee9c li\u1ec1u trong kho\u1ea3ng 20 – 40 mg. Tuy nhi\u00ean, khi t\u0103ng li\u1ec1u l\u00ean g\u1ea5p \u0111\u00f4i (m\u1ee9c 40 mg), ch\u1ec9 s\u1ed1 AUC trung b\u00ecnh t\u0103ng v\u01b0\u1ee3t tr\u1ed9i (g\u1ea5p 2 l\u1ea7n). \u0110\u1ed3ng th\u1eddi, sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c c\u00f3 xu h\u01b0\u1edbng t\u0103ng l\u00ean sau c\u00e1c li\u1ec1u d\u00f9ng l\u1eb7p l\u1ea1i. Ng\u01b0\u1ee3c l\u1ea1i, n\u1ebfu u\u1ed1ng thu\u1ed1c v\u00e0o th\u1eddi \u0111i\u1ec3m 1 gi\u1edd sau khi \u0103n, gi\u00e1 tr\u1ecb AUC b\u1ecb suy gi\u1ea3m kho\u1ea3ng 24% so v\u1edbi khi u\u1ed1ng l\u00fac \u0111\u00f3i.<\/p>\n Ph\u00e2n b\u1ed1: Kh\u1ea3 n\u0103ng li\u00ean k\u1ebft c\u1ee7a omeprazol v\u1edbi c\u00e1c protein huy\u1ebft t\u01b0\u01a1ng \u1edf m\u1ee9c cao, ~95%.<\/p>\n Chuy\u1ec3n h\u00f3a: Ph\u1ea7n l\u1edbn li\u1ec1u d\u00f9ng (x\u1ea5p x\u1ec9 77%) \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a (\u00edt nh\u1ea5t 6 ch\u1ea5t \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh). C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a n\u00e0y h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 ho\u1eb7c ch\u1ec9 c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng ti\u1ebft axit \u1edf m\u1ee9c r\u1ea5t th\u1ea5p. L\u01b0\u1ee3ng thu\u1ed1c c\u00f2n l\u1ea1i \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft nguy\u00ean v\u1eb9n ho\u1eb7c d\u01b0\u1edbi d\u1ea1ng chuy\u1ec3n h\u00f3a qua ph\u00e2n.<\/p>\n Th\u1ea3i tr\u1eeb: H\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 ho\u1eb7c c\u00f3 r\u1ea5t \u00edt l\u01b0\u1ee3ng ho\u1ea1t ch\u1ea5t g\u1ed1c ch\u01b0a bi\u1ebfn \u0111\u1ed5i xu\u1ea5t hi\u1ec7n trong n\u01b0\u1edbc ti\u1ec3u. \u1ede nh\u1eefng c\u00e1 th\u1ec3 kh\u1ecfe m\u1ea1nh, th\u1eddi gian b\u00e1n th\u1ea3i t1\/2 trung b\u00ecnh c\u1ee7a omeprazol trong huy\u1ebft t\u01b0\u01a1ng r\u01a1i v\u00e0o kho\u1ea3ng 1 gi\u1edd (dao \u0111\u1ed9ng t\u1eeb 0,4 \u0111\u1ebfn 3,2 gi\u1edd). H\u1ec7 s\u1ed1 thanh th\u1ea3i to\u00e0n th\u00e2n c\u1ee7a thu\u1ed1c \u0111\u1ea1t m\u1ee9c 500 – 600 ml\/ph\u00fat.<\/p>\n Lo\u00e9t t\u00e1 tr\u00e0ng: \u0110i\u1ec1u tr\u1ecb ng\u1eafn h\u1ea1n c\u00e1c t\u00ecnh tr\u1ea1ng lo\u00e9t ti\u1ebfn tri\u1ec3n \u1edf h\u00e0nh t\u00e1 tr\u00e0ng (th\u1eddi gian \u00e1p d\u1ee5ng t\u1eeb 4 \u0111\u1ebfn 8 tu\u1ea7n).<\/p>\n Lo\u00e9t d\u1ea1 d\u00e0y l\u00e0nh t\u00ednh: Tr\u1ecb li\u1ec7u ng\u1eafn h\u1ea1n cho b\u1ec7nh nh\u00e2n m\u1eafc lo\u00e9t d\u1ea1 d\u00e0y th\u1ec3 l\u00e0nh t\u00ednh (th\u1eddi gian k\u00e9o d\u00e0i t\u1eeb 4 \u0111\u1ebfn 8 tu\u1ea7n).<\/p>\n GERD:<\/p>\n \u0110i\u1ec1u tr\u1ecb duy tr\u00ec: Ki\u1ec3m so\u00e1t v\u00e0 duy tr\u00ec tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh sau khi \u0111\u00e3 l\u00e0m l\u00e0nh c\u00e1c t\u1ed5n th\u01b0\u01a1ng c\u1ee7a vi\u00eam th\u1ef1c qu\u1ea3n b\u00e0o m\u00f2n. Th\u1eddi gian d\u00f9ng thu\u1ed1c duy tr\u00ec theo c\u00e1c nghi\u00ean c\u1ee9u c\u00f3 ki\u1ec3m so\u00e1t kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 12 th\u00e1ng.<\/p>\n D\u1ef1 ph\u00f2ng xu\u1ea5t huy\u1ebft: Gi\u1ea3m thi\u1ec3u nguy c\u01a1 x\u1ea3y ra bi\u1ebfn ch\u1ee9ng xu\u1ea5t huy\u1ebft \u0111\u01b0\u1eddng ti\u00eau h\u00f3a tr\u00ean \u1edf nh\u00f3m b\u1ec7nh nh\u00e2n trong t\u00ecnh tr\u1ea1ng nguy k\u1ecbch (h\u1ed3i s\u1ee9c t\u00edch c\u1ef1c).<\/p>\nZustafa 40mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n
Th\u00e0nh ph\u1ea7n<\/h3>\n
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Tr\u00ecnh b\u00e0y<\/h3>\n
T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Zustafa 40mg<\/h2>\n
C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n
Thu\u1ed1c Zustafa 40mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n
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Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n
Li\u1ec1u d\u00f9ng<\/h3>\n