{"id":139873,"date":"2025-09-19T09:02:39","date_gmt":"2025-09-19T02:02:39","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&#038;p=139873"},"modified":"2025-09-19T15:26:53","modified_gmt":"2025-09-19T08:26:53","slug":"augbactam-1g","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/augbactam-1g\/","title":{"rendered":"Augbactam 1g"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y, <\/strong><a href=\"https:\/\/hmm88i.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c <a href=\"https:\/\/hmm88i.com\/drug\/augbactam-1g\/\">Augbactam 1g<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty C\u1ed5 ph\u1ea7n H\u00f3a &#8211; D\u01b0\u1ee3c ph\u1ea9m Mekophar, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 893110691724.<\/strong><\/p>\n<h2>Augbactam 1g l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Thu\u1ed1c Augbactam 1g<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n<ul>\n<li>Amoxicillin: 875 mg<\/li>\n<li>Acid Clavulanic: 125 mg<\/li>\n<li>Ph\u1ee5 li\u1ec7u v\u0111<\/li>\n<\/ul>\n<p>D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: 893110691724<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 2 v\u1ec9 x 7 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n<figure id=\"attachment_139948\" aria-describedby=\"caption-attachment-139948\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-139948\" src=\"https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/09\/augbactam-1g.jpg\" alt=\"Augbactam 1g\" width=\"1200\" height=\"900\" title=\"\" srcset=\"https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/09\/augbactam-1g.jpg 1200w, https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/09\/augbactam-1g-533x400.jpg 533w, https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/09\/augbactam-1g-1067x800.jpg 1067w, https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/09\/augbactam-1g-768x576.jpg 768w, https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/09\/augbactam-1g-350x263.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-139948\" class=\"wp-caption-text\">Augbactam 1g \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, ti\u1ebft ni\u1ec7u, da v\u00e0 m\u00f4 m\u1ec1m<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Augbactam 1g<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Amoxicillin l\u00e0 kh\u00e1ng sinh nh\u00f3m beta-lactam, t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n.<\/p>\n<p>Acid Clavulanic kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n tr\u1ef1c ti\u1ebfp nh\u01b0ng gi\u00fap \u1ee9c ch\u1ebf men beta-lactamase, b\u1ea3o v\u1ec7 Amoxicillin kh\u1ecfi b\u1ecb ph\u00e1 h\u1ee7y.<br \/>\nT\u00e1c \u0111\u1ed9ng l\u00ean nhi\u1ec1u lo\u1ea1i vi khu\u1ea9n gram d\u01b0\u01a1ng: Streptococcus, Staphylococcus, Bacillus anthracis, Listeria, Clostridium,&#8230; Gram \u00e2m: H. influenzae, E. coli, Klebsiella, Neisseria, Salmonella, Shigella, Bacteroides&#8230;<\/p>\n<p>S\u1ef1 ph\u1ed1i h\u1ee3p c\u1ee7a hai ho\u1ea1t ch\u1ea5t gi\u00fap t\u0103ng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb, nh\u1ea5t l\u00e0 v\u1edbi nh\u1eefng vi khu\u1ea9n s\u1ea3n sinh beta-lactamase \u2013 lo\u1ea1i enzyme l\u00e0m m\u1ea5t t\u00e1c d\u1ee5ng c\u1ee7a kh\u00e1ng sinh th\u00f4ng th\u01b0\u1eddng.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<p>H\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u1ea1t \u0111\u1ec9nh trong huy\u1ebft thanh sau 1\u20132 gi\u1edd. Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a Amoxicillin kho\u1ea3ng 90%, Acid clavulanic kho\u1ea3ng 75%. Th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u (55-70% Amoxicillin, 30-40% Acid clavulanic). Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Amoxicillin 1-2 gi\u1edd v\u00e0 Acid clavulanic kho\u1ea3ng 1 gi\u1edd.<\/p>\n<h2>Thu\u1ed1c Augbactam 1g tr\u1ecb b\u1ec7nh g\u00ec?<\/h2>\n<p>Augbactamm 1g l\u00e0 thu\u1ed1c kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb ng\u1eafn h\u1ea1n c\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m khu\u1ea9n n\u1eb7ng, bao g\u1ed3m:<\/p>\n<ul>\n<li>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p: Vi\u00eam amidan, vi\u00eam xoang, vi\u00eam tai gi\u1eefa (khi c\u00e1c thu\u1ed1c kh\u00e1c kh\u00f4ng hi\u1ec7u qu\u1ea3).\u00a0Vi\u00eam ph\u1ebf qu\u1ea3n c\u1ea5p\/m\u1ea1n, vi\u00eam ph\u1ed5i-ph\u1ebf qu\u1ea3n do H. influenzae, Branhamella catarrhalis.<\/li>\n<li>Nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u &#8211; sinh d\u1ee5c: Vi\u00eam b\u00e0ng quang, ni\u1ec7u \u0111\u1ea1o, b\u1ec3 th\u1eadn do vi khu\u1ea9n s\u1ea3n beta-lactamase nh\u01b0 E. coli, Klebsiella.<\/li>\n<li>Nhi\u1ec5m khu\u1ea9n da &#8211; m\u00f4 m\u1ec1m: M\u1ee5n nh\u1ecdt, \u00e1p xe, nhi\u1ec5m tr\u00f9ng v\u1ebft th\u01b0\u01a1ng.<\/li>\n<li>Nhi\u1ec5m khu\u1ea9n x\u01b0\u01a1ng &#8211; kh\u1edbp: Vi\u00eam t\u1ee7y x\u01b0\u01a1ng.<\/li>\n<li>Nhi\u1ec5m khu\u1ea9n nha khoa: \u00c1p xe \u1ed5 r\u0103ng.<\/li>\n<li>Nhi\u1ec5m khu\u1ea9n kh\u00e1c: Nhi\u1ec5m khu\u1ea9n ph\u1ee5 khoa, \u1ed5 b\u1ee5ng.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng-C\u00e1ch d\u00f9ng Augbactam 1g<\/h2>\n<h3>Li\u1ec1u d\u00f9ng Augbactam 1g<\/h3>\n<p>T\u00f9y theo tr\u01b0\u1eddng h\u1ee3p m\u00e0 \u0111\u01b0\u1ee3c b\u00e1c s\u0129 ch\u1ec9 \u0111\u1ecbnh li\u1ec1u d\u00f9ng kh\u00e1c nhau, d\u01b0\u1edbi \u0111\u00e2y l\u00e0 li\u1ec1u d\u00f9ng tham kh\u1ea3o.<\/p>\n<p>Li\u1ec1u d\u00f9ng th\u00f4ng th\u01b0\u1eddng (ng\u01b0\u1eddi l\u1edbn v\u00e0 &gt;12 tu\u1ed5i): Nhi\u1ec5m khu\u1ea9n n\u1eb7ng: 1 vi\u00ean x 2 l\u1ea7n\/ng\u00e0y (m\u1ed7i 12 gi\u1edd).<\/p>\n<p>Kh\u00f4ng d\u00f9ng vi\u00ean 1g cho tr\u1ebb &lt;12 tu\u1ed5i.<\/p>\n<p>Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb kh\u00f4ng qu\u00e1 14 ng\u00e0y n\u1ebfu kh\u00f4ng c\u00f3 ch\u1ec9 \u0111\u1ecbnh ki\u1ec3m tra l\u1ea1i.<\/p>\n<h3>C\u00e1ch d\u00f9ng<\/h3>\n<p>Thu\u1ed1c Augbactam 1g d\u00f9ng \u0111\u1ec3 u\u1ed1ng, u\u1ed1ng v\u1edbi nhi\u1ec1u n\u01b0\u1edbc.<\/p>\n<p><strong>C\u00e1ch d\u00f9ng Augbactam 1g?<\/strong> N\u00ean u\u1ed1ng \u0111\u1ea7u b\u1eefa \u0103n \u0111\u1ec3 gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Augbactam 1g trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng Augbactam 1g cho ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o trong thu\u1ed1c.<\/p>\n<p>D\u1ecb \u1ee9ng v\u1edbi Penicillin, Cephalosporin.<\/p>\n<p>Ti\u1ec1n s\u1eed v\u00e0ng da, r\u1ed1i lo\u1ea1n gan m\u1eadt do Amoxicillin\/Clavulanat ho\u1eb7c Penicillin.<\/p>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<p>B\u1ec7nh nh\u00e2n gan, th\u1eadn: C\u1ea7n theo d\u00f5i ch\u1ee9c n\u0103ng v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u n\u1ebfu c\u1ea7n.<\/p>\n<p>\u0110\u1ecdc k\u1ef9 h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng tr\u01b0\u1edbc khi d\u00f9ng.<\/p>\n<p>Kh\u00f4ng d\u00f9ng thu\u1ed1c khi xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u h\u01b0 h\u1ecfng nh\u01b0 \u1ea9m m\u1ed1c, ch\u1ea3y n\u01b0\u1edbc, h\u1ebft h\u1ea1n d\u00f9ng.<\/p>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5 Augbactam 1g<\/h3>\n<p>Th\u01b0\u1eddng g\u1eb7p: Ti\u00eau ch\u1ea3y, ng\u1ee9a.<\/p>\n<p>\u00cdt g\u1eb7p: T\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, bu\u1ed3n n\u00f4n, vi\u00eam gan, v\u00e0ng da \u1ee9 m\u1eadt, t\u0103ng transaminase.<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Ph\u1ea3n v\u1ec7, ph\u00f9 Quincke, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u, vi\u00eam \u0111\u1ea1i tr\u00e0ng gi\u1ea3 m\u1ea1c, ban \u0111\u1ecf \u0111a d\u1ea1ng, h\u1ed9i ch\u1ee9ng Stevens-Johnson, vi\u00eam th\u1eadn k\u1ebd,&#8230;<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>Ph\u1ee5 n\u1eef mang thai: Tr\u00e1nh s\u1eed d\u1ee5ng trong 3 th\u00e1ng \u0111\u1ea7u, tr\u1eeb khi c\u1ea7n thi\u1ebft v\u00e0 c\u00f3 ch\u1ec9 \u0111\u1ecbnh b\u00e1c s\u0129.<\/p>\n<p>Ph\u1ee5 n\u1eef cho con b\u00fa: C\u00f3 th\u1ec3 d\u00f9ng, nh\u01b0ng theo d\u00f5i nguy c\u01a1 m\u1eabn c\u1ea3m nh\u1eb9 \u1edf tr\u1ebb do thu\u1ed1c b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 v\u1edbi l\u01b0\u1ee3ng nh\u1ecf.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t do \u0111\u00f3 c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>\u00cdt g\u00e2y tai bi\u1ebfn, th\u01b0\u1eddng dung n\u1ea1p t\u1ed1t. C\u00f3 th\u1ec3 g\u00e2y t\u0103ng kali huy\u1ebft do mu\u1ed1i kali c\u1ee7a Acid clavulanic. X\u1eed tr\u00ed b\u1eb1ng th\u1ea9m ph\u00e2n m\u00e1u n\u1ebfu c\u1ea7n thi\u1ebft.<\/p>\n<h3>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/h3>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\">Thu\u1ed1c k\u1ebft h\u1ee3p<\/td>\n<td style=\"width: 50%;\">T\u01b0\u01a1ng t\u00e1c<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50%;\">Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u<\/td>\n<td style=\"width: 50%;\">C\u1ea7n theo d\u00f5i th\u1eddi gian \u0111\u00f4ng m\u00e1u do thu\u1ed1c c\u00f3 th\u1ec3 k\u00e9o d\u00e0i th\u1eddi gian prothrombin.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50%;\">Thu\u1ed1c tr\u00e1nh thai u\u1ed1ng<\/td>\n<td style=\"width: 50%;\">C\u00f3 th\u1ec3 gi\u1ea3m hi\u1ec7u qu\u1ea3, n\u00ean b\u00e1o tr\u01b0\u1edbc cho b\u1ec7nh nh\u00e2n.<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50%;\">Probenecid<\/td>\n<td style=\"width: 50%;\">L\u00e0m k\u00e9o d\u00e0i th\u1eddi gian \u0111\u00e0o th\u1ea3i Amoxicillin.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>B\u1ea3o qu\u1ea3n<\/h3>\n<p>N\u01a1i kh\u00f4 m\u00e1t, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<p>Tr\u00e1nh xa t\u1ea7m tay tr\u1ebb em.<\/p>\n<h2>S\u1ea3n ph\u1ea9m t\u01b0\u01a1ng t\u1ef1<\/h2>\n<p>Qu\u00fd kh\u00e1ch c\u00f3 th\u1ec3 tham kh\u1ea3o c\u00e1c s\u1ea3n ph\u1ea9m kh\u00e1c c\u1ee7a nh\u00e0 thu\u1ed1c c\u00f3 c\u00f9ng ho\u1ea1t ch\u1ea5t v\u00e0 t\u00e1c d\u1ee5ng v\u1edbi Augbactam 1g nh\u01b0:<\/p>\n<p><a href=\"https:\/\/hmm88i.com\/drug\/thuoc-klamentin-875-125-duoc-si-luu-van-hoang\/\" data-mil=\"46348\">Klamentin 875\/125<\/a> \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn nhi\u1ec5m khu\u1ea9n, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m D\u01b0\u1ee3c H\u1eadu Giang.<\/p>\n<p><a href=\"https:\/\/hmm88i.com\/drug\/augxicine-1g\/\" data-mil=\"46348\">Augxicine 1g<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty D\u01b0\u1ee3c Ph\u1ea9m Trung \u01af\u01a1ng Vidipha, \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u, nhi\u1ec5m khu\u1ea9n da v\u00e0 m\u00f4 m\u1ec1m.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p class=\"heading-title\">Amoxicillin\/clavulanic acid-associated severe neutropenia, truy c\u1eadp ng\u00e0y 19 th\u00e1ng 09 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33441473\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33441473\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Augbactamm 1g l\u00e0 thu\u1ed1c kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb ng\u1eafn h\u1ea1n c\u00e1c tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m khu\u1ea9n n\u1eb7ng, bao g\u1ed3m nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u<\/p>\n","protected":false},"author":1,"featured_media":139950,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-139873","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product\/139873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/comments?post=139873"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media\/139950"}],"wp:attachment":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media?parent=139873"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_cat?post=139873"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_tag?post=139873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}