{"id":124050,"date":"2025-06-20T16:41:16","date_gmt":"2025-06-20T09:41:16","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&#038;p=124050"},"modified":"2025-07-24T11:48:09","modified_gmt":"2025-07-24T04:48:09","slug":"ofev-150mg","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/ofev-150mg\/","title":{"rendered":"Ofev 150mg"},"content":{"rendered":"<p><strong>Trong b\u00e0i vi\u1ebft n\u00e0y,<\/strong> <a href=\"https:\/\/hmm88i.com\/drug\/\"><strong>d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng<\/strong><\/a><strong> gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c<\/strong> <strong>Ofev 150mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Catalent Germany Eberbach GmbH (C\u01a1 s\u1edf \u0111\u00f3ng g\u00f3i &amp; xu\u1ea5t x\u01b0\u1edfng: Boehringer Ingelheim Pharma GmbH &amp; Co. KG), c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN3-183-19.<\/strong><\/p>\n<h2>Ofev 150mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n<h3>Th\u00e0nh ph\u1ea7n<\/h3>\n<p><strong>Ofev 150mg<\/strong> l\u00e0 vi\u00ean nang m\u1ec1m ch\u1ee9a <strong>Nintedanib<\/strong> 150mg.<\/p>\n<h3>Tr\u00ecnh b\u00e0y<\/h3>\n<p>S\u0110K: VN3-183-19<\/p>\n<p>Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 6 v\u1ec9 x 10 vi\u00ean<\/p>\n<p>Xu\u1ea5t x\u1ee9: Germany<\/p>\n<figure id=\"attachment_124051\" aria-describedby=\"caption-attachment-124051\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-124051\" src=\"https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/06\/Ofev-150mg.jpg\" alt=\"Ofev 150mg \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf\" width=\"1200\" height=\"800\" title=\"\" srcset=\"https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/06\/Ofev-150mg.jpg 1200w, https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/06\/Ofev-150mg-600x400.jpg 600w, https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/06\/Ofev-150mg-768x512.jpg 768w, https:\/\/hmm88i.com\/drug\/wp-content\/uploads\/2025\/06\/Ofev-150mg-350x233.jpg 350w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-124051\" class=\"wp-caption-text\">Ofev 150mg \u0111i\u1ec1u tr\u1ecb ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf<\/figcaption><\/figure>\n<h2>T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Ofev 150mg<\/h2>\n<h3>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n<p>Nintedanib l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf Tyrosine kinase (TKI) \u0111a \u0111\u00edch, ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch g\u1eafn v\u00e0o v\u1ecb tr\u00ed ATP v\u00e0 \u1ee9c ch\u1ebf c\u00e1c th\u1ee5 th\u1ec3 y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng nh\u01b0 VEGFR 1-3, PDGFR \u03b1\/\u03b2, v\u00e0 FGFR 1-3. C\u01a1 ch\u1ebf n\u00e0y gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u m\u1edbi v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c nguy\u00ean b\u00e0o s\u1ee3i, t\u1eeb \u0111\u00f3 c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng ung th\u01b0 (l\u00e0m gi\u1ea3m s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 cung c\u1ea5p m\u00e1u cho kh\u1ed1i u) v\u00e0 ch\u1ed1ng x\u01a1 h\u00f3a (\u1ee9c ch\u1ebf t\u0103ng sinh v\u00e0 di chuy\u1ec3n c\u1ee7a nguy\u00ean b\u00e0o s\u1ee3i trong c\u00e1c b\u1ec7nh nh\u01b0 x\u01a1 ph\u1ed5i). Ngo\u00e0i ra, Nintedanib c\u0169ng \u1ee9c ch\u1ebf m\u1ed9t s\u1ed1 kinase kh\u00e1c nh\u01b0 Flt-3, Lck v\u00e0 Src.<\/p>\n<h3>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n<ul>\n<li>H\u1ea5p thu: \u0110\u1ea1t \u0111\u1ec9nh 2-4 gi\u1edd sau u\u1ed1ng (\u0103n no). Sinh kh\u1ea3 d\u1ee5ng th\u1ea5p (4,69%), t\u0103ng 20% khi d\u00f9ng c\u00f9ng th\u1ee9c \u0103n.<\/li>\n<li>Ph\u00e2n b\u1ed1: Ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i v\u00e0o m\u00f4 (Vss: 1050 L), g\u1eafn k\u1ebft protein cao (97,8%) ch\u1ee7 y\u1ebfu v\u1edbi albumin.<\/li>\n<li>Chuy\u1ec3n h\u00f3a: Ch\u1ee7 y\u1ebfu th\u1ee7y ph\u00e2n b\u1edfi esterase, sau \u0111\u00f3 glucuronide h\u00f3a b\u1edfi UGT. Ch\u1ec9 m\u1ed9t ph\u1ea7n nh\u1ecf (5%) chuy\u1ec3n h\u00f3a qua CYP3A4.<\/li>\n<li>Th\u1ea3i tr\u1eeb: \u0110\u1ed9 thanh th\u1ea3i huy\u1ebft t\u01b0\u01a1ng cao. Ch\u1ee7 y\u1ebfu th\u1ea3i tr\u1eeb qua ph\u00e2n\/m\u1eadt (93,4%). Th\u1ea3i qua th\u1eadn r\u1ea5t \u00edt (0,05%). Th\u1eddi gian b\u00e1n th\u1ea3i 10-15 gi\u1edd.<\/li>\n<\/ul>\n<h2>Thu\u1ed1c Ofev 150mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n<ul>\n<li>Ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf (NSCLC) t\u1ea1i ch\u1ed7 ti\u1ebfn tri\u1ec3n, di c\u0103n ho\u1eb7c t\u00e1i ph\u00e1t: D\u00f9ng k\u1ebft h\u1ee3p v\u1edbi docetaxel cho ung th\u01b0 bi\u1ec3u m\u00f4 tuy\u1ebfn sau khi \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb h\u00f3a tr\u1ecb b\u01b0\u1edbc m\u1ed9t.<\/li>\n<li>X\u01a1 h\u00f3a ph\u1ed5i t\u1ef1 ph\u00e1t (IPF): Gi\u00fap l\u00e0m ch\u1eadm ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh.<\/li>\n<\/ul>\n<h2>Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c Ofev 150mg<\/h2>\n<ul>\n<li>\u0110\u1ed1i v\u1edbi NSCLC: 200mg\/l\u1ea7n, 2 l\u1ea7n\/ng\u00e0y (c\u00e1ch nhau kho\u1ea3ng 12 gi\u1edd), t\u1eeb ng\u00e0y 2 \u0111\u1ebfn ng\u00e0y 21 c\u1ee7a chu k\u1ef3 \u0111i\u1ec1u tr\u1ecb docetaxel 21 ng\u00e0y. Kh\u00f4ng d\u00f9ng v\u00e0o ng\u00e0y 1 v\u00e0 kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 400mg\/ng\u00e0y. B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c Ofev sau khi ng\u1eebng docetaxel n\u1ebfu v\u1eabn c\u00f2n l\u1ee3i \u00edch l\u00e2m s\u00e0ng ho\u1eb7c kh\u00f4ng xu\u1ea5t hi\u1ec7n \u0111\u1ed9c t\u00ednh kh\u00f4ng th\u1ec3 ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c.<\/li>\n<li>\u0110\u1ed1i v\u1edbi IPF: 150mg\/l\u1ea7n, 2 l\u1ea7n\/ng\u00e0y (c\u00e1ch nhau kho\u1ea3ng 12 gi\u1edd). Kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 li\u1ec1u t\u1ed1i \u0111a 300mg\/ng\u00e0y.<\/li>\n<\/ul>\n<h2>C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c Ofev 150mg<\/h2>\n<p>Ofev 150mg d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, c\u00f9ng v\u1edbi th\u1ee9c \u0103n. N\u00ean nu\u1ed1t nguy\u00ean vi\u00ean thu\u1ed1c v\u1edbi n\u01b0\u1edbc, kh\u00f4ng nhai ho\u1eb7c nghi\u1ec1n n\u00e1t.<\/p>\n<h2>Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Ofev 150mg trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n<ul>\n<li>Qu\u00e1 m\u1eabn v\u1edbi Nintedanib, l\u1ea1c, \u0111\u1eadu n\u00e0nh ho\u1eb7c b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n<li>Ph\u1ee5 n\u1eef nghi ng\u1edd c\u00f3 thai, \u0111ang mang thai ho\u1eb7c \u0111ang cho con b\u00fa.<\/li>\n<li>\u0110\u1ed1i v\u1edbi \u0111i\u1ec1u tr\u1ecb NSCLC, c\u1ea7n xem x\u00e9t th\u00eam c\u00e1c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh c\u1ee7a docetaxel.<\/li>\n<\/ul>\n<h2>L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c Ofev 150mg<\/h2>\n<h3>Th\u1eadn tr\u1ecdng<\/h3>\n<ul>\n<li>Xu\u1ea5t huy\u1ebft: Thu\u1ed1c c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft. C\u1ea7n th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed xu\u1ea5t huy\u1ebft, \u0111ang d\u00f9ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng.<\/li>\n<li>Thuy\u00ean t\u1eafc huy\u1ebft kh\u1ed1i \u0111\u1ed9ng m\u1ea1ch\/t\u0129nh m\u1ea1ch: Th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 tim m\u1ea1ch.<\/li>\n<li>Th\u1ee7ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a: Th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed ph\u1eabu thu\u1eadt \u1ed5 b\u1ee5ng, lo\u00e9t, vi\u00eam t\u00fai th\u1eeba ho\u1eb7c \u0111ang d\u00f9ng corticosteroid\/NSAIDs. Ch\u1ec9 b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c sau \u00edt nh\u1ea5t 4 tu\u1ea7n k\u1ec3 t\u1eeb ph\u1eabu thu\u1eadt l\u1edbn.<\/li>\n<li>Ch\u1eadm l\u00e0nh v\u1ebft th\u01b0\u01a1ng: Nintedanib c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn qu\u00e1 tr\u00ecnh l\u00e0nh v\u1ebft th\u01b0\u01a1ng.<\/li>\n<\/ul>\n<h3>T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n<ul>\n<li>R\u1ea5t ph\u1ed5 bi\u1ebfn: Ti\u00eau ch\u1ea3y, t\u0103ng men gan (ALT, AST, ALKP), bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au b\u1ee5ng, gi\u1ea3m ngon mi\u1ec7ng, vi\u00eam ni\u00eam m\u1ea1c, n\u1ed5i m\u1ea9n da, xu\u1ea5t huy\u1ebft (nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh).<\/li>\n<li>Ph\u1ed5 bi\u1ebfn: Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh (k\u00e8m ho\u1eb7c kh\u00f4ng k\u00e8m s\u1ed1t), gi\u1ea3m ti\u1ec3u c\u1ea7u, m\u1ea5t c\u00e2n b\u1eb1ng \u0111i\u1ec7n gi\u1ea3i, m\u1ea5t n\u01b0\u1edbc, gi\u1ea3m c\u00e2n, r\u1ed1i lo\u1ea1n th\u1ea7n kinh ngo\u1ea1i vi, thuy\u00ean t\u1eafc huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch, t\u0103ng huy\u1ebft \u00e1p, th\u1ee7ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, vi\u00eam t\u1ee5y, t\u0103ng bilirubin m\u00e1u, t\u0103ng gamma-glutamyltransferase, t\u1ed5n th\u01b0\u01a1ng gan do thu\u1ed1c.<\/li>\n<\/ul>\n<h3>T\u01b0\u01a1ng t\u00e1c<\/h3>\n<ul>\n<li>Ch\u1ea5t \u1ee9c ch\u1ebf P-glycoprotein (P-gp) m\u1ea1nh (v\u00ed d\u1ee5: ketoconazol, erythromycin): C\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Nintedanib. C\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd kh\u1ea3 n\u0103ng dung n\u1ea1p.<\/li>\n<li>Ch\u1ea5t c\u1ea3m \u1ee9ng P-gp m\u1ea1nh (v\u00ed d\u1ee5: rifampicin, carbamazepin, phenytoin, St. John\u2019s wort): C\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 Nintedanib.<\/li>\n<li>Th\u1ee9c \u0103n: D\u00f9ng Ofev c\u00f9ng th\u1ee9c \u0103n gi\u00fap c\u1ea3i thi\u1ec7n h\u1ea5p thu.<\/li>\n<li>C\u00e1c enzyme Cytochrome (CYP): Kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c qua CYP l\u00e0 th\u1ea5p.<\/li>\n<\/ul>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 b\u00e0 m\u1eb9 cho con b\u00fa<\/h3>\n<p>N\u00ean s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai ph\u00f9 h\u1ee3p trong v\u00e0 \u00edt nh\u1ea5t 3 th\u00e1ng sau khi ng\u1eebng thu\u1ed1c.<\/p>\n<h3>L\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/h3>\n<p>B\u1ec7nh nh\u00e2n n\u00ean th\u1eadn tr\u1ecdng.<\/p>\n<h3>Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed<\/h3>\n<p>Ch\u01b0a c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u cho Nintedanib. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, c\u1ea7n t\u1ea1m ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u00e0 th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 chung ph\u00f9 h\u1ee3p (v\u00ed d\u1ee5: b\u00f9 n\u01b0\u1edbc, \u0111i\u1ec7n gi\u1ea3i).<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p>Sven Wind, Ulrike Schmid, Matthias Freiwald, Kristell Marzin, Ralf Lotz, Thomas Ebner, Peter Stopfer, Claudia Dallinger. Clinical Pharmacokinetics and Pharmacodynamics of Nintedanib, truy c\u1eadp ng\u00e0y 20 th\u00e1ng 06 n\u0103m 2025 t\u1eeb <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31016670\/\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31016670\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Ofev 150mg \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Catalent Germany Eberbach GmbH (C\u01a1 s\u1edf \u0111\u00f3ng g\u00f3i &amp; xu\u1ea5t x\u01b0\u1edfng: Boehringer Ingelheim Pharma GmbH &amp; Co. KG), c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VN3-183-19.<\/p>\n","protected":false},"author":1,"featured_media":124052,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[89],"product_tag":[],"class_list":{"0":"post-124050","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-thuoc","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product\/124050","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/types\/product"}],"author":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/comments?post=124050"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media\/124052"}],"wp:attachment":[{"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/media?parent=124050"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_cat?post=124050"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/hmm88i.com\/drug\/wp-json\/wp\/v2\/product_tag?post=124050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}