Oteracil Kali (Oxo): 19,6mg<\/li>\n<\/ul>\nT\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean.<\/p>\n
Tr\u00ecnh b\u00e0y<\/h3>\n
S\u0110K: 499110520624 (VN-22392-19)<\/p>\n
Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 4 v\u1ec9 x 14 vi\u00ean<\/p>\n
Xu\u1ea5t x\u1ee9: Nh\u1eadt B\u1ea3n<\/p>\n
TS-One Capsule 20 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 d\u1ea1 d\u00e0y ti\u1ebfn tri\u1ec3n \u1edf ng\u01b0\u1eddi l\u1edbn<\/figcaption><\/figure>\nT\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c TS-One Capsule 20<\/h2>\nC\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n\n- Tegafur: Ch\u1ea5t ch\u1ed1ng ung th\u01b0 ho\u1ea1t \u0111\u1ed9ng d\u01b0\u1edbi d\u1ea1ng ti\u1ec1n ch\u1ea5t c\u1ee7a 5-Fluorouracil (5-FU). Sau khi h\u1ea5p th\u1ee5 v\u00e0o c\u01a1 th\u1ec3, Tegafur chuy\u1ec3n h\u00f3a th\u00e0nh 5-FU, \u1ee9c ch\u1ebf s\u1ef1 t\u1ed5ng h\u1ee3p DNA v\u00e0 RNA c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0, ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ph\u00e2n chia t\u1ebf b\u00e0o ung th\u01b0.<\/li>\n
- Gimeracil: Ch\u1ea5t \u1ee9c ch\u1ebf enzyme dihydroxypyrimidine dehydrogenase (DPD). DPD l\u00e0 enzyme ch\u00ednh ch\u1ecbu tr\u00e1ch nhi\u1ec7m chuy\u1ec3n h\u00f3a 5-FU ra kh\u1ecfi c\u01a1 th\u1ec3. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf DPD, Gimeracil gi\u00fap duy tr\u00ec n\u1ed3ng \u0111\u1ed9 5-FU trong m\u00e1u \u1edf m\u1ee9c cao v\u00e0 \u1ed5n \u0111\u1ecbnh, k\u00e9o d\u00e0i th\u1eddi gian t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c.<\/li>\n
- Oteracil Kali: Ch\u1ea5t \u1ee9c ch\u1ebf enzyme OPRT (Orotate Phosphoribosyltransferase), ch\u1ee7 y\u1ebfu t\u1ed3n t\u1ea1i trong t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 m\u00f4 ru\u1ed9t. Oteracil gi\u00fap b\u1ea3o v\u1ec7 c\u00e1c m\u00f4 l\u00e0nh \u1edf \u0111\u01b0\u1eddng ti\u00eau h\u00f3a kh\u1ecfi t\u00e1c d\u1ee5ng \u0111\u1ed9c c\u1ee7a 5-FU, gi\u1ea3m thi\u1ec3u c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y v\u00e0 ru\u1ed9t.<\/li>\n<\/ul>\n
\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\nH\u1ea5p Thu<\/h4>\n
Sau khi u\u1ed1ng, TS-One \u0111\u01b0\u1ee3c h\u1ea5p thu hi\u1ec7u qu\u1ea3 qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. \u0110\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c s\u1ef1 h\u1ea5p thu t\u1ed1i \u01b0u, n\u00ean u\u1ed1ng thu\u1ed1c sau b\u1eefa \u0103n.<\/p>\n
Ph\u00e2n B\u1ed1<\/h4>\n
C\u00e1c th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a TS-One li\u00ean k\u1ebft v\u1edbi protein trong m\u00e1u \u1edf c\u00e1c m\u1ee9c \u0111\u1ed9 kh\u00e1c nhau.<\/p>\n
Chuy\u1ec3n H\u00f3a<\/h4>\n
Tegafur l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t \u0111\u01b0\u1ee3c gan chuy\u1ec3n h\u00f3a th\u00e0nh 5-Fluorouracil (5-FU), m\u1ed9t ho\u1ea1t ch\u1ea5t ch\u1ed1ng ung th\u01b0 m\u1ea1nh m\u1ebd, nh\u1edd v\u00e0o enzyme CYP2A6. Gimeracil \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c k\u00e9o d\u00e0i th\u1eddi gian t\u1ed3n t\u1ea1i c\u1ee7a 5-FU trong m\u00e1u b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf enzyme DPD (dihydro-pyrimidine dehydrogenase), gi\u00fap duy tr\u00ec n\u1ed3ng \u0111\u1ed9 5-FU \u1edf m\u1ee9c \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3. Trong khi \u0111\u00f3, Oteracil b\u1ea3o v\u1ec7 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf enzyme OPRT (orotate phosphoribosyltransferase) t\u1ea1i \u0111\u00e2y, gi\u00fap gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a 5-FU l\u00ean c\u00e1c t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh trong ni\u00eam m\u1ea1c ru\u1ed9t.<\/p>\n
Th\u1ea3i Tr\u1eeb<\/h4>\n
C\u00e1c th\u00e0nh ph\u1ea7n c\u1ee7a TS-One v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a ch\u00fang ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u. \u0110\u00e1ng ch\u00fa \u00fd, th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a 5-FU sau khi d\u00f9ng TS-One k\u00e9o d\u00e0i h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi vi\u1ec7c d\u00f9ng 5-FU \u0111\u01a1n l\u1ebb. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y vai tr\u00f2 quan tr\u1ecdng c\u1ee7a Gimeracil trong vi\u1ec7c duy tr\u00ec n\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u1ed5n \u0111\u1ecbnh trong c\u01a1 th\u1ec3.<\/p>\n
Thu\u1ed1c TS-One Capsule 20 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n
TS-One Capsule 20 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 d\u1ea1 d\u00e0y ti\u1ebfn tri\u1ec3n \u1edf ng\u01b0\u1eddi l\u1edbn. Thu\u1ed1c ph\u00e1t huy hi\u1ec7u qu\u1ea3 t\u1ed1t nh\u1ea5t khi \u0111\u01b0\u1ee3c d\u00f9ng ph\u1ed1i h\u1ee3p v\u1edbi Cisplatin.<\/p>\n
Li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c TS-One Capsule 20<\/h2>\n\n- Vi\u1ec7c s\u1eed d\u1ee5ng TS-One Capsule 20 ph\u1ea3i tu\u00e2n th\u1ee7 nghi\u00eam ng\u1eb7t ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129, \u0111\u1eb7c bi\u1ec7t l\u00e0 li\u1ec1u d\u00f9ng, v\u00ec n\u00f3 ph\u1ee5 thu\u1ed9c v\u00e0o Di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 (BSA) c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n.<\/li>\n
- Li\u1ec1u chu\u1ea9n \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o d\u1ef1a tr\u00ean BSA, d\u00f9ng 2 l\u1ea7n\/ng\u00e0y:<\/li>\n<\/ul>\n
\n\n\n| Di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 (m2)<\/td>\n | M\u1ed7i li\u1ec1u (t\u00ednh theo Tegafur)<\/td>\n | S\u1ed1 vi\u00ean\/li\u1ec1u (Vi\u00ean nang 20 mg)<\/td>\n | S\u1ed1 vi\u00ean\/li\u1ec1u (Vi\u00ean nang 25 mg)<\/td>\n<\/tr>\n |
\n| < 1.25<\/td>\n | 40 mg<\/td>\n | 2<\/td>\n | 0<\/td>\n<\/tr>\n |
\n| 1.25 \u0111\u1ebfn < 1.5<\/td>\n | 50 mg<\/td>\n | 0<\/td>\n | 2<\/td>\n<\/tr>\n |
\n| \u2265 1.5<\/td>\n | 60 mg<\/td>\n | 3<\/td>\n | 0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n- Li\u1ec7u tr\u00ecnh \u0111i\u1ec1u tr\u1ecb:\n
\n- M\u1ed9t \u0111\u1ee3t \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i 21 ng\u00e0y li\u00ean ti\u1ebfp d\u00f9ng thu\u1ed1c, sau \u0111\u00f3 ngh\u1ec9 14 ng\u00e0y.<\/li>\n
- Li\u1ec7u tr\u00ecnh n\u00e0y \u0111\u01b0\u1ee3c l\u1eb7p l\u1ea1i m\u1ed7i 5 tu\u1ea7n\/\u0111\u1ee3t.<\/li>\n
- Li\u1ec1u d\u00f9ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh (t\u0103ng, gi\u1ea3m ho\u1eb7c ng\u1eebng thu\u1ed1c) t\u00f9y theo th\u1ec3 tr\u1ea1ng v\u00e0 b\u1ec7nh l\u00fd n\u1ec1n c\u1ee7a t\u1eebng ng\u01b0\u1eddi b\u1ec7nh.<\/li>\n<\/ul>\n<\/li>\n
- Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u cho ng\u01b0\u1eddi cao tu\u1ed5i, b\u1ec7nh nh\u00e2n suy th\u1eadn nh\u1eb9 ho\u1eb7c suy gan.<\/li>\n
- Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng TS-One Capsule 20 cho tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i.<\/li>\n<\/ul>\n
C\u00e1ch d\u00f9ng c\u1ee7a thu\u1ed1c TS-One Capsule 20<\/h2>\n\n- U\u1ed1ng nguy\u00ean vi\u00ean thu\u1ed1c v\u1edbi n\u01b0\u1edbc.<\/li>\n
- U\u1ed1ng sau b\u1eefa \u0103n, v\u00e0o bu\u1ed5i s\u00e1ng v\u00e0 t\u1ed1i, \u0111\u1ec3 tr\u00e1nh \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c.<\/li>\n<\/ul>\n
Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c TS-One Capsule 20 trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n\n- B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng n\u1eb7ng v\u1edbi Tegafur, Gimeracil, Oteracil kali ho\u1eb7c b\u1ea5t k\u1ef3 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u1ee7a thu\u1ed1c.<\/li>\n
- B\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn\/suy gan n\u1eb7ng.<\/li>\n
- B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng thu\u1ed1c ch\u1ed1ng ung th\u01b0 nh\u00f3m fluoropyrimidin kh\u00e1c (v\u00ed d\u1ee5: capecitabin, 5-FU, tegafur) ho\u1eb7c \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng flucytosin. C\u1ea7n c\u00f3 th\u1eddi gian ngh\u1ec9 t\u1ed1i thi\u1ec3u 7 ng\u00e0y gi\u1eefa c\u00e1c li\u1ec7u ph\u00e1p n\u00e0y.<\/li>\n
- B\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng sorivudin ho\u1eb7c brivudin ho\u1eb7c trong v\u00f2ng 4 tu\u1ea7n sau li\u1ec1u cu\u1ed1i c\u00f9ng.<\/li>\n
- Ph\u1ee5 n\u1eef nghi ng\u1edd c\u00f3 thai ho\u1eb7c \u0111ang mang thai.<\/li>\n
- Ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/li>\n
- B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh c\u00f3 thi\u1ebfu h\u1ee5t dihydropyrimidin dehydrogenase (DPD).<\/li>\n<\/ul>\n
L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c TS-One Capsule 20<\/h2>\nTh\u1eadn tr\u1ecdng<\/h3>\n |