{"id":119957,"date":"2025-05-23T10:34:11","date_gmt":"2025-05-23T03:34:11","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=119957"},"modified":"2025-07-24T13:13:31","modified_gmt":"2025-07-24T06:13:31","slug":"pprunitil","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/pprunitil\/","title":{"rendered":"Prunitil 40mg\/12.5mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n thu\u1ed1c Prunitil \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Kh\u00e1nh H\u00f2a c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 VD-35733-22<\/strong><\/p>\n

Prunitil l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n

Th\u00e0nh ph\u1ea7n<\/h3>\n

Trong m\u1ed7i vi\u00ean n\u00e9n Prunitil<\/strong> c\u00f3 ch\u1ee9a:<\/p>\n

    \n
  • Telmisartan \u2026\u2026\u2026\u2026\u2026\u2026\u2026.40mg<\/li>\n
  • Hydrochlorothiazide \u2026\u2026\u202612,5mg<\/li>\n
  • C\u00e1c t\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 vi\u00ean.<\/li>\n<\/ul>\n

    D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n<\/p>\n

    Tr\u00ecnh b\u00e0y<\/h3>\n

    S\u0110K: VD-35733-22<\/p>\n

    Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 20 v\u1ec9 x 10 vi\u00ean<\/p>\n

    Xu\u1ea5t x\u1ee9: Vi\u1ec7t Nam<\/p>\n

    H\u1ea1n s\u1eed d\u1ee5ng: 36 th\u00e1ng<\/p>\n

    T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Prunitil<\/h2>\n

    C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n
      \n
    • Telmisartan<\/li>\n<\/ul>\n

      L\u00e0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc th\u1ee5 th\u1ec3 Angiotensin II lo\u1ea1i AT1, Telmisartan ng\u0103n ch\u1eb7n t\u00e1c \u0111\u1ed9ng g\u00e2y co m\u1ea1ch v\u00e0 ti\u1ebft aldosteron c\u1ee7a Angiotensin II, t\u1eeb \u0111\u00f3 l\u00e0m gi\u00e3n m\u1ea1ch v\u00e0 gi\u1ea3m huy\u1ebft \u00e1p.
      \nKh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn bradykinin nh\u01b0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n, do \u0111\u00f3 tr\u00e1nh \u0111\u01b0\u1ee3c t\u00e1c d\u1ee5ng ph\u1ee5 ho dai d\u1eb3ng. Thu\u1ed1c \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t, th\u00edch h\u1ee3p cho b\u1ec7nh nh\u00e2n kh\u00f4ng d\u00f9ng \u0111\u01b0\u1ee3c ACEI. Hi\u1ec7u qu\u1ea3 h\u1ea1 \u00e1p k\u00e9o d\u00e0i \u0111\u1ebfn 24 gi\u1edd v\u00e0 kh\u00f4ng g\u00e2y ph\u1ea3n \u1ee9ng d\u1ed9i khi ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t.<\/p>\n

        \n
      • Hydroclorothiazid<\/li>\n<\/ul>\n

        Thu\u1ed9c nh\u00f3m thiazid, thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng l\u1ee3i ti\u1ec3u b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu Na\u207a v\u00e0 Cl\u207b \u1edf \u1ed1ng l\u01b0\u1ee3n xa, l\u00e0m t\u0103ng th\u1ea3i natri, clorid, kali v\u00e0 n\u01b0\u1edbc. K\u1ebft qu\u1ea3 l\u00e0 gi\u1ea3m th\u1ec3 t\u00edch huy\u1ebft t\u01b0\u01a1ng v\u00e0 gi\u1ea3m s\u1ee9c c\u1ea3n ngo\u1ea1i vi, d\u1eabn \u0111\u1ebfn h\u1ea1 huy\u1ebft \u00e1p.
        \nT\u00e1c d\u1ee5ng l\u1ee3i ti\u1ec3u kh\u1edfi ph\u00e1t trong 2 gi\u1edd, \u0111\u1ea1t \u0111\u1ec9nh sau 4 gi\u1edd v\u00e0 k\u00e9o d\u00e0i 6\u201312 gi\u1edd. Ngo\u00e0i ra, thu\u1ed1c c\u00f2n gi\u00fap t\u0103ng hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p kh\u00e1c khi s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p.<\/p>\n

        \u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n

        H\u1ea5p thu<\/h4>\n

        Telmisartan: H\u1ea5p thu nhanh, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong 0,5 \u2013 1 gi\u1edd. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 42%. Th\u1ee9c \u0103n \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n

        Hydroclorothiazid: H\u1ea5p thu t\u01b0\u01a1ng \u0111\u1ed1i nhanh, \u0111\u1ea1t \u0111\u1ec9nh sau 1\u20133 gi\u1edd, sinh kh\u1ea3 d\u1ee5ng kho\u1ea3ng 60%. C\u00f3 th\u1ec3 gi\u1ea3m \u1edf b\u1ec7nh nh\u00e2n suy tim.<\/p>\n

        Ph\u00e2n b\u1ed1<\/h4>\n

        Telmisartan: G\u1eafn m\u1ea1nh v\u00e0o protein huy\u1ebft t\u01b0\u01a1ng (>99%), ch\u1ee7 y\u1ebfu l\u00e0 albumin. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 l\u1edbn (~500 L).<\/p>\n

        Hydroclorothiazid: G\u1eafn k\u1ebft protein kho\u1ea3ng 68%, th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 t\u1eeb 0,83\u20131,14 L\/kg. Thu\u1ed1c qua nhau thai v\u00e0 t\u1eadp trung trong thai nhi.<\/p>\n

        Chuy\u1ec3n h\u00f3a<\/h4>\n

        Telmisartan: Chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu th\u00e0nh d\u1ea1ng kh\u00f4ng ho\u1ea1t t\u00ednh (Acylglucuronid). Kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi enzym CYP450.<\/p>\n

        Hydroclorothiazid: Kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a.<\/p>\n

        Th\u1ea3i tr\u1eeb<\/h4>\n

        Telmisartan: Th\u1ea3i ch\u1ee7 y\u1ebfu qua m\u1eadt v\u00e0o ph\u00e2n (97%), \u00edt qua n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i >20 gi\u1edd.<\/p>\n

        Hydroclorothiazid: Th\u1ea3i tr\u1eeb qua th\u1eadn ch\u1ee7 y\u1ebfu \u1edf d\u1ea1ng nguy\u00ean v\u1eb9n, ~60% li\u1ec1u trong 48 gi\u1edd. Th\u1eddi gian b\u00e1n th\u1ea3i t\u1eeb 10\u201315 gi\u1edd, k\u00e9o d\u00e0i \u1edf ng\u01b0\u1eddi suy th\u1eadn.<\/p>\n

        Thu\u1ed1c Prunitil \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n
          \n
        • \u0110\u01b0\u1ee3c s\u1eed d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p ch\u01b0a \u0111\u1ea1t ki\u1ec3m so\u00e1t \u0111\u1ea7y \u0111\u1ee7 v\u1edbi Telmisartan \u0111\u01a1n \u0111\u1ed9c.<\/li>\n
        • H\u1ed7 tr\u1ee3 ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p trong tr\u01b0\u1eddng h\u1ee3p t\u0103ng huy\u1ebft \u00e1p nguy\u00ean ph\u00e1t.<\/li>\n<\/ul>\n
          \"Prunitil\"
          Thu\u1ed1c Prunitil 40mg\/12.5mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p v\u00f4 c\u0103n \u1edfn g\u01b0\u1eddi tr\u01b0\u1eddng th\u00e0nh khi s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u01a1n tr\u1ecb li\u1ec7u nh\u01b0ng kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c huy\u1ebft \u00e1p<\/figcaption><\/figure>\n

          Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch s\u1eed d\u1ee5ng<\/h2>\n

          Li\u1ec1u d\u00f9ng<\/h3>\n
            \n
          • Li\u1ec1u khuy\u1ebfn c\u00e1o th\u00f4ng th\u01b0\u1eddng l\u00e0 1 vi\u00ean Prunitil m\u1ed7i ng\u00e0y.<\/li>\n
          • B\u1ec7nh nh\u00e2n suy th\u1eadn: Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng thu\u1ed1c \u1edf ng\u01b0\u1eddi suy th\u1eadn n\u1eb7ng (\u0111\u1ed9 thanh th\u1ea3i creatinin < 30 mL\/ph\u00fat) do th\u00e0nh ph\u1ea7n Hydroclorothiazid. C\u1ea7n th\u1eadn tr\u1ecdng v\u00e0 theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn \u0111\u1ecbnh k\u1ef3 n\u1ebfu d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh.<\/li>\n
          • B\u1ec7nh nh\u00e2n suy gan: Kh\u00f4ng s\u1eed d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng. V\u1edbi tr\u01b0\u1eddng h\u1ee3p suy gan nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh, kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 li\u1ec1u 1 vi\u00ean\/ng\u00e0y v\u00e0 c\u1ea7n gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd.<\/li>\n
          • Ng\u01b0\u1eddi cao tu\u1ed5i: Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u theo tu\u1ed5i.<\/li>\n
          • Tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean d\u01b0\u1edbi 18 tu\u1ed5i: Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3.<\/li>\n<\/ul>\n

            C\u00e1ch s\u1eed d\u1ee5ng<\/h3>\n

            D\u00f9ng vi\u00ean u\u1ed1ng Prunitil<\/strong> theo \u0111\u01b0\u1eddng u\u1ed1ng, tr\u01b0\u1edbc ho\u1eb7c sau b\u1eefa \u0103n.<\/p>\n

            Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Prunitil trong tr\u01b0\u1eddng h\u1ee3p n\u00e0o?<\/h2>\n
              \n
            • D\u1ecb \u1ee9ng v\u1edbi Telmisartan, Hydroclorothiazid, c\u00e1c sulfonamid ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u00f3 trong Prunitil.<\/li>\n
            • Ph\u1ee5 n\u1eef mang thai \u1edf tam c\u00e1 nguy\u1ec7t th\u1ee9 hai v\u00e0 ba, c\u0169ng nh\u01b0 trong th\u1eddi k\u1ef3 cho con b\u00fa.<\/li>\n
            • B\u1ec7nh nh\u00e2n b\u1ecb t\u1eafc m\u1eadt ho\u1eb7c \u1ee9 m\u1eadt.<\/li>\n
            • Suy gan n\u1eb7ng ho\u1eb7c suy th\u1eadn n\u1eb7ng (ClCr < 30 mL\/ph\u00fat).<\/li>\n
            • R\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i nh\u01b0 h\u1ea1 kali m\u00e1u, t\u0103ng canxi m\u00e1u.<\/li>\n
            • Kh\u00f4ng ph\u1ed1i h\u1ee3p v\u1edbi Aliskiren \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ho\u1eb7c suy th\u1eadn n\u1eb7ng (GFR < 60 mL\/ph\u00fat\/1,73m\u00b2).<\/li>\n<\/ul>\n

              L\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t khi s\u1eed d\u1ee5ng thu\u1ed1c<\/h2>\n

              Th\u1eadn tr\u1ecdng<\/h3>\n
                \n
              • B\u1ec7nh nh\u00e2n suy gan kh\u00f4ng d\u00f9ng n\u1ebfu b\u1ecb \u1ee9 m\u1eadt, r\u1ed1i lo\u1ea1n \u0111\u01b0\u1eddng m\u1eadt, suy gan n\u1eb7ng; Th\u1eadn tr\u1ecdng v\u1edbi b\u1ec7nh gan \u0111ang ti\u1ebfn tri\u1ec3n (nguy c\u01a1 h\u00f4n m\u00ea gan).; Gi\u1edbi h\u1ea1n li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gan nh\u1eb9-v\u1eeba.<\/li>\n
              • T\u0103ng huy\u1ebft \u00e1p do h\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn: Nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p v\u00e0 suy th\u1eadn cao.<\/li>\n
              • Suy th\u1eadn\/gh\u00e9p th\u1eadn: Kh\u00f4ng d\u00f9ng n\u1ebfu ClCr < 30 mL\/ph\u00fat; Thi\u1ebfu d\u1eef li\u1ec7u tr\u00ean ng\u01b0\u1eddi gh\u00e9p th\u1eadn ho\u1eb7c suy th\u1eadn n\u1eb7ng; C\u1ea7n theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn, kali, acid uric.<\/li>\n
              • H\u1ea1 huy\u1ebft \u00e1p: Nguy c\u01a1 sau li\u1ec1u \u0111\u1ea7u n\u1ebfu b\u1ec7nh nh\u00e2n m\u1ea5t n\u01b0\u1edbc\/natri, ti\u00eau ch\u1ea3y, n\u00f4n.<\/li>\n
              • Phong t\u1ecfa k\u00e9p RAAS: Kh\u00f4ng n\u00ean k\u1ebft h\u1ee3p ACEi, ARB, Aliskiren \u2192 t\u0103ng nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p, t\u0103ng kali, suy th\u1eadn.<\/li>\n
              • T\u0103ng aldosterone nguy\u00ean ph\u00e1t: Kh\u00f4ng hi\u1ec7u qu\u1ea3, kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng.<\/li>\n
              • H\u1eb9p van tim, b\u1ec7nh c\u01a1 tim ph\u00ec \u0111\u1ea1i: Th\u1eadn tr\u1ecdng do nguy c\u01a1 t\u1ee5t huy\u1ebft \u00e1p.<\/li>\n
              • Chuy\u1ec3n h\u00f3a – n\u1ed9i ti\u1ebft:<\/li>\n
              • Thiazid c\u00f3 th\u1ec3 t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft, cholesterol, triglycerid, ur\u00ea m\u00e1u; g\u00e2y Gout.<\/li>\n
              • C\u00f3 th\u1ec3 k\u00edch ho\u1ea1t \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ti\u1ec1m \u1ea9n.<\/li>\n
              • M\u1ea5t c\u00e2n b\u1eb1ng \u0111i\u1ec7n gi\u1ea3i:<\/li>\n
              • Theo d\u00f5i th\u01b0\u1eddng xuy\u00ean natri, kali, magie, canxi.<\/li>\n
              • H\u1ea1 kali m\u00e1u (nh\u1ea5t l\u00e0 khi d\u00f9ng c\u00f9ng corticoid, ACTH).<\/li>\n
              • T\u0103ng kali m\u00e1u n\u1ebfu c\u00f3 suy th\u1eadn, suy tim ho\u1eb7c d\u00f9ng th\u00eam thu\u1ed1c gi\u1eef kali.<\/li>\n
              • H\u1ea1 natri, h\u1ea1 clorua m\u00e1u, ki\u1ec1m chuy\u1ec3n h\u00f3a, h\u1ea1 magie, t\u0103ng canxi c\u00f3 th\u1ec3 x\u1ea3y ra.<\/li>\n
              • Kh\u00e1c bi\u1ec7t ch\u1ee7ng t\u1ed9c: Telmisartan \u00edt hi\u1ec7u qu\u1ea3 h\u01a1n \u1edf b\u1ec7nh nh\u00e2n da \u0111en.<\/li>\n
              • T\u0103ng nh\u00e3n \u00e1p g\u00f3c \u0111\u00f3ng: Hydroclorothiazid c\u00f3 th\u1ec3 g\u00e2y c\u1eadn th\u1ecb c\u1ea5p v\u00e0 t\u0103ng nh\u00e3n \u00e1p.<\/li>\n<\/ul>\n

                T\u00e1c d\u1ee5ng ph\u1ee5<\/h3>\n
                  \n
                • Th\u01b0\u1eddn g\u1eb7p: ch\u00f3ng m\u1eb7t<\/li>\n
                • Kh\u00f4ng th\u01b0\u1eddng g\u1eb7p: lo\u1ea1n nh\u1ecbp tim, lo l\u1eafng, gi\u1ea3m kali huy\u1ebft, kh\u00f3 th\u1edf, t\u1ee5t huy\u1ebft \u00e1p, ti\u00eau ch\u1ea3y, \u0111\u1ea7y h\u01a1i, mi\u1ec7ng kh\u00f4, \u0111au l\u01b0ng, c\u01a1, ng\u1ef1c, t\u0103ng acid uric huy\u1ebft,…<\/li>\n
                • \u00cdt g\u1eb7p: Vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p (ph\u1ebf qu\u1ea3n, h\u1ecdng, xoang); suy h\u00f4 h\u1ea5p; ch\u00f3ng m\u1eb7t, m\u1ea5t ng\u1ee7, tr\u1ea7m c\u1ea3m, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan, \u0111au b\u1ee5ng, r\u1ed3i lo\u1ea1n ti\u00eau ho\u00e1, n\u00f4n, \u0111au kh\u1edbp, c\u01a1, ch\u00e2n tay,…<\/li>\n<\/ul>\n

                  T\u01b0\u01a1ng t\u00e1c<\/h3>\n