{"id":105596,"date":"2024-11-26T16:29:15","date_gmt":"2024-11-26T09:29:15","guid":{"rendered":"https:\/\/hmm88i.com\/drug\/?post_type=product&p=105596"},"modified":"2026-06-11T23:04:13","modified_gmt":"2026-06-11T16:04:13","slug":"trajenta-duo-25mg-1000mg","status":"publish","type":"product","link":"https:\/\/hmm88i.com\/drug\/trajenta-duo-25mg-1000mg\/","title":{"rendered":"Trajenta Duo 2,5mg\/1000mg"},"content":{"rendered":"

Trong b\u00e0i vi\u1ebft n\u00e0y, d\u01b0\u1ee3c s\u0129 L\u01b0u V\u0103n Ho\u00e0ng gi\u1edbi thi\u1ec7u \u0111\u1ebfn c\u00e1c b\u1ea1n s\u1ea3n ph\u1ea9m thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/a> \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Boehringer Ingelheim Pharma GmbH & Co. KG, c\u00f3 s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam l\u00e0 400110085623.<\/strong><\/p>\n

 <\/p>\n

Trajenta Duo 2,5mg\/1000mg l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n

Th\u00e0nh ph\u1ea7n<\/h3>\n

Thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/strong> c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n:<\/p>\n

    \n
  • Linagliptin 2,5mg<\/li>\n
  • Metformin hydrochloride 1000mg<\/li>\n
  • T\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/li>\n<\/ul>\n

    D\u1ea1ng b\u00e0o ch\u1ebf: Vi\u00ean n\u00e9n bao phim<\/p>\n

    Tr\u00ecnh b\u00e0y<\/h3>\n

    S\u0110K: 400110085623<\/p>\n

    Quy c\u00e1ch \u0111\u00f3ng g\u00f3i: H\u1ed9p 1 l\u1ecd x 14 vi\u00ean<\/p>\n

    Xu\u1ea5t x\u1ee9: \u0110\u1ee9c<\/p>\n

    T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Trajenta Duo 2,5mg\/1000mg<\/h2>\n

    C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\n

    Trajenta Duo 2,5mg\/1000mg ho\u1ea1t \u0111\u1ed9ng th\u00f4ng qua s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a hai th\u00e0nh ph\u1ea7n ch\u00ednh, Linagliptin v\u00e0 Metformin, \u0111\u1ec3 c\u1ea3i thi\u1ec7n ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.
    \nLinagliptin, m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf DPP-4, ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch b\u1ea3o v\u1ec7 c\u00e1c hormone incretin t\u1ef1 nhi\u00ean c\u1ee7a c\u01a1 th\u1ec3 kh\u1ecfi b\u1ecb ph\u00e2n h\u1ee7y. C\u00e1c hormone n\u00e0y, bao g\u1ed3m GLP-1 v\u00e0 GIP, \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u h\u00f2a l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u b\u1eb1ng c\u00e1ch k\u00edch th\u00edch tuy\u1ebfn t\u1ee5y ti\u1ebft insulin khi c\u1ea7n thi\u1ebft v\u00e0 \u0111\u1ed3ng th\u1eddi \u1ee9c ch\u1ebf s\u1ea3n xu\u1ea5t glucose \u1edf gan. Khi Linagliptin \u1ee9c ch\u1ebf enzyme DPP-4, c\u00e1c hormone incretin \u0111\u01b0\u1ee3c b\u1ea3o t\u1ed3n l\u00e2u h\u01a1n, t\u1eeb \u0111\u00f3 t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng c\u1ee7a ch\u00fang trong vi\u1ec7c ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n

    Trong khi \u0111\u00f3, Metformin, m\u1ed9t thu\u1ed1c thu\u1ed9c nh\u00f3m biguanid, ho\u1ea1t \u0111\u1ed9ng theo nhi\u1ec1u c\u01a1 ch\u1ebf \u0111\u1ec3 gi\u1ea3m l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u. Metformin gi\u00fap gi\u1ea3m s\u1ea3n xu\u1ea5t glucose \u1edf gan, t\u0103ng kh\u1ea3 n\u0103ng s\u1eed d\u1ee5ng glucose \u1edf c\u00e1c m\u00f4 ngo\u1ea1i bi\u00ean, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u01a1, v\u00e0 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh h\u1ea5p thu glucose \u1edf ru\u1ed9t.<\/p>\n

    \u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h3>\n\n\n\n\n\n\n\n\n\n\n
    Th\u00f4ng s\u1ed1<\/strong><\/td>\nLinagliptin<\/strong><\/td>\nMetformin<\/strong><\/td>\n<\/tr>\n
    H\u1ea5p thu<\/td>\nTmax: 1,5 gi\u1edd; Sinh kh\u1ea3 d\u1ee5ng: ~30%. Th\u1ee9c \u0103n kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3.<\/td>\nTmax: 2,5 gi\u1edd; Sinh kh\u1ea3 d\u1ee5ng: 50-60%. Th\u1ee9c \u0103n l\u00e0m gi\u1ea3m h\u1ea5p thu (~40% Cmax, ~25% AUC).<\/td>\n<\/tr>\n
    Ph\u00e2n b\u1ed1<\/td>\nTh\u1ec3 t\u00edch ph\u00e2n b\u1ed1: ~1110L. Li\u00ean k\u1ebft protein ph\u1ee5 thu\u1ed9c n\u1ed3ng \u0111\u1ed9 (99% \u1edf 1nmol\/L, gi\u1ea3m khi n\u1ed3ng \u0111\u1ed9 >30nmol\/L).<\/td>\nTh\u1ec3 t\u00edch ph\u00e2n b\u1ed1: 63-276L. G\u1eafn kh\u00f4ng \u0111\u00e1ng k\u1ec3 v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng; ph\u00e2n b\u1ed1 v\u00e0o h\u1ed3ng c\u1ea7u.<\/td>\n<\/tr>\n
    Chuy\u1ec3n h\u00f3a<\/td>\nChuy\u1ec3n h\u00f3a \u00edt; ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd.<\/td>\nKh\u00f4ng chuy\u1ec3n h\u00f3a. \u0110\u01b0\u1ee3c th\u1ea3i tr\u1eeb d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i qua n\u01b0\u1edbc ti\u1ec3u.<\/td>\n<\/tr>\n
    Th\u1ea3i tr\u1eeb<\/td>\nTh\u1eddi gian b\u00e1n th\u1ea3i: >100 gi\u1edd (pha cu\u1ed1i). Ch\u1ee7 y\u1ebfu qua ph\u00e2n (80%), n\u01b0\u1edbc ti\u1ec3u (5%).<\/td>\nTh\u1eddi gian b\u00e1n th\u1ea3i bi\u1ec3u ki\u1ebfn: ~6,5 gi\u1edd. Th\u1ea3i tr\u1eeb qua th\u1eadn (l\u1ecdc c\u1ea7u th\u1eadn v\u00e0 b\u00e0i ti\u1ebft \u1ed1ng th\u1eadn).<\/td>\n<\/tr>\n
    Suy th\u1eadn<\/td>\nKh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u \u1edf m\u1ecdi m\u1ee9c \u0111\u1ed9 suy th\u1eadn. N\u1ed3ng \u0111\u1ed9 t\u0103ng nh\u1eb9 \u1edf suy th\u1eadn trung b\u00ecnh (~1,7 l\u1ea7n) v\u00e0 n\u1eb7ng (~1,4 l\u1ea7n).<\/td>\nKhi suy th\u1eadn, thanh th\u1ea3i gi\u1ea3m t\u1ef7 l\u1ec7 v\u1edbi \u0111\u1ed9 thanh th\u1ea3i creatinine, d\u1eabn \u0111\u1ebfn t\u0103ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng.<\/td>\n<\/tr>\n
    Suy gan<\/td>\nKh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u. AUC v\u00e0 Cmax t\u01b0\u01a1ng t\u1ef1 \u1edf m\u1ecdi m\u1ee9c \u0111\u1ed9 suy gan (Child-Pugh nh\u1eb9, trung b\u00ecnh, n\u1eb7ng).<\/td>\nKh\u00f4ng c\u00f3 d\u1eef li\u1ec7u.<\/td>\n<\/tr>\n
    Tr\u1ebb em<\/td>\nCh\u01b0a c\u00f3 nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7.<\/td>\nN\u1ed3ng \u0111\u1ed9 Cmax v\u00e0 AUC gi\u1ea3m \u1edf tr\u1ebb em (~33% v\u00e0 ~40% so v\u1edbi ng\u01b0\u1eddi l\u1edbn); \u00edt \u00fd ngh\u0129a l\u00e2m s\u00e0ng do li\u1ec1u \u0111i\u1ec1u ch\u1ec9nh theo \u0111\u01b0\u1eddng huy\u1ebft.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Thu\u1ed1c Trajenta Duo 2,5mg\/1000mg \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong b\u1ec7nh g\u00ec?<\/h2>\n

    Trajenta Duo 2,5mg\/1000mg<\/strong> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh nh\u01b0 m\u1ed9t l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb b\u1ed5 sung cho b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng type 2 (khi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng m\u00e1u) cho c\u00e1c tr\u01b0\u1eddng h\u1ee3p sau:<\/p>\n